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GRK2-IN-1 

Cat. No.: HY-109562
Handling Instructions

GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM). GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine.

For research use only. We do not sell to patients.

GRK2-IN-1 Chemical Structure

GRK2-IN-1 Chemical Structure

CAS No. : 2055990-90-2

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Description

GRKs-IN-1, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=30 nM) and GRK5 (IC50=7.1 μM). GRKs-IN-1 is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].

IC50 & Target

GRK2

30 nM (IC50)

GRK5

7.1 μM (IC50)

Molecular Weight

452.48

Formula

C₂₄H₂₅FN₄O₄

CAS No.

2055990-90-2

SMILES

FC1=C(C(NCC2=NNC=C2)=O)C=C([[email protected]]3[[email protected]](COC4=CC=C(OCO5)C5=C4)CNCC3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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GRK2-IN-1
Cat. No.:
HY-109562
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