CPM - carboxypeptidase M Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1368

About CPM

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,842,197-68,963,469 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in fat (RPKM 56.0), lung (RPKM 21.3) and 19 other tissues.

Summary

The protein encoded by this gene is a membrane-bound arginine/lysine Carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

CPM Products (21)

mRNA Protein Name
NM_001005502.3 NP_001005502.1 carboxypeptidase M isoform b precursor
NM_001413387.1 NP_001400316.1 carboxypeptidase M isoform a precursor
NM_001413388.1 NP_001400317.1 carboxypeptidase M isoform b precursor
NM_001413389.1 NP_001400318.1 carboxypeptidase M isoform b precursor
NM_001413390.1 NP_001400319.1 carboxypeptidase M isoform b precursor
NM_001413391.1 NP_001400320.1 carboxypeptidase M isoform b precursor
NM_001413392.1 NP_001400321.1 carboxypeptidase M isoform c
NM_001413393.1 NP_001400322.1 carboxypeptidase M isoform d precursor
NM_001413394.1 NP_001400323.1 carboxypeptidase M isoform d precursor
NM_001413395.1 NP_001400324.1 carboxypeptidase M isoform e
NM_001413396.1 NP_001400325.1 carboxypeptidase M isoform e
NM_001413397.1 NP_001400326.1 carboxypeptidase M isoform f
NM_001413398.1 NP_001400327.1 carboxypeptidase M isoform f
NM_001413399.1 NP_001400328.1 carboxypeptidase M isoform f
NM_001413400.1 NP_001400329.1 carboxypeptidase M isoform f
NM_001413401.1 NP_001400330.1 carboxypeptidase M isoform f
NM_001413402.1 NP_001400331.1 carboxypeptidase M isoform g precursor
NM_001413403.1 NP_001400332.1 carboxypeptidase M isoform h
NM_001413404.1 NP_001400333.1 carboxypeptidase M isoform h
NM_001874.5 NP_001865.1 carboxypeptidase M isoform b precursor
NM_198320.5 NP_938079.1 carboxypeptidase M isoform b precursor

CPM Protein Structure

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (28 - 302)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (315 - 381)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 443 a.a.
Protein Preferred Names Protein Names

carboxypeptidase M

  • renal carboxypeptidase

Recombinant CPM Proteins

Cat. No. Product Name Accession Purity
HY-P7737 Carboxypeptidase M/CPM Protein, Human (HEK293, His) P14384 (L18-D421) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lateral Medullary Syndrome

  • Posterior Inferior Cerebellar Artery Syndrome

  • Wallenberg Syndrome

  • Vertebral Artery Syndrome

  • Wallenberg'S Syndrome

  • Pica Syndrome
Esophagus Sarcoma

  • Esophageal Sarcoma
Breast Liposarcoma

  • Liposarcoma Of The Breast
Liposarcoma

  • Lipomatous Cancer
Pneumoconiosis

  • Pneumoconioses

  • Silicosis Nos

  • Complicated Silicosis

  • Fibrosis Of Lung With Silicosis

  • Nodular Silicosis

  • Pneumoconiosis Due To Silica

  • Silicotic Fibrosis Of Lung

  • Simple Silicosis

  • Silicatosis

  • Silicotic Lung Fibrosis

  • Pneumoconiosis Due To Talc

  • Pulmonary Talcosis

  • Talc Lung Disease

  • Talc Pneumoconiosis

  • Talc Workers' Pneumoconiosis

  • Talcosis

  • Fibrosis Of Lung Due To Talc

  • Asbestos Pneumoconiosis

  • Amianthosis

  • Asbestosis

  • Lung Fibrosis With Asbestosis

  • Pulmonary Asbestosis
Brain Stem Infarction

  • Brain Stem Infarctions

  • Brainstem Infarction
Well-Differentiated Liposarcoma

  • Atypical Lipomatous Tumor

  • Atypical Lipoma

  • Alt

  • Wdls

  • Liposarcoma, Well Differentiated

  • Pleomorphic Lipoma
Hereditary Angioedema

  • Hereditary Angioneurotic Edema

  • Hereditary Angioedema Type 1

  • Hane

  • Angioedema, Hereditary

  • Hae

  • Angioedemas, Hereditary

  • Deficiency Of C1 Esterase Inhibitor

  • C1 Esterase Inhibitor Deficiency

  • C1 Inhibitor Deficiency

  • Familial Angioneurotic Edema

  • Hereditary Bradykinine-Induced Angioedema

  • Hereditary Non Histamine-Induced Angioedema

  • Hae 1

  • Hae-I

  • Hereditary Angioneurotic Edema Type 1

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii

  • Hereditary Angioneurotic Oedema

  • Familial Angioedema

  • Hae - [Hereditary Angioneurotic Oedema]

  • Bannister Disease, Hereditary

  • Quincke Disease Or Oedema

  • Hereditary Quincke Oedema
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13010 Laquinimod 99.46% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-D0069 CPM ≥99.0% Phase 4
HY-W062904 Laquinimod sodium Inhibitor / Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03100 CPM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13010S Laquinimod-d5 Inhibitor 98.25% Unkown
HY-P10057 cpm-1285 Inducer / Unkown
HY-P10058 cpm-1285m / Unkown
HY-D2376 BH-Vis / Unkown
HY-RS17394 Cpm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23849 Cpm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPM VGNC VGNC:54521
Bos taurus CPM VGNC VGNC:27655
Mus musculus CPM MGD MGI:1917824
Rattus norvegicus CPM RGD RGD:1310532
Macaca mulatta CPM VGNC VGNC:71461
Felis catus CPM VGNC VGNC:61126
Others CPM NCBI