DPYSL3 - dihydropyrimidinase like 3 Gene

Also Known as DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1809

About DPYSL3

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:147,390,808-147,510,068 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 5 paralogues. Broad expression in brain (RPKM 51.8), prostate (RPKM 49.3) and 22 other tissues.

Summary

Enables filamin binding activity. Predicted to be involved in several processes, including actin filament organization; regulation of plasma membrane bounded cell projection organization; and response to axon injury. Predicted to act upstream of or within nervous system development. Predicted to be located in several cellular components, including cell body; growth cone; and lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in synapse. Predicted to colocalize with exocytic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

DPYSL3 Products (2)

mRNA Protein Name
NM_001197294.2 NP_001184223.1 dihydropyrimidinase-related protein 3 isoform 1
NM_001387.3 NP_001378.1 dihydropyrimidinase-related protein 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables filamin binding IPI
IPI: Inferred from physical interaction
25358863 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPYSL3 Protein Structure

Amidohydro_1

Amidohydro_1: Amidohydrolase family (64 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 570 a.a.
Protein Preferred Names Protein Names

dihydropyrimidinase-related protein 3

  • collapsin response mediator protein 4 long

DPYSL3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPYSL3 Q14195 DPYSL2 Homo sapiens Q16555
Anti Tag CoIP
28514442
Intra
DPYSL3 Q14195 DPYSL2 Homo sapiens Q16555
Anti Tag CoIP
33961781
Intra
DPYSL3 Q14195 DPYSL2 Homo sapiens Q16555
Y2H Array
29892012
Intra
DPYSL3 Q14195 DPYSL2 Homo sapiens Q16555
Y2H Array
31515488
Intra
DPYSL3 Q14195 ACD Homo sapiens Q96AP0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPYSL3 Proteins

Cat. No. Product Name Accession Purity
HY-P71546 DPYSL3 Protein, Human (His) Q14195 (M1-S570) ≥ 90%, as determined by reducing SDS-PAGE.

DPYSL3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83032 CRMP4 Antibody (YA2777) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03982 DPYSL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20151 Dpysl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26655 Dpysl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DPYSL3 VGNC VGNC:28196
Rattus norvegicus DPYSL3 RGD RGD:2410
Canis familiaris DPYSL3 VGNC VGNC:40084
Felis catus DPYSL3 VGNC VGNC:61616
Macaca mulatta DPYSL3 VGNC VGNC:71985
Mus musculus DPYSL3 MGD MGI:1349762
Others DPYSL3 NCBI