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FKBP4 - FKBP prolyl isomerase 4 Gene

Also Known as HBI; p52; Hsp56; FKBP51; FKBP52; FKBP59; PPIase

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2288

About FKBP4

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,794,970-2,805,423 (from NCBI)

This gene has 8 transcripts (splice variants), 218 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 21.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (HSP90 and HSP70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

FKBP4 Products (1)

mRNA	Protein	Name
NM_002014.4	NP_002005.1	peptidyl-prolyl cis-trans isomerase FKBP4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	11350175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11583998	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	11350175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP4 Protein Structure

FKBP_C

TPR_1

TPR_11

0
100
200
300
400
459 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase FKBP4	FK506 binding protein 4, 59kDa

FKBP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FKBP4	Q02790	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	25036637
Intra	FKBP4	Q02790	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	FKBP4	Q02790	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	FKBP4	Q02790	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	20188096
Intra	FKBP4	Q02790	HSP90AA1	Homo sapiens	P07900	Pull Down	20188096
Intra	FKBP4	Q02790	HSP90AB1	Homo sapiens	P08238	Solution Sedimentation	21170051
Intra	FKBP4	Q02790	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	FKBP4	Q02790	HSP90AB1	Homo sapiens	P08238	Anti Bait CoIP	21730179
Intra	FKBP4	Q02790	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	FKBP4	Q02790	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
Intra	FKBP4	Q02790	HSPB1	Homo sapiens	P04792	Anti Bait CoIP	25277244
Intra	FKBP4	Q02790	S100A6	Homo sapiens	P06703	Anti Tag CoIP	20188096
Intra	FKBP4	Q02790	S100A6	Homo sapiens	P06703	Pull Down	20188096
Intra	FKBP4	Q02790	S100A6	Homo sapiens	P06703	Competition Binding	20188096
Intra	FKBP4	Q02790	MAPT	Homo sapiens	P10636-8	Far-WB	20133804
Intra	FKBP4	Q02790	AR	Homo sapiens	P10275	Anti Bait CoIP	21730179
Intra	FKBP4	Q02790	GLMN	Homo sapiens	Q92990	Anti Tag CoIP	25036637
Intra	FKBP4	Q02790	GLMN	Homo sapiens	Q92990	Validated Y2H	32296183
Intra	FKBP4	Q02790	S100A2	Homo sapiens	P29034	Pull Down	20188096
Intra	FKBP4	Q02790	S100A2	Homo sapiens	P29034	Anti Tag CoIP	20188096
Intra	FKBP4	Q02790	S100A2	Homo sapiens	P29034	Competition Binding	20188096
Cross	FKBP4	Q02790	S100a1	Rattus norvegicus	P35467	Pull Down	14638689
Cross	FKBP4	Q02790	S100a1	Rattus norvegicus	P35467	Competition Binding	20188096
Cross	FKBP4	Q02790	S100a1	Rattus norvegicus	P35467	Anti Tag CoIP	20188096
Cross	FKBP4	Q02790	S100a1	Rattus norvegicus	P35467	Pull Down	20188096

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FKBP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70405	FKBP4 Protein, Human (His)	Q02790 (M1-A459)	≥ 95%, as determined by reducing SDS-PAGE.

FKBP4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80402	FKBP52 Antibody (YA432)	WB, ICC/IF, IHC-P, FC	Human, Mouse

Related Diseases

Diseases	Alias
Androgen Insensitivity Syndrome	Androgen Resistance Syndrome AIS Testicular Feminization Syndrome Androgen Receptor Deficiency Dhtr Deficiency Dihydrotestosterone Receptor Deficiency Ar Deficiency Testicular Feminization Tfm Androgen Insensitivity Androgen-Insensitivity Syndrome Goldberg-Maxwell Syndrome Complete Androgen Insensitivity Syndrome Cais Feminisation - Testicular Goldberg - Maxwell Syndrome Androgen Insensitivity Syndrome, Complete Morris Syndrome Ary AR Insensitivity Syndrome, Androgen Androgen Insensitivity Nos
Paralytic Lagophthalmos
Ocular Hypertension	Hypertension, Ocular Intraocular Pressure Increase Oh - [Ocular Hypertension] Oht - [Ocular Hypertension]
Sulfhemoglobinemia
Hypospadias	Hypospadias Familial Familial Hypospadias
Facial Paralysis	Facial Palsy Bell Palsy
Facial Nerve Disease	Facial Nerve Disorder Facial Nerve Diseases Neuropathy Of Facial Nerve Disorders Of 7th Cranial Nerve Disorders Of The Seventh Cranial Nerve
Bell'S Palsy	Bell Palsy Facial Nerve Palsy Facial Palsy Facial Paralysis Bell'S Palsy Antoni'S Palsy Facial Cranial Nerve Paralysis Idiopathic Facial Palsy Refrigeration Palsy Facial Nerve Paralysis Seventh Cranial Nerve Paralysis Face Paralysis Nos
Non-Suppurative Otitis Media	Nonsuppurative Otitis Media
Cerebellopontine Angle Tumor	Cerebellopontine Angle Tumour Neoplasm Of The Cerebellopontine Angle
Schwannoma Of Twelfth Cranial Nerve	Hypoglossal Schwannoma Schwannoma Of The Twelfth Cranial Nerve
Hypoglossal Nerve Disease	Hypoglossal Nerve Diseases Disorder Of 12th Nerve Disorder Of Hypoglossal [12th] Nerve Disorder Of Hypoglossal Nerve Disorder Of Xii Nerve Disorders Of The Twelfth Cranial Nerve Disorders Of 12th Cranial Nerve
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Skin Atrophy	Atrophic Condition Of Skin Atrophoderma Atrophy - Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04964	FKBP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18819	Fkbp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25309	Fkbp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FKBP4	RGD	RGD:628729
Mus musculus	FKBP4	MGD	MGI:95543
Macaca mulatta	FKBP4	VGNC	VGNC:72664
Felis catus	FKBP4	VGNC	VGNC:62280
Bos taurus	FKBP4	VGNC	VGNC:29023
Canis familiaris	FKBP4	VGNC	VGNC:40890
Others	FKBP4	NCBI