CFH - complement factor H Gene

Also Known as FH; HF; HF1; HF2; HUS; FHL1; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3075

About CFH

Cytogenetic location: 1q31.3 Genomic coordinates (GRCh38): 1:196,652,043-196,747,504 (from NCBI)

This gene has 39 transcripts (splice variants), 19 orthologues, 39 paralogues and is associated with 12 phenotypes. Biased expression in liver (RPKM 390.3), gall bladder (RPKM 78.0) and 9 other tissues.

Summary

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]

CFH Products (2)

mRNA	Protein	Name
NM_000186.4	NP_000177.2	complement factor H isoform a precursor
NM_001014975.3	NP_001014975.1	complement factor H isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparan sulfate proteoglycan binding	IDA IDA: Inferred from direct assay	22471560	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	22471560	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19505476	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16612335	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in complement activation	IDA IDA: Inferred from direct assay	24835392	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	28671664	GOA
acts upstream of or within regulation of complement activation	IDA IDA: Inferred from direct assay	25284781	GOA
involved in regulation of complement activation, alternative pathway	IDA IDA: Inferred from direct assay	20378178	GOA
acts upstream of or within regulation of complement-dependent cytotoxicity	IDA IDA: Inferred from direct assay	25284781	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of serine-type endopeptidase complex	IPI IPI: Inferred from physical interaction	28671664	GOA
located in symbiont cell surface	IDA IDA: Inferred from direct assay	23332154	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CFH Protein Structure

Sushi

0
200
400
600
800
1000
1231 a.a.

Protein Preferred Names	Protein Names
complement factor H	H factor 1 (complement)

CFH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CFH	P08603	PTX3	Homo sapiens	P26022	Solid Phase Assay	19050261
Intra	CFH	P08603	APOE	Homo sapiens	P02649	MST	26468283
Intra	CFH	P08603	APOE	Homo sapiens	P02649	Solid Phase Assay	26468283
Intra	CFH	P08603	APOE	Homo sapiens	P02649	Pull Down	26468283
Intra	CFH	P08603	APOE	Homo sapiens	P02649	ELISA	26468283
Intra	CFH	P08603	CRP	Homo sapiens	P02741	ELISA	17293598
Intra	CFH	P08603	CRP	Homo sapiens	P02741	SPR	19680263
Intra	CFH	P08603	CRP	Homo sapiens	P02741	ELISA	19680263
Intra	CFH	P08603	CRP	Homo sapiens	P02741	ELISA	28533443
Intra	CFH	P08603	CRP	Homo sapiens	P02741	Solid Phase Assay	17293598
Intra	CFH	P08603	CRP	Homo sapiens	P02741	SPR	17293598
Intra	CFH	P08603	CRP	Homo sapiens	P02741	ELISA	17339482
Intra	CFH	P08603	CRP	Homo sapiens	P02741	ELISA	19084272
Cross	CFH	P08603	fhbP	Neisseria meningitidis serogroup B	Q9JXV4	X-Ray Diffraction	19225461
Cross	CFH	P08603	fhbP	Neisseria meningitidis serogroup B	Q9JXV4	GMS	19225461
Cross	CFH	P08603	fhbP	Neisseria meningitidis serogroup B	Q9JXV4	Far-WB	19225461
Cross	CFH	P08603	fhbP	Neisseria meningitidis serogroup B	Q9JXV4	SPR	19225461
Intra	CFH	P08603	P02741-PRO_0000023526	Homo sapiens	P02741-PRO_0000023526	ELISA	17244159
Intra	CFH	P08603	P26022-PRO_0000023545	Homo sapiens	P26022-PRO_0000023545	Peptide Array	22786770
Cross	CFH	P08603	ennX	Streptococcus pyogenes serotype M49	P16946	Affinity Techniques	18627465
Intra	CFH	P08603	P01024-PRO_0000005908	Homo sapiens	P01024-PRO_0000005908	SPR	16612335
Intra	CFH	P08603	P01024-PRO_0000005908	Homo sapiens	P01024-PRO_0000005908	X-Ray Diffraction	28671664
Intra	CFH	P08603	P01024-PRO_0000005908	Homo sapiens	P01024-PRO_0000005908	Filter Binding	16612335
Cross	CFH	P08603	FMOD	Bos taurus	P13605	ELISA	17293598
Cross	CFH	P08603	FMOD	Bos taurus	P13605	SPR	17293598
Cross	CFH	P08603	FMOD	Bos taurus	P13605	Solid Phase Assay	17293598

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CFH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7890	Complement factor H/CFH Protein, Human (HEK293, His, solution)	P08603-2 (E19-L449)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72946	Complement factor H/CFH Protein, Human (372a.a, HEK293, His)	P08603-1 (S860-R1231)	≥ 95%, as determined by reducing SDS-PAGE.

