ACOT12 - acyl-CoA thioesterase 12 Gene

Also Known as Cach; THEAL; CACH-1; STARD15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 134526

About ACOT12

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:81,308,609-81,394,134 (from NCBI)

This gene has 4 transcripts (splice variants), 143 orthologues and 2 paralogues. Biased expression in liver (RPKM 11.8) and kidney (RPKM 0.6).

Summary

Enables identical protein binding activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to act upstream of or within acetyl-CoA metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ACOT12 Products (1)

mRNA Protein Name
NM_130767.3 NP_570123.1 acetyl-coenzyme A thioesterase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT12 Protein Structure

4HBT

4HBT: Thioesterase superfamily (27 - 96)

4HBT

4HBT: Thioesterase superfamily (197 - 271)

START

START: START domain (359 - 512)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
Protein Preferred Names Protein Names

acetyl-coenzyme A thioesterase

  • START domain-containing protein 15

ACOT12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACOT12 Q8WYK0 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 ZBTB8A Homo sapiens Q96BR9
Validated Y2H
32296183
Intra
ACOT12 Q8WYK0 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 ACOT12 Homo sapiens Q8WYK0
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 ZBTB8A Homo sapiens Q96BR9
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 NAA11 Homo sapiens Q9BSU3
Validated Y2H
32296183
Intra
ACOT12 Q8WYK0 ACOT12 Homo sapiens Q8WYK0
Validated Y2H
32296183
Intra
ACOT12 Q8WYK0 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 ZBTB8A Homo sapiens Q96BR9
Anti Tag CoIP
33961781
Intra
ACOT12 Q8WYK0 ACOT12 Homo sapiens Q8WYK0
Y2H Array
32296183
Intra
ACOT12 Q8WYK0 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
ACOT12 Q8WYK0 ZBTB8A Homo sapiens Q96BR9
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thyroid Dyshormonogenesis 5

  • TDH5

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5

  • Thyroid Hormonogenesis, Genetic Defect In, 5

  • Genetic Defect In Thyroid Hormonogenesis 5

  • Chdh5

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 5

  • Genetic Defect In Thyroid Hormonogenesis Type 5
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00175 ACOT12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACOT12 MGD MGI:1921406
Rattus norvegicus ACOT12 RGD RGD:619752
Canis familiaris ACOT12 VGNC VGNC:37517
Felis catus ACOT12 VGNC VGNC:59519
Macaca mulatta ACOT12 VGNC VGNC:69530
Bos taurus ACOT12 VGNC VGNC:25548
Others ACOT12 NCBI