UBE2S - ubiquitin conjugating enzyme E2 S Gene
Also Known as EPF5; E2EPF; E2-EPF
Species: Homo sapiens
About UBE2S
This gene has 4 transcripts (splice variants), 197 orthologues and 24 paralogues. Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues.
Summary
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
UBE2S Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_014501.3 | NP_055316.2 | ubiquitin-conjugating enzyme E2 S |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables anaphase-promoting complex binding |
IPI
IPI: Inferred from physical interaction
|
23708001 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
23708001 | GOA |
| enables ubiquitin conjugating enzyme activity |
IDA
IDA: Inferred from direct assay
|
21376237 | GOA |
| contributes to ubiquitin-protein transferase activity |
IDA
IDA: Inferred from direct assay
|
19820702 | GOA |
| enables ubiquitin-protein transferase activity |
IDA
IDA: Inferred from direct assay
|
20061386 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of anaphase-promoting complex |
IDA
IDA: Inferred from direct assay
|
19822757 | GOA |
UBE2S Protein Structure
UQ_con: Ubiquitin-conjugating enzyme (16 - 149)
- 0
- 100
- 200
- 222 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ubiquitin-conjugating enzyme E2 S |
|
UBE2S Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
UBE2S | Q16763 | GNB2 | Homo sapiens | P62879 | 32814053 | |
|
Intra
|
UBE2S | Q16763 | GNB2 | Homo sapiens | P62879 | 32814053 | |
|
Intra
|
UBE2S | Q16763 | GNB2 | Homo sapiens | P62879 | 32814053 | |
|
Intra
|
UBE2S | Q16763 | ANAPC2 | Homo sapiens | Q9UJX6 | 23708001 |
Recombinant UBE2S Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71408 | UBE2S Protein, Human (GST) | Q16763 (M1-L222) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language |
|
|
| Liddle Syndrome 1 |
|
|
| Juvenile-Onset Parkinson'S Disease |
|
|
| Uterine Adnexa Cancer |
|
|
| Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1 |
|
|
| Cortical Dysplasia, Complex, With Other Brain Malformations 6 |
|
|
| Parkinson Disease, Late-Onset |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | UBE2S | VGNC | VGNC:48065 |
| Macaca mulatta | UBE2S | VGNC | VGNC:79099 |
| Felis catus | UBE2S | VGNC | VGNC:107073 |
| Bos taurus | UBE2S | VGNC | VGNC:36595 |
| Rattus norvegicus | UBE2S | RGD | RGD:1564746 |
| Mus musculus | UBE2S | MGD | MGI:1925141 |
| Others | UBE2S | NCBI |