CFH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83616	Factor H Antibody (YA3361)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Complement Factor H Deficiency	Factor H Deficiency CFHD Cfh Deficiency C3 Glomerulopathy 1 C3g1 Immunodeficiency With Factor H Anomaly Deficiency, Complement Factor H Membranoproliferative Glomerulonephritis, Type Ii
Hemolytic Uremic Syndrome, Atypical 1	Atypical Hemolytic-Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1 Atypical Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome, Atypical, Susceptibility To Ahus AHUS1 Hemolytic-Uremic Syndrome Ahus 1 Ahus, Susceptibility To, 1 Hemolytic Uremic Syndrome, Atypical Non-Shiga-Like Toxin-Associated Hus Non-Stx-Hus Nonenteropathic Hus Atypical Hus Shiga Toxin-Associated Hemolytic Uremic Syndrome D+ Hus Ehec-Hus Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli Hemolytic Uremic Syndrome With Diarrhea Stec-Hus Shiga-Like Toxin-Associated Hus Stx-Hus Typical Hus Typical Hemolytic Uremic Syndrome Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies Atypical Hus With Anti-Factor H Antibodies Ahus With Anti-Factor H Antibodies Ahus With Neutralizing Autoantibodies Against Factor H Hemolytic Uremic Syndrome Atypical 1 Atypical Hemolytic Uremic Syndrome With H Factor Anomaly D Hus Hemolytic-Uremic Syndrome Without Diarrhea Hemolytic-Uremic Syndrome, Atypical, Type 1 Hemolytic Uremic Syndrome, Typical
Macular Degeneration, Age-Related, 4	Age Related Macular Degeneration 4 ARMD4 Macular Degeneration, Age-Related, Type 4
Basal Laminar Drusen	Drusen Of Bruch Membrane Drusen, Cuticular Drusen, Early Adult-Onset, Grouped Cuticular Drusen Early Adult-Onset Grouped Drusen BLD Drusen Cuticular Drusen Early Adult-Onset Grouped
Membranoproliferative Glomerulonephritis	Mesangiocapillary Glomerulonephritis Dense Deposit Disease Membranoproliferative Glomerulonephritis Type 2 Primary Membranoproliferative Glomerulonephritis Mesangiocapillary Glomerulonephritis, Type Ii Glomerulonephritis, Membranoproliferative Chronic Glomerulonephritis, Lobular Lobular Glomerulonephritis Ddd Glomerulonephritis Membranoproliferative Type 2 Mpgn 2 Membranoproliferative Glomerulonephritis Type Ii Mesangiocapillary Glomerulonephritis Type 2 Mpgn Primary Mpgn Glomerulonephritis Membranoproliferative Membranoproliferative Glomerulonephritis, Type Ii
D-Minus Hemolytic Uremic Syndrome	Atypical Hus Atypical Hemolytic Uremic Syndrome Hus, Atypical Ahus
Nephrotic Syndrome, Type 7	Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7 NPHS7 Nephrotic Syndrome Type 7 Ig-Mediated Membranoproliferative Glomerulonephritis Ig-Mediated Mpgn Immunoglobulin-Mediated Mpgn Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis Hemolytic Uremic Syndrome, Atypical 7 Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis Hemolytic Uremic Syndrome With Dgke Deficiency Hus With Dgke Deficiency Hemolytic Uremic Syndrome Atypical 7 AHUS7 Nephrotic Syndrome 7 Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
Familial Drusen	Malattia Leventinese Doyne Honeycomb Retinal Dystrophy Dhrd Dominant Drusen Dominant Radial Drusen
Atypical Hemolytic Uremic Syndrome With Complement Gene Abnormality	Atypical Hus With Complement Gene Abnormality Ahus With Complement Gene Abnormality
Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome Haemolytic-Uraemic Syndrome Hus Acute Renal Failure, Thrombocytopenia, And Microangiopathic Hemolytic Anemia Associated With Distorted Erythrocytes Typical Haemolytic Uraemic Syndrome Gasser Syndrome Hus - [Haemolytic Uraemic Syndrome]
De Novo Thrombotic Microangiopathy After Kidney Transplantation
Relapsing Fever	Febris Recurrens Novy Febris Recurrens Novy Relapsing Fever
Retinal Drusen
