IRF8 - interferon regulatory factor 8 Gene

Also Known as ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3394

About IRF8

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:85,899,162-85,922,609 (from NCBI)

This gene has 18 transcripts (splice variants), 222 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 108.4), spleen (RPKM 67.5) and 11 other tissues.

Summary

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral Infection. [provided by RefSeq, Jul 2008]

IRF8 Products (3)

mRNA	Protein	Name
NM_001363907.1	NP_001350836.1	interferon regulatory factor 8 isoform 1
NM_001363908.1	NP_001350837.1	interferon regulatory factor 8 isoform 3
NM_002163.4	NP_002154.1	interferon regulatory factor 8 isoform 2

IRF8 Protein Structure

IRF

IRF-3

0
100
200
300
400
426 a.a.

Protein Preferred Names	Protein Names
interferon regulatory factor 8	interferon consensus sequence binding protein 1

IRF8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IRF8	Q02556	IRF6	Homo sapiens	O14896	Anti Tag CoIP	21903422
Intra	IRF8	Q02556	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	IRF8	Q02556	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	IRF8	Q02556	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

IRF8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810293	IRF8 Antibody (YA9636)	WB, ICC/IF, IP, FC	Human, Mouse
HY-P83376	IRF8 Antibody (YA3121)	WB, IHC-P, IP	Human
HY-P83376A	IRF8 Antibody (YA3121)(PBS only)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Immunodeficiency 32a	Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency IMD32A Immunodeficiency 32a, Mycobacteriosis, Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Regulatory Factor 8 Deficiency Msmd Due To Partial Interferon Regulatory Factor 8 Deficiency Msmd Due To Partial Irf8 Deficiency Irf8 Deficiency, Autosomal Dominant Cd11c-Positive/Cd1c-Positive Dendritic Cell Deficiency, Autosomal Dominant Autosomal Dominant Cd11c-Positive/Cd1c-Positive Dendritic Cell Deficiency Autosomal Dominant Immunodeficiency 32a, Mycobacteriosis Autosomal Dominant Irf8 Deficiency Immunodeficiency, Type 32a
Immunodeficiency 32b	IMD32B Immunodeficiency 32b, Monocyte And Dendritic Cell Deficiency, Autosomal Recessive Immunodeficiency 32b, Monocyte, Dendritic Cell, And Natural Killer Cell Deficiency, Autosomal Recessive Irf8 Deficiency, Autosomal Recessive Epstein-Barr Virus Chronic Infection By Epstein-Barr Virus, Susceptibility To Chronic Infection By Autosomal Recessive Irf8 Deficiency Chronic Epstein-Barr Virus Infection Syndrome Caebv Syndrome Chronic Ebv Infection Syndrome Autosomal Recessive Monocyte And Dendritic Cell Deficiency Immunodeficiency, Type 32b Monocyte And Dendritic Cell Deficiency, Autosomal Recessive
Dendritic Cell Deficiency
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Monocyte, Dendritic Cell, And Nk Cell Deficiency
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Immunodeficiency 21	Monocytopenia And Mycobacterial Infection Syndrome Monomac Gata2 Deficiency Monocytopenia With Susceptibility To Infections Dcml IMD21 Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections Monocyte - B - Natural Killer - Dendritic Cell Deficiency Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Immunodeficiency 31b	IMD31B Immunodeficiency 31b, Mycobacterial And Viral Infections, Autosomal Recessive Autosomal Recessive Stat1 Deficiency Predisposition To Severe Viral Infection Due To Stat1 Deficiency Susceptibility To Viral And Mycobacterial Infections Due To Stat1 Deficiency Stat1 Deficiency, Autosomal Recessive Autosomal Recessive Immunodeficiency 31b, Mycobacterial And Viral Infections Stat1 Deficiency Autosomal Recessive Susceptibility To Mycobacterial And Viral Infections Mycobacterial And Viral Infections Due To Complete Stat1 Deficiency Immunodeficiency, Type 31b, Mycobacterial And Viral Infections, Autosomal Recessive
Axillary Adenitis	Axillary Lymphadenitis
Tuberculous Salpingitis
Immunodeficiency 55	Combined Immunodeficiency Due To Gins1 Deficiency IMD55 Cid Due To Gins1 Deficiency Combined Immunodeficiency With Intrauterine Growth Retardation-Nk Cell Deficiency-Neutropenia Combined Immunodeficiency With Intrauterine Growth Retardation-Natural Killer Cell Deficiency-Neutropenia
Gastrointestinal Tularemia	Enteric Tularemia Intestinal Tularaemia
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1	Hereditary Diffuse Leukoencephalopathy With Spheroids Adult-Onset Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Alsp Gpsc Subcortical Gliosis Of Neumann Leukoencephalopathy, Diffuse Hereditary, With Spheroids 1 Autosomal Dominant Leukoencephalopathy With Neuroaxonal Spheroids Hdls HDLS1 Leukoencephalopathy, Adult-Onset, With Axonal Spheroids And Pigmented Glia Gliosis, Familial Progressive Subcortical Leukoencephalopathy, Diffuse Hereditary, With Spheroids Pold Pigmentary Orthochromatic Leukodystrophy Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids And Pigmented Glia Familial Progressive Subcortical Gliosis Leukoencephalopathy With Neuroaxonal Spheroids, Autosomal Dominant Dementia, Familial, Neumann Type Adult-Onset Leukodystrophy With Neuroaxonal Spheroids Hereditary Diffuse Leukoencephalopathy With Axonal Spheroids Neuroaxonal Leukodystrophy Fpsg Familial Dementia, Neumann Type Familial Dementia Neumann Type Leukoencephalopathy, Diffuse Hereditary, With Spheroid
Pitt-Hopkins Syndrome	PTHS Encephalopathy, Severe Epileptic, With Autonomic Dysfunction Mental Retardation, Syndromal, With Intermittent Hyperventilation Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea Pitt Hopkins Syndrome Phs Encephalopathy Severe Epileptic With Autonomic Dysfunction
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175759	EN1033		99.96%	Unkown
HY-RS06912	IRF8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18767	Irf8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25255	Irf8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IRF8	VGNC	VGNC:30279
Mus musculus	IRF8	MGD	MGI:96395
Canis familiaris	IRF8	VGNC	VGNC:42096
Rattus norvegicus	IRF8	RGD	RGD:1312024
Macaca mulatta	IRF8	VGNC	VGNC:73698