AKAP11 - A-kinase anchoring protein 11 Gene

Also Known as PRKA11; AKAP-11; AKAP220; PPP1R44

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11215

About AKAP11

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:42,271,477-42,323,261 (from NCBI)

This gene has 1 transcript (splice variant), 201 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 22.2), testis (RPKM 15.0) and 24 other tissues.

Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

AKAP11 Products (1)

mRNA Protein Name
NM_016248.4 NP_057332.1 A-kinase anchor protein 11

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27484798 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 11

  • A kinase (PRKA) anchor protein 11

AKAP11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKAP11 Q9UKA4 LITAF Homo sapiens Q99732
Y2H Pooling
32814053
Intra
AKAP11 Q9UKA4 LITAF Homo sapiens Q99732
Validated Y2H
32814053
Intra
AKAP11 Q9UKA4 LITAF Homo sapiens Q99732
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 48

  • RP48

  • Retinitis Pigmentosa, Type 48
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00514 AKAP11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AKAP11 VGNC VGNC:37753
Mus musculus AKAP11 MGD MGI:2684060
Bos taurus AKAP11 VGNC VGNC:25781
Felis catus AKAP11 VGNC VGNC:59712
Macaca mulatta AKAP11 VGNC VGNC:69765
Rattus norvegicus AKAP11 RGD RGD:2079
Others AKAP11 NCBI