EIF5 - eukaryotic translation initiation factor 5 Gene

Also Known as EIF-5; EIF-5A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1983

About EIF5

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:103,334,237-103,345,025 (from NCBI)

This gene has 21 transcripts (splice variants) and 265 orthologues. Ubiquitous expression in bone marrow (RPKM 60.5), thyroid (RPKM 44.5) and 25 other tissues.

Summary

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010]

EIF5 Products (2)

mRNA Protein Name
NM_001969.5 NP_001960.2 eukaryotic translation initiation factor 5
NM_183004.5 NP_892116.2 eukaryotic translation initiation factor 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21745818 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of translational initiation IDA
IDA: Inferred from direct assay
22156057 GOA
involved in ribosome assembly IDA
IDA: Inferred from direct assay
10659855 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF5 Protein Structure

eIF-5_eIF-2B

eIF-5_eIF-2B: Domain found in IF2B/IF5 (3 - 128)

W2

W2: eIF4-gamma/eIF5/eIF2-epsilon (308 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 5

EIF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Y2H Array
32296183
Intra
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
25416956
Intra
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Validated Y2H
32296183
Intra
EIF5 P55010 DUSP12 Homo sapiens Q9UNI6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF5 Proteins

Cat. No. Product Name Accession Purity
HY-P75255 EIF5 Protein, Human (His) P55010 (M1-D150) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700566 EIF5 Protein, Human (His-SUMO) P55010 (M1-I431) ≥ 90%, as determined by reducing SDS-PAGE.

EIF5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84399 EIF5 Antibody (YA4096) IHC-P, ICC/IF, FC, ELISA Human
HY-P84399A EIF5 Antibody (YA4096)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Leukoencephalopathy With Vanishing White Matter

  • Cree Leukoencephalopathy

  • Vanishing White Matter Disease

  • Ovarioleukodystrophy

  • Vanishing White Matter Leukodystrophy

  • Childhood Ataxia With Central Nervous System Hypomyelinization

  • Cach

  • Cach Syndrome

  • Myelinosis Centralis Diffusa

  • VWM

  • Cle

  • Childhood Ataxia With Central Nervous System Hypomyelination

  • Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

  • Cach/Vwm

  • Cach/Vwm Syndrome

  • Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

  • Cree Leukoencehalopathy

  • Late Infantile Cach Syndrome

  • Juvenile Or Adult Cach Syndrome

  • Congenital Or Early Infantile Cach Syndrome

  • Leukodystrophy With Vanishing White Matter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2397 9''-Methyl salvianolate B 99.54% Unkown
HY-111522 RK-9123016 Inhibitor 99.65% Unkown
HY-106801 Girolline / Unkown
HY-RS04286 EIF5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121722 Deoxyhypusine / Unkown
HY-122039 Hypusine dihydrochloride / Unkown
HY-RS04285 EIF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04287 EIF5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04288 EIF5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18929 Eif5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19060 Eif5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19678 Eif5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22482 Eif5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25419 Eif5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25550 Eif5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26171 Eif5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29005 Eif5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EIF5 VGNC VGNC:28418
Felis catus EIF5 VGNC VGNC:61797
Rattus norvegicus EIF5 RGD RGD:619861
Macaca mulatta EIF5 VGNC VGNC:72197
Canis familiaris EIF5 VGNC VGNC:40292
Mus musculus EIF5 MGD MGI:95309
Others EIF5 NCBI