Grk1 - G protein-coupled receptor kinase 1 Gene

Also Known as Rk; Rhok; Gprk1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24013

Summary

Predicted to enable rhodopsin kinase activity. Acts upstream of or within several processes, including photoreceptor cell morphogenesis; positive regulation of phosphorylation; and post-embryonic retina morphogenesis in camera-type eye. Located in photoreceptor outer segment. Is expressed in retina outer nuclear layer. Used to study Oguchi disease-2. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Grk1 Products (1)

mRNA Protein Name
NM_011881.3 NP_036011.3 rhodopsin kinase GRK1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of phosphorylation IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of or within photoreceptor cell morphogenesis IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of or within positive regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of or within post-embryonic retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of or within response to light stimulus IMP
IMP: Inferred from mutant phenotype
10097103 MGI
acts upstream of retinal rod cell apoptotic process IMP
IMP: Inferred from mutant phenotype
10097103 MGI
Cellular Component GO Annotation Evidence References Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
22183407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rhodopsin kinase GRK1

  • G-protein receptor kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103045 CMPD101 Inhibitor 98.96% Unkown
HY-142812 GRK6-IN-1 99.61% Unkown
HY-18991 CCG215022 Inhibitor 99.79% Unkown
HY-109562A CCG258208 hydrochloride 98.05% Unkown
HY-139690 CCG258747 98.96% Unkown
HY-109562 CCG258208 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-119232 GSK466317A Inhibitor / Unkown
HY-120168 CCG 258001 Inhibitor / Unkown
HY-RS05812 GRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk1 NCBI NCBI:6011