POU3F2 - POU class 3 homeobox 2 Gene

Also Known as BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5454

About POU3F2

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:98,834,574-98,839,458 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 17 paralogues.

Summary

This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

POU3F2 Products (1)

mRNA	Protein	Name
NM_005604.4	NP_005595.2	POU domain, class 3, transcription factor 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11029584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11029584	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15024079	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU3F2 Protein Structure

Pou

Homeobox

0
100
200
300
400
443 a.a.

Protein Preferred Names	Protein Names
POU domain, class 3, transcription factor 2	brain-2

POU3F2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POU3F2	P20265	EP300	Homo sapiens	Q09472	Y2H	11029584
Intra	POU3F2	P20265	POU3F2	Homo sapiens	P20265	Pull Down	11029584
Intra	POU3F2	P20265	POU3F2	Homo sapiens	P20265	Y2H	11029584
Intra	POU3F2	P20265	SOX10	Homo sapiens	P56693	Pull Down	11029584
Intra	POU3F2	P20265	EP300	Homo sapiens	Q09472	Pull Down	11029584
Intra	POU3F2	P20265	GTF2B	Homo sapiens	Q00403	Pull Down	11029584

Cross: Cross-species interaction Intra: Intraspecies interaction

POU3F2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84168	POU3F2 Antibody (YA3865)	WB, ELISA	Human
HY-P84168A	POU3F2 Antibody (YA3865)(PBS only)	WB, ELISA	Human

Related Diseases

Diseases	Alias
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Microphthalmia, Syndromic 3	MCOPS3 Aeg Syndrome Microphthalmia And Esophageal Atresia Syndrome Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome Anophthalmia-Esophageal-Genital Syndrome Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System Syndromic Microphthalmia 3 Sox2 Anophthalmia Syndrome Anophthalmia Clinical With Associated Anomalies Anophthalmia Esophageal Genital Syndrome Anophthalmia Microphthalmia Esophageal Atresia Syndromic Microphthalmia Type 3 Sox2-Related Eye Disorders Anophthalmia, Clinical, With Associated Anomalies Syndromic Microphthalmia, Type 3 Microphthalmia, Syndromic, 3 Anophthalmia/Microphthalmia-Esophageal Atresia Microphthalmia Syndromic, Type 3
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10901	POU3F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174478	Mouse Pou3f2 mRNA		/	Unkown
HY-174545	Human POU3F2 mRNA		/	Unkown
HY-RS21172	Pou3f2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27689	Pou3f2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	POU3F2	VGNC	VGNC:106871
Rattus norvegicus	POU3F2	RGD	RGD:61946
Canis familiaris	POU3F2	VGNC	VGNC:57229
Macaca mulatta	POU3F2	VGNC	VGNC:99426
Mus musculus	POU3F2	MGD	MGI:101895
Others	POU3F2	NCBI