Hellp Syndrome	Hemolysis, Elevated Liver Enzymes, Lowered Platelets Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet] Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Choroiditis	Posterior Uveitis
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Lyme Disease	Lyme Borreliosis Lyme Neuroborreliosis Borreliosis Borrelia Burgdorferi Infection Neuroborreliosis Bannwarth Syndrome Bannworth'S Syndrome Neurological Lyme Disease B. Burgdorferi Infection Borreliosis, Lyme Infection By Borrelia Burgdorferi Infection Due To Borrelia Burgdorferi Sensu Lato Lym Borrelia Infections
Central Serous Chorioretinopathy	Central Serous Chorioretinopathy After Bone Marrow Transplantation Central Serous Choroidopathy Cscr Central Serous Retinopathy Central Serous Choroidoretinopathy
Glomerulonephritis	Bright'S Disease
Collagen Type Iii Glomerulopathy	Collagenofibrotic Glomerulopathy
Spirochetes Disease	Spirochaetales Infections
Thrombotic Thrombocytopenic Purpura, Hereditary	Upshaw-Schulman Syndrome Microangiopathic Hemolytic Anemia Thrombotic Microangiopathy, Familial Uss Schulman-Upshaw Syndrome Thrombotic Thrombocytopenic Purpura, Familial Congenital Thrombotic Thrombocytopenic Purpura TTP Thrombotic Thrombocytopenic Purpura, Congenital Upshaw Factor, Deficiency Of Microangiopathic Hemolytic Anemia, Congenital Thrombotic Thrombocytopenic Purpura, Hereditary, Infantile- Or Adult-Onset Ttp, Congenital Congenital Adamts-13 Deficiency Congenital Ttp Familial Ttp Upshaw-Schülman Syndrome Deficiency Of Upshaw Factor Microangiopathic Hemolytic Anemia Congenital Moschkowitz Disease Thrombotic Microangiopathy Familial Thrombotic Thrombocytopenic Purpura Familial Anemia Hemolytic Microangiopathic Purpura, Thrombotic Thrombocytopenic
Thrombotic Thrombocytopenic Purpura	Purpura, Thrombotic Thrombocytopenic Ttp Thrombotic Thrombocytopenic Purpura, Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Moschcowitz Disease Moschcowitz'S Syndrome Moschowitz Syndrome Chronic Relapsing Thrombotic Thrombocytopenic Purpura Familial Thrombotic Thrombocytopenia Purpura Moschkowitz Disease Purpura Thrombotic Thrombocytopenic Familial Thrombotic Thrombocytopenic Purpura Microangiopathic Hemolytic Anemia Congenital Thrombotic Thrombocytopenic Purpura Autoimmune Thrombotic Thrombocytopenic Purpura Ttp - [Thrombotic Thrombocytopenic Purpura] Moschcowitz Syndrome
Degeneration Of Macula And Posterior Pole	Degeneration Of Macula And Posterior Pole Of Retina Degeneration Of Macula Or Posterior Pole Macular Degeneration Nos Degenerative Disorder Of Macula Drusen Macular Degeneration Posterior Pole Macular Degeneration Of Eye Macular Eye Degeneration Macular Degeneration Of Retina, Unspecified Pseudohole Degeneration Of Macula Of Retina
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Histoplasmosis	Darling Disease Reticuloendotheliosis, X-Linked Infection By Histoplasma Capsulatum Histoplasma Infection Reticuloendothelial Cytomycosis Cytomycosis Darling Histoplasmosis African Histoplasmosis Histoplasmosis Duboisii
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Antiphospholipid Syndrome	Antiphospholipid Antibody Syndrome Hughes Syndrome Familial Antiphospholipid Syndrome Aps Lupus Anticoagulant, Familial Anti-Phospholipid Syndrome Apls Classic Apls Classic Antiphospholipid Syndrome Acromegaloid Facial Appearance Syndrome Anticardiolipin Syndrome
Kuhnt-Junius Degeneration	Neovascular Age-Related Macular Degeneration Exudative Senile Macular Degeneration Of Retina Senile Macular Degeneration, Wet Wet Senile Macular Retinal Degeneration Exudative Age-Related Macular Degeneration Exudative Macular Degeneration
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Eye Degenerative Disease
