GRK1 Antibody
(Synonyms: RHOK, GRK1, Rhodopsin kinase GRK1, RK, G protein-coupled receptor kinase 1)GRK1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GRK1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
GRK1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GRK1.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 64 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 63 kDa
Synthetic peptide of human GRK1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
GRK1 is a Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity)[1].
-
Subcellular Localization
Membrane; Cell projection, cilium, photoreceptor outer segment
-
Expression
Tissue_Specificity: Retinal-specific. Expressed in rods and cones cells. -
Isoforms & Post-Translational Modification
GRK1 has an amino acid length of 563, molecular weight is 63526 Da.
Phosphorylation at Ser-21 is regulated by light and activated by cAMP. -
Subunit
Interacts (via N-terminus) with RCVRN (via C-terminus); the interaction is Ca(2+)-dependent (By similarity).
-
SwissProt ID
-
Synonyms
RHOK, GRK1, Rhodopsin kinase GRK1, RK, G protein-coupled receptor kinase 1
Documentation
Powered by Bioz
