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FUT6 - fucosyltransferase 6 Gene

Also Known as FT1A; FCT3A; Fuc-TVI; FucT-VI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2528

About FUT6

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,830,408-5,839,702 (from NCBI)

This gene has 11 transcripts (splice variants), 380 orthologues, 7 paralogues and is associated with 1 phenotype. Biased expression in kidney (RPKM 17.3), esophagus (RPKM 12.2) and 8 other tissues.

Summary

The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-Selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

FUT6 Products (10)

mRNA	Protein	Name
NM_000150.4	NP_000141.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001040701.2	NP_001035791.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001369502.1	NP_001356431.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001369504.1	NP_001356433.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001369505.1	NP_001356434.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001381955.1	NP_001368884.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001381956.1	NP_001368885.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 1
NM_001381957.1	NP_001368886.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2
NM_001381958.1	NP_001368887.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2
NM_001381959.1	NP_001368888.1	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: Inferred from direct assay	9363434	GOA
enables fucosyltransferase activity	IDA IDA: Inferred from direct assay	17604274	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-glycan fucosylation	IDA IDA: Inferred from direct assay	9363434	GOA
involved in ceramide metabolic process	IDA IDA: Inferred from direct assay	17604274	GOA
involved in glycosphingolipid biosynthetic process	IDA IDA: Inferred from direct assay	29593094	GOA
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	29593094	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	9451035	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	9451035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FUT6 Protein Structure

Glyco_transf_10

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	alpha-(1,3)-fucosyltransferase 6

Related Diseases

Diseases	Alias
Fucosyltransferase 6 Deficiency
Lipodystrophy, Congenital Generalized, Type 2	Congenital Generalized Lipodystrophy Type 2 CGL2 Berardinelli-Seip Congenital Lipodystrophy Type 2 Berardinelli-Seip Syndrome Brunzell Syndrome Bscl2-Related Total Lipodystrophy And Acromegaloid Gigantism Berardinelli-Seip Congenital Lipodystrophy, Type 2 Seip Syndrome Berardinelli Syndrome Lipodystrophy, Total, And Acromegaloid Gigantism Lipoatrophic Diabetes, Congenital Lipodystrophy, Berardinelli-Seip Congenital, Type 2 Brunzell Syndrome, Bscl2-Related Congenital Lipoatrophic Diabetes Congenital Generalized Lipodystrophy 2 Lipoatrophic Diabetes Lipodystrophy Berardinelli Type Familial Generalized Lipodystrophy Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70303	Fucosyltransferase 6		/	Unkown
HY-RS05157	FUT6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FUT6	RGD	RGD:1588473