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Egr1 - early growth response 1 Gene

Also Known as Ngf1; Ngfi; NGFI-A; Krox-24; zif-268

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24330

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II core promoter sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to organonitrogen compound; positive regulation of macromolecule metabolic process; and regulation of synaptic plasticity. Located in cytoplasm and nucleus. Biomarker of several diseases, including liver cirrhosis; lung disease (multiple); middle cerebral artery infarction; pulmonary hypertension; and visual epilepsy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human EGR1 (early growth response 1). [provided by Alliance of Genome Resources, Apr 2022]

Egr1 Products (1)

mRNA	Protein	Name
NM_012551.3	NP_036683.2	early growth response protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12021067	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	16849326	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15220929	RGD
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21451041	RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21257751	RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14979875	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	10837920	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22292946	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10837920	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	21490970	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	12021067	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	12021067	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	12021067	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	21489990	RGD
involved in cellular response to heparin	IDA IDA: Inferred from direct assay	8910451	RGD
involved in cellular response to hyperoxia	IEP IEP: Inferred from expression pattern	15734424	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	21220915	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	12970165	RGD
involved in cellular response to isoquinoline alkaloid	IEP IEP: Inferred from expression pattern	16448624	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	16998809	RGD
involved in cellular response to mycophenolic acid	IDA IDA: Inferred from direct assay	18723570	RGD
involved in cellular response to steroid hormone stimulus	IEP IEP: Inferred from expression pattern	21257751	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	21354245	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	21363938	RGD
involved in glomerular mesangial cell proliferation	IMP IMP: Inferred from mutant phenotype	18723570	RGD
involved in learning or memory	IEP IEP: Inferred from expression pattern	12486186	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	16930406	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	22906840	RGD
involved in long-term synaptic potentiation	IEP IEP: Inferred from expression pattern	21425206	RGD
involved in oligodendrocyte differentiation	IEP IEP: Inferred from expression pattern	21490970	RGD
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16849326	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21451041	RGD
involved in positive regulation of glomerular metanephric mesangial cell proliferation	IMP IMP: Inferred from mutant phenotype	8910451	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21451041	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	23973488	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	23973488	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12021067	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16849326	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16930406	RGD
involved in regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	23164821	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	21229349	RGD
involved in response to carbon monoxide	IEP IEP: Inferred from expression pattern	16551742	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	21334415	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	21334415	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	11751152	RGD
involved in response to follicle-stimulating hormone	IEP IEP: Inferred from expression pattern	12554779	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	12554779	RGD
involved in response to ischemia	IDA IDA: Inferred from direct assay	1859855	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	30550948	RGD
involved in response to norepinephrine	IEP IEP: Inferred from expression pattern	7905536	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21430247	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	7905536	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8910451	RGD
located in nucleus	IDA IDA: Inferred from direct assay	1859855	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
early growth response protein 1	nerve growth factor-induced protein A transcription factor Zif268 zinc finger protein Krox-24

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157549A	Brivoligide sodium		99.37%	Phase 2
HY-157549	Brivoligide		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163731	EGR-1-IN-1	Inhibitor	99.07%	Unkown
HY-W286743	Nε-(Carboxymethyl)-L-lysine	Activator	99.70%	Unkown
HY-202699	SHOC2-RAS PPI-IN-1	Inhibitor	99.50%	Unkown
HY-169118	EGR-1-IN-2	Inhibitor	99.61%	Unkown
HY-121246	Fluorofenidone	Inhibitor	99.78%	Unkown
HY-116818	Crebinostat	Inhibitor	98.83%	Unkown
HY-170415	EGR-1-IN-3	Inhibitor	99.13%	Unkown
HY-125980	LX-3	Inhibitor	98.08%	Unkown
HY-RS04215	EGR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-146411	microRNA-21-IN-1		98.03%	Unkown
HY-RS16606	Egr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-131721	14,15-EET-SI	Activator	/	Unkown
HY-180419	SF-3-030		/	Unkown
HY-121246S	Fluorofenidone-d3	Inhibitor	/	Unkown
HY-RS23040	Egr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990661	SAIT-301	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Egr1	NCBI	NCBI:1958