Acute Kidney Failure	Acute Renal Failure Acute Kidney Injury Renal Failure Acute Kidney Failure, Acute Pre-Renal Acute Kidney Injury Nontraumatic Acute Kidney Injury Aki - [Acute Kidney Injury] Arf - [Acute Kidney Failure] Acute Kidney Disease Acute Kidney Impairment Acute Ischaemic Renal Failure Acute Hypoxic Kidney Failure Acute Kidney Shutdown Acute Renal Oedema Acute Renal Impairment Acute Kidney Collapse Acute Necrotising Kidney Acute Renal Suppression
Complement Deficiency	Complement Deficiency Disease Hereditary Complement Deficiency Diseases
Stargardt Disease	Stargardt Disease 1 Stargardt Macular Dystrophy Stargardt Disease-1 Juvenile Onset Macular Degeneration Stargardt Macular Degeneration Juvenile Macular Degeneration Macular Dystrophy With Flecks, Type 1 Stgd Fundus Flavimaculatus Stargardt 1 Stargardts Disease
C3 Glomerulopathy	C3 Glomerulonephritis C3g Non-Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis Glomerulonephritis With Dominant C3 Ddd Ddd/Mpgnii Dense Deposit Disease Membranoproliferative Glomerulonephritis Type Ii Non-Ig-Mediated Mpgn Non-Ig-Mediated Membranoproliferative Glomerulonephritis Non-Immunoglobulin-Mediated Mpgn Membranoproliferative Glomerulonephritis, Type Ii
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Haemophilus Influenzae
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Louse-Borne Relapsing Fever	Relapsing Fever, Louse-Borne Relapsing Fever Due To Borrelia Recurrentis
Malignant Hypertension	Hypertension, Malignant Hypertension Malignant
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Angioid Streaks
Methylmalonic Aciduria And Homocystinuria, Cblc Type	MAHCC Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic Methylmalonic Aciduria And Homocystinuria Type Cblc Cobalamin C Disease Methylmalonic Acidemia With Homocystinuria Cblc Methylmalonic Acidemia And Homocystinuria, Cblc Type Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive Cobalamin C Deficiency Methylmalonic Acidemia With Homocystinuria, Type Cblc Cblc Defect Cobalamin C Defect Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc Methylmalonic Aciduria With Homocystinuria, Type Cblc Methylmalonic Acidemia And Homocystinuria Cblc Type Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive Aciduria, Methylmalonic, And Homocystinuria, Cblc Type Methylmalonic Acidemia With Homocystinuria
Macular Dystrophy, Patterned, 3	Martinique Crinkled Retinal Pigment Epitheliopathy Patterned Macular Dystrophy 3 MDPT3 Mcrpe
Acute Poststreptococcal Glomerulonephritis	Post-Streptococcal Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Doyne Honeycomb Retinal Dystrophy	DHRD Doyne Honeycomb Degeneration Of Retina Dhd Malattia Leventinese Ml Mlvt Dystrophy, Retinal, Doyne Honeycomb
Cataract 23, Multiple Types	Cataract 23 CTRCT23 Lamellar Cataract 23 Cataract 23, Multiple Types, With Or Without Microcornea Isolated Microphthalmia With Cataract 4 Mcopct4 Cataract, Type 23 Microphthalmia, Isolated, With Cataract 4
Degenerative Myopia	Pathological Myopia Myopia, Degenerative Degenerative Progressive High Myopia Progressive High Myopia Progressive High Myopia
Meningococcal Meningitis	Meningitis, Meningococcal Meningitis Meningococcal Epidemic Meningitis Meningitis Due To Neisseria Meningitidis Meningococcal Meninges Infection Meningococcal Meningeal Infection Meningococcal Cerebrospinal Inflammation Chronic Meningococcal Arachnoiditis Meningococcal Arachnoiditis Diplococcal Spinal Meningitis Diplococcal Meningitis Meningococcal Cerebrospinal Fever Meningococcal Cerebrospinal Infection Meningococcal Spinal Meningitis
Sorsby Fundus Dystrophy	SFD Fundus Dystrophy, Pseudoinflammatory, Of Sorsby Sorsby'S Fundus Dystrophy Macular Dystrophy, Hemorrhagic Hemorrhagic Macular Dystrophy Pseudoinflammatory Fundus Dystrophy Of Sorsby Sorsby'S Pseudoinflammatory Macular Dystrophy Sorsby Pseudoinflammatory Fundus Dystrophy Dystrophy, Fundus, Sorsby
Proliferative Glomerulonephritis
Hypertensive Retinopathy
