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NDUFB10 - NADH:ubiquinone oxidoreductase subunit B10 Gene

Also Known as PDSW; MC1DN35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4716

About NDUFB10

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,959,538-1,961,975 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 91.0), kidney (RPKM 64.3) and 25 other tissues.

Summary

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of mitochondrial respiratory chain complex I. Implicated in nuclear type mitochondrial complex I deficiency 35. [provided by Alliance of Genome Resources, Apr 2022]

NDUFB10 Products (1)

mRNA	Protein	Name
NM_004548.3	NP_004539.1	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14557246	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	27626371	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
located in mitochondrial inner membrane	IMP IMP: Inferred from mutant phenotype	28040730	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB10 Protein Structure

NDUFB10

0
100
172 a.a.

Protein Preferred Names	Protein Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	CI-PDSW

NDUFB10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NDUFB10	O96000	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	NDUFB10	O96000	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	NDUFB10	O96000	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
Intra	NDUFB10	O96000	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
Intra	NDUFB10	O96000	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
Intra	NDUFB10	O96000	SSB	Homo sapiens	P05455	Y2H Pooling	32814053
Intra	NDUFB10	O96000	SSB	Homo sapiens	P05455	Validated Y2H	32814053
Intra	NDUFB10	O96000	SSB	Homo sapiens	P05455	Y2H Array	32814053
Intra	NDUFB10	O96000	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	NDUFB10	O96000	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	NDUFB10	O96000	HTT	Homo sapiens	P42858	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

NDUFB10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81585	NDUFB10 Antibody (YA1330)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P81585A	NDUFB10 Antibody (YA1330)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mitochondrial Complex I Deficiency, Nuclear Type 35	MC1DN35 Mitochondrial Complex 1 Deficiency, Nuclear Type 35 Nuclear Type Mitochondrial Complex I Deficiency 35
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Mitochondrial Dna Depletion Syndrome 9	MTDPS9 Fatal Infantile Lactic Acidosis Lactic Acidosis, Fatal Infantile, Formerly Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome, Type 9 Lactic Acidosis, Fatal Infantile
Nuclear Type Mitochondrial Complex I Deficiency	Mc1dn Mitochondrial Complex I Deficiency, Nuclear Type Mitochondrial Complex I Deficiency, Nuclear
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Leukodystrophy	Leukodystrophies
Myopathy	Muscular Diseases Myopathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09145	NDUFB10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NDUFB10	VGNC	VGNC:82556
Mus musculus	NDUFB10	MGD	MGI:1915592
Canis familiaris	NDUFB10	VGNC	VGNC:43699
Rattus norvegicus	NDUFB10	RGD	RGD:1310782
Macaca mulatta	NDUFB10	VGNC	VGNC:75155
Bos taurus	NDUFB10	VGNC	VGNC:31960
Others	NDUFB10	NCBI