2. Gene
  3. CREBL2 - cAMP responsive element binding protein like 2 Gene

CREBL2 - cAMP responsive element binding protein like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 1389 | Gene type: protein coding

About CREBL2

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,611,876-12,645,108 (from NCBI)

This gene has 2 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in adrenal (RPKM 84.6), thyroid (RPKM 31.5) and 23 other tissues.

Summary

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 Amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

CREBL2 Products(1)

mRNA Protein Name
NM_001310.4 NP_001301.1 cAMP-responsive element-binding protein-like 2

CREBL2 Protein Structure

bZIP_2

bZIP_2: Basic region leucine zipper (28 - 75)

  • 0
  • 100
  • 120 a.a.
Protein Preferred Names Protein Names

cAMP-responsive element-binding protein-like 2

MHBs-binding protein 1

Related Diseases

Diseases Alias
Temtamy Syndrome

TEMTYS

Craniofacial Dysmorphism With Ocular Coloboma Absent Corpus Callosum And Aortic Dilatation

Craniofacial Dysmorphism-Coloboma-Corpus Callosum Agenesis Syndrome

Dysmorphism, Corpus Callosum Agenesis And Colobomas

Temtamy-Shalash Syndrome

Mental Retardation With Or Without Craniofacial Dysmorphism, Ocular Coloboma, Or Abnormal Corpus Callosum
Cantu Syndrome

Hypertrichotic Osteochondrodysplasia

Hypertrichotic Osteochondrodysplasia Cantu Type

Cantú Syndrome

Craniofaciocardioskeletal Syndrome

Hypertrichosis-Osteochondrodysplasia-Cardiomegaly Syndrome

Congenital Hypertrichosis-Acromegaloid Facial Features Spectrum

Congenital Hypertrichosis-Coarse Facial Features Spectrum

HTOCD

Osteochondrodysplasia, Hypertrichotic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03158 CREBL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CREBL2 VGNC VGNC:71488
Rattus norvegicus CREBL2 RGD RGD:1309502
Mus musculus CREBL2 MGD MGI:1889385
Felis catus CREBL2 VGNC VGNC:61172
Canis familiaris CREBL2 VGNC VGNC:39602
Bos taurus CREBL2 VGNC VGNC:27699