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Ucn - urocortin Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29151

Summary

Enables corticotropin-releasing hormone receptor 1 binding activity; corticotropin-releasing hormone receptor 2 binding activity; and histone deacetylase inhibitor activity. Involved in several processes, including negative regulation of cell death; positive regulation of macromolecule metabolic process; and regulation of secretion. Located in axon; dendrite; and perikaryon. Used to study Parkinsonism and thromboangiitis obliterans. Biomarker of asthma; colitis; and thromboangiitis obliterans. Orthologous to human UCN (urocortin). [provided by Alliance of Genome Resources, Apr 2022]

Ucn Products (1)

mRNA	Protein	Name
NM_019150.2	NP_062023.1	urocortin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor binding	IDA IDA: Inferred from direct assay	11784785	RGD
enables corticotropin-releasing hormone receptor 1 binding	IPI IPI: Inferred from physical interaction	15049707	RGD
enables corticotropin-releasing hormone receptor 2 binding	IPI IPI: Inferred from physical interaction	7477349	RGD
enables histone deacetylase inhibitor activity	IDA IDA: Inferred from direct assay	19875195	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7477349	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase A activity	IDA IDA: Inferred from direct assay	19460778	RGD
involved in aerobic respiration	IDA IDA: Inferred from direct assay	11597609	RGD
involved in associative learning	IDA IDA: Inferred from direct assay	10366634	RGD
involved in drinking behavior	IMP IMP: Inferred from mutant phenotype	10751559	RGD
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	10751559	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17391780	RGD
involved in learning or memory	IDA IDA: Inferred from direct assay	12376180	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	14519439	RGD
involved in negative regulation of appetite	IDA IDA: Inferred from direct assay	21540451	RGD
involved in negative regulation of blood pressure	IDA IDA: Inferred from direct assay	15604589	RGD
involved in negative regulation of cell size	IDA IDA: Inferred from direct assay	19460778	RGD
involved in negative regulation of feeding behavior	IDA IDA: Inferred from direct assay	11597609	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	14563694	RGD
involved in negative regulation of hormone secretion	IDA IDA: Inferred from direct assay	21540451	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	11784785	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	15078549	RGD
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	11784785	RGD
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	11087261	RGD
involved in positive regulation of behavioral fear response	IDA IDA: Inferred from direct assay	10366634	RGD
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	7477349	RGD
involved in positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	16513211	RGD
involved in positive regulation of cardiac muscle contraction	IDA IDA: Inferred from direct assay	19460778	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	15694367	RGD
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	11087261	RGD
involved in positive regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	7477349	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	21540451	RGD
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	12746280	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19875195	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	14519439	RGD
involved in positive regulation of translation	IDA IDA: Inferred from direct assay	11087261	RGD
involved in positive regulation of vascular permeability	IDA IDA: Inferred from direct assay	19819946	RGD
involved in regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	15102917	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16672665	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	16427607	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	11784785	RGD
involved in response to pain	IEP IEP: Inferred from expression pattern	21463663	RGD
involved in social behavior	IDA IDA: Inferred from direct assay	16488545	RGD
involved in vasodilation	IDA IDA: Inferred from direct assay	15467262	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	12379245	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	12379245	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12379245	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12379245	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	10553117	RGD
located in varicosity	IDA IDA: Inferred from direct assay	15796765	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
urocortin	corticotensin

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13661	7-Hydroxystaurosporine		97.8%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1858A	Urocortin III, mouse TFA	Activator	98.06%	Unkown
HY-105416	Calphostin C	Inhibitor	99.9%	Unkown
HY-108262	UCN-02	Inhibitor	≥98.0%	Unkown
HY-P1858	Urocortin III, mouse	Activator	98.29%	Unkown
HY-RS15407	UCN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15408	UCN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15409	UCN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17732	Ucn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21451	Ucn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24197	Ucn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27969	Ucn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ucn	NCBI	NCBI:7349