FKBP4 Protein, Human (His)
The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag.
FKBP4 Protein, an immunophilin, exhibits both peptidyl-prolyl cis-trans isomerase (PPIase) and co-chaperone activities. It functions as a crucial component within heterocomplexes formed with steroid receptors, interacting notably with heat-shock protein 90 (HSP90). This interaction suggests a potential role in facilitating the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between the cytoplasm and nuclear compartments. Furthermore, FKBP4's isomerase activity influences neuronal growth cones by modulating the opening of TRPC1 channels and serves as a regulator of microtubule dynamics by inhibiting MAPT/TAU's ability to promote microtubule assembly. Additionally, FKBP4 may contribute to mitochondrial protection against oxidative stress.
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
Q02790 (M1-A459)
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Molecular Construction
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N-term
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FKBP4 (M1-A459)
Accession # Q02790 -
6*His
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C-term
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Protein Length
Full Length
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Synonyms
FKBP4; HSP Binding Immunophilin; FKBP Prolyl Isomerase 4; HSP-Binding Immunophilin; FKBP59; Peptidylprolyl Isomerase; FKBP52; FK506 Binding Protein 4; Rotamase; FK506-Binding Protein 4; Peptidyl-Prolyl Cis-Trans Isomerase FKBP4; Immunophilin FKBP52; FK506
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AA Sequence
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
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Predicted Molecular Mass
52.8 kDa
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Molecular Weight
Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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