ACOT12 - acyl-CoA thioesterase 12 Gene

Homo sapiens

Also known as Cach; THEAL; CACH-1; STARD15

Gene ID: 134526 | Gene type: protein coding

About ACOT12

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:81,308,609-81,394,134 (from NCBI)

This gene has 4 transcripts (splice variants), 143 orthologues and 2 paralogues. Biased expression in liver (RPKM 11.8) and kidney (RPKM 0.6).

Summary

Enables identical protein binding activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to act upstream of or within acetyl-CoA metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ACOT12 Products(1)

mRNA	Protein	Name
NM_130767.3	NP_570123.1	acetyl-coenzyme A thioesterase

ACOT12 Protein Structure

4HBT

START

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

acetyl-coenzyme A thioesterase

START domain-containing protein 15

Related Diseases

Diseases

Alias

Thyroid Dyshormonogenesis 5

TDH5	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5
Thyroid Hormonogenesis, Genetic Defect In, 5	Genetic Defect In Thyroid Hormonogenesis 5
Chdh5	Congenital Hypothyroidism Due To Dyshormonogenesis Type 5
Genetic Defect In Thyroid Hormonogenesis Type 5

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00175	ACOT12 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ACOT12	MGD	MGI:1921406
Rattus norvegicus	ACOT12	RGD	RGD:619752
Canis familiaris	ACOT12	VGNC	VGNC:37517
Felis catus	ACOT12	VGNC	VGNC:59519
Macaca mulatta	ACOT12	VGNC	VGNC:69530
Bos taurus	ACOT12	VGNC	VGNC:25548

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