2. GPCR/G Protein
  3. G Protein-coupled Receptor Kinase (GRK)
  4. CCG 258001

CCG 258001 is a GRK inhibitor with IC50 values of 0.29, 51.8, and 33 µM against GRK2, GRK1, and GRK5, respectively. CCG 258001 inhibits GRK activity in cardiomyocytes and other muscle cells. CCG 258001 is applicable to the research of heart diseases, including heart failure, myocardial hypertrophy, and hypertension.

For research use only. We do not sell to patients.

CCG 258001

CCG 258001 Chemical Structure

CAS No. : 2055990-96-8

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CCG 258001 Related Antibodies

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Description

CCG 258001 is a GRK inhibitor with IC50 values of 0.29, 51.8, and 33 µM against GRK2, GRK1, and GRK5, respectively. CCG 258001 inhibits GRK activity in cardiomyocytes and other muscle cells. CCG 258001 is applicable to the research of heart diseases, including heart failure, myocardial hypertrophy, and hypertension[1].

IC50 & Target[1]

GRK2

0.29 μM (IC50)

GRK5

33 μM (IC50)

In Vitro

CCG 258001 (5 min) potently inhibits GRK2 with an IC50 of 0.29 µM, while it shows weak inhibitory effects on GRK1 and GRK5[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCG 258001 Related Antibodies
Molecular Weight

339.41

Formula

C20H22FN3O
CAS No.
SMILES

C(OC=1C=C2C(=CC1)NN=C2)[C@H]3[C@@H](CCN(C)C3)C4=CC=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CCG 258001 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCG 2580012055990-96-8CCG258001CCG-258001G Protein-coupled Receptor Kinase (GRK)GRK inhibitorheart failuremyocardial hypertrophyhypertensionInhibitorinhibitorinhibit

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