GRK1 - G protein-coupled receptor kinase 1 Gene

Also Known as RK; RHOK; GPRK1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6011

About GRK1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,648,199-113,737,736 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 228 orthologues, 7 paralogues and is associated with 4 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

GRK1 Products (1)

mRNA Protein Name
NM_002929.3 NP_002920.1 rhodopsin kinase GRK1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables rhodopsin kinase activity IDA
IDA: Inferred from direct assay
15946941 GOA
Biological Process GO Annotation Evidence References Source
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
15946941 GOA
involved in regulation of opsin-mediated signaling pathway IDA
IDA: Inferred from direct assay
15946941 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK1 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (58 - 174)

Pkinase

Pkinase: Protein kinase domain (194 - 443)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
Protein Preferred Names Protein Names

rhodopsin kinase GRK1

GRK1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811266 GRK1 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Oguchi Disease 2

  • Oguchi Disease-2

  • CSNBO2

  • Night Blindness, Congenital Stationary, Oguchi Type 2

  • Congenital Stationary Night Blindness Oguchi Type 2
Oguchi Disease

  • Stationary Night Blindness, Oguchi Type

  • Congenital Stationary Night Blindness, Oguchi Type

  • Oguchi Syndrome

  • Oguchis Disease
Congenital Stationary Night Blindness

  • Night Blindness, Congenital Stationary

  • Congenital Essential Nyctalopia

  • Oguchi Disease

  • Blindness, Night, Stationary, Congenital
Night Blindness

  • Nyctalopia
Enhanced S-Cone Syndrome

  • Goldmann-Favre Syndrome

  • ESCS

  • Favre Hyaloideoretinal Degeneration

  • Retinoschisis With Early Hemeralopia

  • Retinoschisis With Early Nyctalopia

  • Enhanced S Cone Syndrome

  • S-Cone Syndrome, Enhanced
Oguchi Disease 1

  • Oguchi Disease-1

  • CSNBO1

  • Night Blindness, Congenital Stationary, Oguchi Type 1

  • Congenital Stationary Night Blindness Oguchi Type 1

  • Oguchi Disease
Prothrombin Thrombophilia

  • Prothrombin G20210a Thrombophilia

  • Hyperprothrombinemia
Retinoschisis 1, X-Linked, Juvenile

  • Retinoschisis

  • X-Linked Retinoschisis

  • X-Linked Juvenile Retinoschisis

  • RS1

  • XLRS1

  • X-Linked Juvenile Retinoschisis 1

  • Xlrs

  • Retinoschisis, X-Linked

  • Rs

  • Congenital X-Linked Retinoschisis

  • Degenerative Retinoschisis

  • Juvenile Retinoschisis

  • Xjr

  • Retinoschisis Juvenile X-Linked 1

  • Retinoschisis, Juvenile, X-Linked

  • Retinoschisis, Degenerative
Leber Congenital Amaurosis 1

  • LCA1

  • Amaurosis Congenita Of Leber I

  • Lca

  • Retinal Blindness, Congenital

  • Crb

  • Leber Congenital Amaurosis Type I

  • Leber Congenital Amaurosis, Type 1

  • Amaurosis Congenita Of Leber, Type 1
Prolonged Electroretinal Response Suppression

  • Bradyopsia

  • PERRS
Abnormal Threshold Of Rods

  • Abnormal Dark Adaptation Curve
Myasthenic Syndrome, Congenital, 3a, Slow-Channel