Complement Component 3 Deficiency	C3 Deficiency
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Retinal Disease	Retinal Diseases Retinal Disorder Retinal Disorders
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Immune-Complex Glomerulonephritis	Immune Complex Glomerulonephritis
Sensory System Disease
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Disseminated Chorioretinitis
Malaria	Malaria, Susceptibility To Malaria, Resistance To Malaria, Cerebral Cerebral Malaria Malaria, Severe, Susceptibility To Malaria, Severe, Resistance To Malaria, Cerebral, Susceptibility To Induced Malaria Malaria, Vivax, Protection Against Malaria, Severe Malaria, Cerebral, Reduced Risk Of Malaria, Protection Against Resistance To Malaria Due To G6pd Deficiency Malaria Due To G6pd Deficiency Malarial Encephalitis CM Malaria Cerebral Susceptibility To Malaria Acute Pernicious Fever Aestivo-Autumnal Fever Aestivo Autumnal Malaria Chagres Fever Continued Malaria Fever Estivo-Autumnal Fever Estivo-Autumnal Malaria Estivo-Autumnal Malarial Fever Falciparum Fever Malignant Tertian Fever Malignant Tertian Malaria Pernicious Intermittent Fever Pernicious Malaria Quotidian Malaria Subtertian Fever Subtertian Malaria Fever Subtertian Malignant Tertian Malaria Tropical Malaria Algid Malaria Bilious Haemoglobinuric Fever Black Water Fever Blackwater Fever Malarial Blackwater Fever Severe Malarial Falciparum West African Fever Malarial Haematinuria Haemoglobinuric Fever Haemoglobinuric Malaria Severe Plasmodium Falciparum Malaria Malarial Haemoglobinuria Malarial Haematuria Falciparum Malaria [Malignant Tertian] Malaria Tropica Malarial Shock Chagres Virus Disease Malignant Malaria Mtm - [Malignant Tertian Malaria] Tm -[Malignant Tertian Malaria] Panama Fever St - [Subtertian Malaria] Malarial Quotidian Benign Tertian Malaria Tertian Ague Vivax Fever Plasmodium Vivax Malaria Nos Btm - [Benign Tertian Malaria] Bt - [Benign Tertian Malaria] Vivax Malaria Benign Tertian Vivax Malaria Tertian Malaria Quartan Malaria Quartan Ague Quartan Fever Plasmodium Malariae Malaria Nos Quartan Malarial Malaria By Plasmodium Malariae Malariae Malaria Ovale Tertian Malaria Plasmodium Ovale Fever Malaria Fever By Plasmodium Ovale Ovale Malaria Malaria By Plasmodium Ovale Malarial Ovale Marsh Fever Remittent Congestive Fever Coastal Fever Remittent Gastric Fever Miasmatic Fever Congestive Remittent Fever Intermittent Fever Jungle Fever Paludism Cameroon Fever Ague Corsican Fever Intermittent Bilious Fever Disease Due To Plasmodiidae Malarial Fever Plasmodiosis Remittent Fever Roman Fever Malaria Fever Nos Malaria Nos Paludal Fever Clinically Diagnosed Malaria Clinically Diagnosed Malaria Without Parasitological Confirmation Congestive Fever Malarial Cachexia Marsh Cachexia Paludal Cachexia Recurrent Malaria Remittent Malaria
Lens Disease	Lens Diseases
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa
Methylmalonic Acidemia	Methylmalonic Aciduria Mma Acidemia, Methylmalonic Isolated Methylmalonic Acidemia
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Refractive Error	Refractive Errors
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Cardiomyopathy, Dilated, 1l	Dilated Cardiomyopathy 1l CMD1L Cardiomyopathy, Dilated 1l Cardiomyopathy, Dilated, Type 1l
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Complement Component 2 Deficiency	C2D C2 Deficiency Complement 2 Deficiency Complement Component-2
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991954	GT103	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02561	CFH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17522	Cfh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23978	Cfh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CFH	RGD	RGD:620428
Mus musculus	CFH	MGD	MGI:88385
Others	CFH	NCBI