RANBP10 - RAN binding protein 10 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57610

About RANBP10

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,723,070-67,806,560 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 13.1), endometrium (RPKM 6.2) and 25 other tissues.

Summary

RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

RANBP10 Products (5)

mRNA	Protein	Name
NM_001320238.2	NP_001307167.1	ran-binding protein 10 isoform 2
NM_001320239.2	NP_001307168.1	ran-binding protein 10 isoform 3
NM_001320240.2	NP_001307169.1	ran-binding protein 10 isoform 4
NM_001410883.1	NP_001397812.1	ran-binding protein 10 isoform 5
NM_020850.3	NP_065901.1	ran-binding protein 10 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20580816	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29911972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RANBP10 Protein Structure

SPRY

LisH

CLTH

0
100
200
300
400
500
620 a.a.

Protein Preferred Names	Protein Names
ran-binding protein 10

RANBP10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RANBP10	Q6VN20	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	RANBP10	Q6VN20	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	RANBP10	Q6VN20	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	RANBP10	Q6VN20	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	RANBP10	Q6VN20	IGFBP6	Homo sapiens	P24592	Y2H Prey Pooling	32296183
Intra	RANBP10	Q6VN20	IGFBP6	Homo sapiens	P24592	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Penicilliosis
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11643	RANBP10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RANBP10	VGNC	VGNC:33709
Mus musculus	RANBP10	MGD	MGI:1921584
Macaca mulatta	RANBP10	VGNC	VGNC:76563
Canis familiaris	RANBP10	VGNC	VGNC:82295
Felis catus	RANBP10	VGNC	VGNC:64487
Rattus norvegicus	RANBP10	RGD	RGD:1311587
Others	RANBP10	NCBI