MGAT5 - alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Gene

Also Known as GNT-V; GNT-VA; MGAT5A; glcNAc-T V

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4249

About MGAT5

Cytogenetic location: 2q21.2-q21.3 Genomic coordinates (GRCh38): 2:134,119,935-134,454,621 (from NCBI)

This gene has 5 transcripts (splice variants), 130 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 14.6), lymph node (RPKM 12.4) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the Glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important Enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

MGAT5 Products (2)

mRNA Protein Name
NM_001371457.1 NP_001358386.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
NM_002410.5 NP_002401.1 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
10395745 GOA
enables manganese ion binding IDA
IDA: Inferred from direct assay
10395745 GOA
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
24846175 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
24846175 GOA
involved in positive regulation of receptor signaling pathway via STAT IDA
IDA: Inferred from direct assay
24846175 GOA
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
24846175 GOA
involved in protein N-linked glycosylation via asparagine IDA
IDA: Inferred from direct assay
10395745 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
10395745 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGAT5 Protein Structure

DUF4525

DUF4525: Domain of unknown function (DUF4525) (4 - 139)

Glyco_transf_18

Glyco_transf_18: Glycosyltransferase family 18 (172 - 726)

  • 0
  • 200
  • 400
  • 600
  • 741 a.a.
Protein Preferred Names Protein Names

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

  • N-acetylglucosaminyl-transferase V

Recombinant MGAT5 Proteins

Cat. No. Product Name Accession Purity
HY-P75927 MGAT5 Protein, Human (HEK293, His) Q09328 (L189-L741) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Congenital Disorder Of Glycosylation, Type Iia

  • CDG2A

  • Congenital Disorder Of Glycosylation Type Iia

  • Cdg Iia

  • Cdgiia

  • Congenital Disorder Of Glycosylation Type 2a

  • Alkuraya Syndrome

  • Mental Retardation, Growth Retardation, Prominent Columella, And Open Mouth

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii

  • Mgat2-Cdg

  • Cdg-Iia

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii, Formerly

  • Cdgs2, Formerly

  • Cdgs2

  • Cdg Syndrome Type Iia

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iia

  • N-Acetylglucosaminyltransferase 2 Deficiency

  • Congenital Disorder Of Glycosylation 2a

  • Carbohydrate-Deficient Glycoprotein Syndrome Type Ii

  • Cdgs Type Ii

  • Carbohydrate-Deficient Glycoprotein Syndrome Type 2

  • Glycosylation, Congenital Disorder Of, Type Iia
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Walker-Warburg Syndrome

  • Hard Syndrome

  • Walker-Warburg Congenital Muscular Dystrophy

  • Cerebroocular Dysplasia-Muscular Dystrophy Syndrome

  • Cod-Md Syndrome

  • Chemke Syndrome

  • Hydrocephalus, Agyria And Retinal Dysplasia

  • Cerebroocular Dysgenesis

  • Cerebroocular Dysplasia Muscular Dystrophy Syndrome

  • Hard +/- E Syndrome

  • Pagon Syndrome

  • Warburg Syndrome

  • Hydrocephalus, Agyria, And Retinal Dysplasia

  • Mddga

  • Muscular Dystrophy-Dystroglycanopathy , Type A

  • Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A

  • Hydrocephalus-Agyria-Retinal Dysplasia Syndrome

  • Wws

  • Dystrophy, Muscular, Dystroglycanopathy, Type A
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163121 PST3.1a Inhibitor / Unkown
HY-RS08407 MGAT5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08408 MGAT5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18828 Mgat5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25319 Mgat5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MGAT5 VGNC VGNC:74716
Mus musculus MGAT5 MGD MGI:894701
Rattus norvegicus MGAT5 RGD RGD:620100
Bos taurus MGAT5 VGNC VGNC:54620
Felis catus MGAT5 VGNC VGNC:68249
Canis familiaris MGAT5 VGNC VGNC:54809
Others MGAT5 NCBI