Pkd1l3 - polycystic kidney disease 1 like 3 Gene

Mus musculus

Gene ID: 244646 | Gene type: protein coding

About Pkd1l3

Summary

Contributes to cation channel activity and sour Taste Receptor activity. Involved in cation transport; cellular response to acidic pH; and detection of chemical stimulus involved in sensory perception of sour taste. Part of cation channel complex and receptor complex. Colocalizes with cell surface. Is expressed in circumvallate papilla; cochlea; foliate papillae; and testis. Orthologous to human PKD1L3 (polycystin 1 like 3, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Apr 2022]

Pkd1l3 Products(3)

mRNA	Protein	Name
NM_001039700.3	NP_001034789.2	polycystic kidney disease protein 1-like 3 isoform a precursor
NM_001286454.2	NP_001273383.1	polycystic kidney disease protein 1-like 3 isoform c precursor
NM_181544.3	NP_853522.2	polycystic kidney disease protein 1-like 3 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to monoatomic cation channel activity	IDA IDA: Inferred from direct assay	16891422	MGI
contributes to monoatomic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	16891422	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16891422	MGI
contributes to sour taste receptor activity	IDA IDA: Inferred from direct assay	16891422	MGI
NOT enables sour taste receptor activity	IMP IMP: Inferred from mutant phenotype	20605874	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16891422	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	16891422	MGI
NOT involved in cellular response to acidic pH	IMP IMP: Inferred from mutant phenotype	20605874	MGI
involved in detection of chemical stimulus involved in sensory perception of sour taste	IDA IDA: Inferred from direct assay	16891422	MGI
NOT involved in detection of chemical stimulus involved in sensory perception of sour taste	IMP IMP: Inferred from mutant phenotype	20605874	MGI
involved in monoatomic cation transport	IDA IDA: Inferred from direct assay	16891422	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of cation channel complex	IDA IDA: Inferred from direct assay	16891422	MGI
colocalizes with cell surface	IDA IDA: Inferred from direct assay	16891422	MGI
part of receptor complex	IDA IDA: Inferred from direct assay	16891422	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polycystic kidney disease protein 1-like 3

PC1-like 3 protein

polycystin-1L3

Pkd1l3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Pkd1l3	Q2EG98	Pkd2l1	Mus musculus	A2A259	Anti Tag CoIP	16891422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00007	PKD1L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pkd1l3	NCBI	NCBI:342372

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