  • Congenital Myasthenic Syndrome 3a

  • CMS3A

  • Congenital Myasthenic Syndrome 3a, Slow-Channel

  • Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Retinal Degeneration

  • Degeneration Of Retina
Retinitis Pigmentosa 45

  • RP45

  • Retinitis Pigmentosa, Type 45
Leber Congenital Amaurosis 12

  • LCA12

  • Leber Congenital Amaurosis, Type 12
Retinitis Pigmentosa 2

  • RP2

  • X-Linked Retinitis Pigmentosa 2

  • Xlrp2

  • Xlrp-2

  • Retinitis Pigmentosa-2

  • Retinitis Pigmentosa, Type 2
Fundus Albipunctatus

  • Retinitis Punctata Albescens

  • Pigmentary Retinal Dystrophy

  • RPA

  • Albipunctate Retinal Dystrophy

  • Lauber'S Disease

  • FALBI

  • Fa
Leber Congenital Amaurosis 10

  • LCA10

  • Leber Congenital Amaurosis, Type 10
Retinitis Pigmentosa 3

  • RP3

  • Retinitis Pigmentosa 15

  • Rp15

  • Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women

  • Cone-Rod Degeneration, X-Linked

  • Retinitis Pigmentosa Type 15

  • X-Linked Cone-Rod Degeneration

  • X-Linked Retinitis Pigmentosa 3

  • Xlrp3

  • Xlrp-3

  • Retinitis Pigmentosa-3

  • Retinitis Pigmentosa, Type 3
Achromatopsia

  • Achm

  • Rod Monochromatism

  • Total Color Blindness

  • Rod Monochromacy

  • Monochromatism

  • Achromatism

  • Complete Or Incomplete Color Blindness

  • Pingelapese Blindness

  • Achromatopsia 1

  • Achromatopsia 2

  • Achromatopsia 3
Color Blindness

  • Color Vision Defect

  • Blindness Color

  • Colour Blindness

  • Colour Vision Deficiency

  • Color Vision Deficiency

  • Color Vision Defects

  • Defective Color Vision

  • Vision Defect, Color

  • Color-Vision Disease

  • Dyschromatopsia
Eye Degenerative Disease
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Macular Degeneration, Age-Related, 1

  • Macular Degeneration

  • Age-Related Macular Degeneration

  • Macular Degeneration, Age-Related

  • Age Related Macular Degeneration

  • Age Related Macular Degeneration 1

  • ARMD1

  • Senile Macular Degeneration

  • Maculopathy, Age-Related, 1

  • Macular Degeneration, Age-Related, Reduced Risk Of

  • Age Related Maculopathy 1

  • Age Related Maculopathies

  • Age Related Maculopathy

  • Senile Macular Retinal Degeneration

  • Macular Degeneration Of Retina

  • Age-Related Maculopathy

  • Amd

  • Armd

  • Age-Related Maculopathy, Susceptibility To

  • Maculopathy Age-Related

  • Macular Degeneration, Age-Related, 1, Susceptibility To

  • Maculopathy, Age-Related

  • Macular Degeneration, Age-Related, Type 1

  • Macular Degeneration, Age-Related, 2
Stargardt Disease

  • Stargardt Disease 1

  • Stargardt Macular Dystrophy

  • Stargardt Disease-1

  • Juvenile Onset Macular Degeneration

  • Stargardt Macular Degeneration

  • Juvenile Macular Degeneration

  • Macular Dystrophy With Flecks, Type 1

  • Stgd

  • Fundus Flavimaculatus

  • Stargardt 1

  • Stargardts Disease
Cone Dystrophy

  • Retinal Cone Dystrophy

  • Dystrophy, Cone

  • Cone Dystrophy 3
Vitelliform Macular Dystrophy

  • Best Disease

  • Juvenile-Onset Vitelliform Macular Dystrophy

  • Macular Dystrophy, Vitelliform

  • Best Macular Dystrophy

  • Vitelliform Dystrophy
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Usher Syndrome Type 2

  • Ush2

  • Usher Syndrome Type Ii
Usher Syndrome

  • Deafness-Retinitis Pigmentosa Syndrome

  • Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

  • Graefe-Usher Syndrome

  • Hallgren Syndrome

  • Usher'S Syndrome

  • Retinitis Pigmentosa-Deafness Syndrome

  • Retinitis Pigmentosa-Hearing Loss Syndrome

  • Ush

  • Usher Syndromes
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Joubert Syndrome 1

  • Joubert Syndrome

  • Jbts

  • Cerebellooculorenal Syndrome 1

  • JBTS1

  • Joubert-Boltshauser Syndrome

  • Cerebelloparenchymal Disorder Iv

  • Cpd4

  • Cors1

  • Joubert Syndrome And Related Disorders

  • Jsrd

  • Familial Aplasia Of The Vermis

  • Joubert Syndrome Related Disorders

  • Js

  • Cerebellar Vermis Agenesis

  • Cerebelloparenchymal Disorder 4

  • Agenesis Of Cerebellar Vermis

  • Cerebello-Oculo-Renal Syndrome

  • Cors

  • Joubert-Bolthauser Syndrome

  • Cpd Iv

  • Classic Joubert Syndrome

  • Joubert Syndrome Type A

  • Pure Joubert Syndrome

  • Cerebello-Oculo-Renal Syndrome 1

  • Joubert Syndrome-1

  • Joubert Syndrome, Type 1

  • Joubert'S Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103045 CMPD101 Inhibitor 99.49% Unkown
HY-142812 GRK6-IN-1 99.61% Unkown
HY-18991 CCG215022 Inhibitor 99.79% Unkown
HY-109562A CCG258208 hydrochloride 98.05% Unkown
HY-139690 CCG258747 98.96% Unkown
HY-109562 CCG258208 Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-119232 GSK466317A Inhibitor / Unkown
HY-120168 CCG 258001 Inhibitor / Unkown
HY-RS05812 GRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GRK1 VGNC VGNC:62717
Macaca mulatta GRK1 VGNC VGNC:73160
Rattus norvegicus GRK1 RGD RGD:619712
Canis familiaris GRK1 VGNC VGNC:41501
Mus musculus GRK1 MGD MGI:1345146
Bos taurus GRK1 VGNC VGNC:29654
Others GRK1 NCBI