UBE2S - ubiquitin conjugating enzyme E2 S Gene

Also Known as EPF5; E2EPF; E2-EPF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27338

About UBE2S

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,399,745-55,407,788 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 24 paralogues. Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues.

Summary

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

UBE2S Products (1)

mRNA Protein Name
NM_014501.3 NP_055316.2 ubiquitin-conjugating enzyme E2 S
Molecular Function GO Annotation Evidence References Source
enables anaphase-promoting complex binding IPI
IPI: Inferred from physical interaction
23708001 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23708001 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
21376237 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
19820702 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
20061386 GOA
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
19820702 GOA
involved in exit from mitosis IDA
IDA: Inferred from direct assay
19820702 GOA
involved in exit from mitosis IMP
IMP: Inferred from mutant phenotype
19822757 GOA
involved in free ubiquitin chain polymerization IDA
IDA: Inferred from direct assay
19822757 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19820702 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
27910872 GOA
acts upstream of or within protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
21376237 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
19822757 GOA
involved in protein K27-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K29-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
20061386 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
19822757 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2S Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (16 - 149)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 S

  • E2 ubiquitin-conjugating enzyme S

UBE2S Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2S Q16763 GNB2 Homo sapiens P62879 32814053
Intra
UBE2S Q16763 GNB2 Homo sapiens P62879 32814053
Intra
UBE2S Q16763 GNB2 Homo sapiens P62879 32814053
Intra
UBE2S Q16763 ANAPC2 Homo sapiens Q9UJX6 23708001
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2S Proteins

Cat. No. Product Name Accession Purity
HY-P71408 UBE2S Protein, Human (GST) Q16763 (M1-L222) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language
  • Chromosome 5q14.3 Deletion Syndrome

  • 5q14.3 Microdeletion Syndrome

  • Mental Retardation, Autosomal Dominant 20

  • NEDHSIL

  • Autosomal Dominant Mental Retardation 20

  • Mrd20

  • Del(5)(Q14.3)

  • Monosomy 5q14.3

  • Intellectual Disability, Autosomal Dominant 20

  • Mental Retardation, Autosomal Dominant 20, Formerly

  • Mrd20, Formerly

  • Mental Retardation, Stereotypic Movements, Epilepsy, And/Or Cerebral Malformations

  • 5q14.3 Deletion Syndrome

  • Autosomal Dominant Intellectual Disability 20

  • Mental Retardation, Autosomal Dominant, Type 20

Liddle Syndrome 1
  • Liddle Syndrome

  • Pseudoaldosteronism

  • Liddle'S Syndrome

  • LIDLS1

  • Lidls

  • Pseudohyperaldosteronism

  • Pseudoprimary Hyperaldosteronism

  • Pseudohyperaldosteronism Type 1

  • Liddles Syndrome

Juvenile-Onset Parkinson'S Disease
  • Juvenile-Onset Parkinson Disease

Uterine Adnexa Cancer
Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1
  • Hypophosphatemic Nephrolithiasis/Osteoporosis 1

  • NPHLOP1

  • Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1

  • Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1

Cortical Dysplasia, Complex, With Other Brain Malformations 6
  • Complex Cortical Dysplasia With Other Brain Malformations 6

  • CDCBM6

  • Cdcbm56

  • Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Parkinson Disease, Late-Onset
  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris UBE2S VGNC VGNC:48065
Macaca mulatta UBE2S VGNC VGNC:79099
Felis catus UBE2S VGNC VGNC:107073
Bos taurus UBE2S VGNC VGNC:36595
Rattus norvegicus UBE2S RGD RGD:1564746
Mus musculus UBE2S MGD MGI:1925141
Others UBE2S NCBI