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POU3F2 Antibody (YA3865)

(Synonyms: BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3)

POU3F2 Antibody (YA3865) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to POU3F2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS with 0.05% sodium azide

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:250 1:10000

Product Details

Description

POU3F2 Antibody (YA3865) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to POU3F2.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 47 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 47 kDa
Immunogen

Purified recombinant fragment of human POU3F2 (AA: 214-362) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS with 0.05% sodium azide

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    POU3F2 transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes

  • Subcellular Localization

    Nucleus

  • Expression


    Tissue_specificity:Specifically expressed in neuroectodermal cell lineages

  • Subunit

    Interacts with PQBP1 (PubMed:10332029). Interaction with ISL1 (By similarity)

  • SwissProt ID

    P20265

  • Gene ID
    5454 [NCBI]
  • Synonyms

    BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3

POU3F2 Antibody (YA3865) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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