Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

Also Known as ALDOS; Cp45as; Cyp11b3; RNCP45AS

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24294

Summary

Enables corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Involved in several processes, including cellular response to nutrient levels; response to peptide hormone; and steroid biosynthetic process. Located in dendrite. Used to study heart disease; hypertension; and myocardial infarction. Biomarker of congestive heart failure; hypertension; myocarditis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (Cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11b2 Products (1)

mRNA	Protein	Name
NM_012538.2	NP_036670.2	cytochrome P450 11B2, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables corticosterone 18-monooxygenase activity	IDA IDA: Inferred from direct assay	2350348	RGD
enables steroid 11-beta-monooxygenase activity	IDA IDA: Inferred from direct assay	8333830	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in C21-steroid hormone biosynthetic process	IDA IDA: Inferred from direct assay	11832364	RGD
involved in aldosterone biosynthetic process	IDA IDA: Inferred from direct assay	11832364	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19478813	RGD
involved in cellular response to nutrient	IEP IEP: Inferred from expression pattern	16876110	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	20685870	RGD
involved in cellular response to potassium ion starvation	IEP IEP: Inferred from expression pattern	20685870	RGD
involved in glucocorticoid biosynthetic process	IDA IDA: Inferred from direct assay	11832364	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18495825	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	16043663	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16882930	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18252953	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	19118098	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16043663	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in dendrite	IDA IDA: Inferred from direct assay	12459034	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytochrome P450 11B2, mitochondrial	CYPXIB2 CYPXIB3 Cytochrome P450, subfamily XIB, polypeptide 2 (aldosterone synthase) P450-Aldo-1 P450-Aldo-2 aldosterone synthase aldosterone-synthesizing enzyme corticosterone 18-monooxygenase, CYP11B2 cytochrome P-450Aldo cytochrome P-450C18 c

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16276	Osilodrostat	Inhibitor	99.90%	Yes
HY-16276A	Osilodrostat phosphate	Inhibitor	98.83%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-163689	Vicadrostat	Inhibitor	98.67%	Phase 3
HY-19833	Lapiteronel	Inhibitor	98.51%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113151	18-Oxocortisol	Antagonist	99.05%	Unkown
HY-W002108	3,4-Dihydroquinolin-2(1H)-one		≥95.0%	Unkown
HY-113986	Dexfadrostat	Inhibitor	98.75%	Unkown
HY-101217	BI 689648	Inhibitor	99.20%	Unkown
HY-135281	CYP11B2-IN-1	Inhibitor	99.83%	Unkown
HY-155493	CYP19A1/CYP11B2-IN-1	Inhibitor	99.85%	Unkown
HY-113986C	Dexfadrostat hydrochloride	Inhibitor	/	Unkown
HY-122744	CYP11B1-IN-1	Inhibitor	/	Unkown
HY-176480	CYP11B2-IN-3	Inhibitor	/	Unkown
HY-RS03436	CYP11B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162574	CYP11B2-IN-2	Inhibitor	/	Unkown
HY-163751	STING-IN-9	Inhibitor	/	Unkown
HY-RS17177	Cyp11b2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23627	Cyp11b2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp11b2	NCBI	NCBI:1585