LECT2 - leukocyte cell derived chemotaxin 2 Gene

Also Known as chm2; chm-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3950

About LECT2

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:135,946,904-135,954,983 (from NCBI)

This gene has 5 transcripts (splice variants) and 213 orthologues. Restricted expression toward liver (RPKM 110.6).

Summary

This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]

LECT2 Products (1)

mRNA	Protein	Name
NM_002302.3	NP_002293.2	leukocyte cell-derived chemotaxin-2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23352894	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27334921	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LECT2 Protein Structure

Peptidase_M23

0
100
151 a.a.

Protein Preferred Names	Protein Names
leukocyte cell-derived chemotaxin-2	chondromodulin-II

LECT2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LECT2	O14960	WDR26	Homo sapiens	Q9H7D7	Anti Tag CoIP	33961781
Intra	LECT2	O14960	ITIH2	Homo sapiens	P19823	Anti Tag CoIP	33961781
Intra	LECT2	O14960	LRP2	Homo sapiens	P98164	Anti Tag CoIP	33961781
Intra	LECT2	O14960	GID4	Homo sapiens	Q8IVV7	Anti Tag CoIP	33961781
Intra	LECT2	O14960	LECT2	Homo sapiens	O14960	Comigration in Gel	23352894
Intra	LECT2	O14960	RNF123	Homo sapiens	Q5XPI4	Anti Tag CoIP	33961781
Intra	LECT2	O14960	GID8	Homo sapiens	Q9NWU2	Anti Tag CoIP	33961781
Intra	LECT2	O14960	THUMPD3	Homo sapiens	Q9BV44	Anti Tag CoIP	33961781
Intra	LECT2	O14960	UBAC1	Homo sapiens	Q9BSL1	Anti Tag CoIP	33961781
Intra	LECT2	O14960	RANBP10	Homo sapiens	Q6VN20	Anti Tag CoIP	33961781
Intra	LECT2	O14960	ARMC8	Homo sapiens	Q8IUR7	Anti Tag CoIP	33961781
Intra	LECT2	O14960	NPM1	Homo sapiens	P06748	Crosslink	30021884
Intra	LECT2	O14960	RANBP9	Homo sapiens	Q96S59	Anti Tag CoIP	33961781
Intra	LECT2	O14960	CSPG4	Homo sapiens	Q6UVK1	Anti Tag CoIP	33961781
Intra	LECT2	O14960	AKAP11	Homo sapiens	Q9UKA4	Anti Tag CoIP	33961781
Intra	LECT2	O14960	KIAA0232	Homo sapiens	Q92628	Anti Tag CoIP	33961781
Intra	LECT2	O14960	FREM2	Homo sapiens	Q5SZK8	Anti Tag CoIP	33961781
Intra	LECT2	O14960	MKLN1	Homo sapiens	Q9UL63	Anti Tag CoIP	33961781
Intra	LECT2	O14960	RSL1D1	Homo sapiens	O76021	Crosslink	30021884
Intra	LECT2	O14960	RMND5A	Homo sapiens	Q9H871	Anti Tag CoIP	33961781
Intra	LECT2	O14960	MAEA	Homo sapiens	Q7L5Y9	Anti Tag CoIP	33961781
Intra	LECT2	O14960	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Immunoglobulin Heavy Chain Amyloidosis	Ah Amyloidosis Heavy Chain Amyloidosis Amyloidosis Derived From Immunoglobulin Heavy Chain Ig Heavy-Chain-Associated Amyloidosis
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Amyloidosis, Finnish Type	Finnish Type Amyloidosis Meretoja Syndrome Amyloidosis V Amyloidosis, Meretoja Type Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type Ii Familial Amyloidosis, Finnish Type Familial Amyloid Polyneuropathy Type Iv Amyloidosis Due To Mutant Gelsolin Agel Amyloidosis Gelsolin Amyloidosis Hereditary Gelsolin Amyloidosis Lattice Corneal Dystrophy Type Ii Finnish Gelsolin-Related Amyloidosis Kymenlaakso Syndrome Lattice Corneal Dystrophy, Gelsolin Type Hereditary Amyloidosis, Finnish Type Lattice Corneal Dystrophy Type 2 Amyloidosis 5 AMYL5 Agel Familial Amyloidosis Finnish Type Meretoja Type Amyloidosis Type Iv Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy, Type V Familial Amyloid Polyneuropathy, Type Iv
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07583	LECT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LECT2	VGNC	VGNC:30832
Macaca mulatta	LECT2	VGNC	VGNC:74250
Canis familiaris	LECT2	VGNC	VGNC:42629
Mus musculus	LECT2	MGD	MGI:1278342
Rattus norvegicus	LECT2	RGD	RGD:1305404
Felis catus	LECT2	VGNC	VGNC:68033
Others	LECT2	NCBI