CEP43 - centrosomal protein 43 Gene

Homo sapiens

Also known as FOP; FGFR1OP

Gene ID: 11116 | Gene type: protein coding

About CEP43

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:166,999,397-167,052,718 (from NCBI)

This gene has 41 transcripts (splice variants), 197 orthologues and is associated with 51 phenotypes. Broad expression in testis (RPKM 19.6), adrenal (RPKM 5.3) and 24 other tissues.

Summary

This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the Fibroblast Growth Factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

CEP43 Products(3)

mRNA	Protein	Name
NM_001278690.2	NP_001265619.1	centrosomal protein 43 isoform c
NM_007045.4	NP_008976.1	centrosomal protein 43 isoform a
NM_194429.3	NP_919410.1	centrosomal protein 43 isoform b

CEP43 Protein Structure

FOP_dimer

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

centrosomal protein 43

FGFR1 oncogene partner

Recombinant CEP43 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76927	FGFR1OP Protein, Human (sf9, His-GST)	O95684-2 (A2-A379)	≥95%

Related Diseases

Diseases

Alias

Graves' Disease

Graves Disease	Exophthalmic Goiter
Basedow'S Disease	Grave'S Disease
Basedow Disease	Toxic Diffuse Goiter
Graves' Hyperthyroidism	Parry Disease
Autoimmune Hyperthyroidism	Toxic Multinodular Goiter

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02515	CEP43 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CEP43	MGD	MGI:1922546
Felis catus	CEP43	VGNC	VGNC:62259
Bos taurus	CEP43	VGNC	VGNC:28985
Canis familiaris	CEP43	VGNC	VGNC:40857
Rattus norvegicus	CEP43	RGD	RGD:1583370
Macaca mulatta	CEP43	VGNC	VGNC:72519
Others	CEP43	NCBI

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