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KCNK1 - potassium two pore domain channel subfamily K member 1 Gene

Also Known as DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3775

About KCNK1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:233,614,106-233,672,514 (from NCBI)

This gene has 6 transcripts (splice variants), 234 orthologues and 14 paralogues. Broad expression in brain (RPKM 19.7), stomach (RPKM 14.9) and 18 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require Other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

KCNK1 Products (1)

mRNA	Protein	Name
NM_002245.4	NP_002236.1	potassium channel subfamily K member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	20498050	GOA
enables potassium channel activity	IDA IDA: Inferred from direct assay	22282804	GOA
enables potassium ion leak channel activity	IDA IDA: Inferred from direct assay	21653227	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20498050	GOA
enables sodium channel activity	IDA IDA: Inferred from direct assay	21653227	GOA
NOT enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	21653227	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	21653227	GOA
involved in regulation of resting membrane potential	IMP IMP: Inferred from mutant phenotype	21653227	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	21653227	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	22282804	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21653227	GOA
part of potassium channel complex	IDA IDA: Inferred from direct assay	22282804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNK1 Protein Structure

Ion_trans_2

0
100
200
300
336 a.a.

Protein Preferred Names	Protein Names
potassium channel subfamily K member 1	inward rectifying potassium channel protein TWIK-1

KCNK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNK1	O00180	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	KCNK1	O00180	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	CDIPT	Homo sapiens	O14735	Y2H Array	32296183
Intra	KCNK1	O00180	CDIPT	Homo sapiens	O14735	Validated Y2H	32296183
Intra	KCNK1	O00180	KCNK1	Homo sapiens	O00180	FRET	20498050
Intra	KCNK1	O00180	386682	Homo sapiens	EBI-10171679	Validated Y2H	25416956
Intra	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	386682	Homo sapiens	EBI-10171679	Y2H Array	25416956
Intra	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	KCNK1	O00180	KCNK1	Homo sapiens	O00180	X-Ray Diffraction	22282804
Intra	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	KCNK1	O00180	SUMO1	Homo sapiens	P63165	Pull Down	20498050
Intra	KCNK1	O00180	SUMO1	Homo sapiens	P63165	FRET	20498050
Intra	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

KCNK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83784	KCNK1 Antibody (YA3481)	IHC-P, FC, ELISA	Human
HY-P83784A	KCNK1 Antibody (YA3481)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 8	Congenital Myasthenic Syndrome 8 CMS8 Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects Cmsppd Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects Congenital Myasthenic Syndrome Due To Agrin Deficiency Myasthenic Syndrome, Congenital, Due To Agrin Deficiency Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects
Hypokalemia	Potassium Deficiency Potassium Deficiency Disorder Hypopotassemia Potassium Potassium [K] Deficiency Hypokalaemic Syndrome Hypopotassaemia Hypopotassaemia Syndrome Hypokalaemic Potassium Depletion
Birk-Barel Syndrome	Birk-Barel Mental Retardation Dysmorphism Syndrome BIBARS Mental Retardation With Hypotonia And Facial Dysmorphism Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome Kcnk9 Imprinting Syndrome
Myasthenic Syndrome, Congenital, 10	Congenital Myasthenic Syndrome 10 CMS10 Lgm Myasthenia, Limb-Girdle, Familial Myasthenia, Limb-Girdle, Familial, Formerly Lgm, Formerly Congenital Myasthenic Syndrome Type Ib, Formerly Cms1b, Formerly Cms Ib, Formerly Myasthenic Myopathy, Formerly Familial Limb-Girdle Myasthenia Cms1b Cms Ib Congenital Myasthenic Syndrome Type 1b Congenital Myasthenic Syndrome Type Ib Myasthenic Myopathy Myasthenic Syndrome, Congenital, Type 10 Congenital Myasthenic Syndrome Ib Myopathy In Myasthenia Gravis
Progressive Familial Heart Block	Hereditary Bundle Branch Defect Hereditary Bundle Branch System Defect Familial Lenegre Disease Familial Lev Disease Familial Lev-Lenegre Disease Familial Pccd Familial Progressive Heart Block Pfhb Bundle Branch Block Hbbd Lenegre Lev Disease Lev Syndrome Lev'S Disease Lev-Lenègre Disease Pccd Progressive Cardiac Conduction Defect Bundle-Branch Block
Brain Glioblastoma Multiforme	Brain Glioblastoma Glioblastoma Multiforme Of Brain Glioblastoma Nos
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07152	KCNK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21612	Kcnk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28130	Kcnk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KCNK1	MGD	MGI:109322
Bos taurus	KCNK1	VGNC	VGNC:30465
Rattus norvegicus	KCNK1	RGD	RGD:621447
Macaca mulatta	KCNK1	VGNC	VGNC:73993
Canis familiaris	KCNK1	VGNC	VGNC:51902