YEATS2 - YEATS domain containing 2 Gene

Also Known as FAME4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55689

About YEATS2

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:183,697,797-183,812,624 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 7.4), brain (RPKM 7.1) and 25 other tissues.

Summary

Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

YEATS2 Products (4)

mRNA	Protein	Name
NM_001351369.2	NP_001338298.1	YEATS domain-containing protein 2 isoform 3
NM_001351370.2	NP_001338299.1	YEATS domain-containing protein 2 isoform 1
NM_001351371.2	NP_001338300.1	YEATS domain-containing protein 2 isoform 2
NM_018023.5	NP_060493.3	YEATS domain-containing protein 2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	18838386	GOA
enables histone binding	IDA IDA: Inferred from direct assay	27103431	GOA
enables histone reader activity	IDA IDA: Inferred from direct assay	27103431	GOA
enables modification-dependent protein binding	IDA IDA: Inferred from direct assay	27103431	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18838386	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18838386	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18838386	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19936620	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	19103755	GOA
involved in regulation of cell division	IDA IDA: Inferred from direct assay	20562830	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22055187	GOA
involved in regulation of tubulin deacetylation	IMP IMP: Inferred from mutant phenotype	20562830	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ATAC complex	IDA IDA: Inferred from direct assay	18838386	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YEATS2 Protein Structure

YEATS

0
300
600
900
1200
1422 a.a.

Protein Preferred Names	Protein Names
YEATS domain-containing protein 2

YEATS2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811168	YEATS2 Antibody	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Epilepsy, Familial Adult Myoclonic, 4	FAME4 Fcmte4 Cortical Myoclonic Tremor With Epilepsy, Familial, 4 Familial Adult Myoclonic Epilepsy 4 Epilepsy, Myoclonic, Familial Adult, 4 Familial Cortical Myoclonic Tremor And Epilepsy 4 Epilepsy, Myoclonic, Familial Adult, Type 4
Familial Adult Myoclonic Epilepsy	Benign Adult Familial Myoclonus Epilepsy Bafme Benign Adult Familial Myoclonic Epilepsy Fame Familial Cortical Myoclonic Tremor And Epilepsy Fcmte Adcme Autosomal Dominant Cortical Myoclonus And Epilepsy Fam Epilepsy, Myoclonic, Familial Adult Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Epilepsy, Familial Adult Myoclonic, 7	FAME7 Bafme7 Fcmte7 Benign Adult Familial Myoclonic Epilepsy 7 Cortical Myoclonic Tremor With Epilepsy, Familial, 7 Familial Adult Myoclonic Epilepsy 7 Familial Cortical Myoclonic Tremor And Epilepsy 7 Benign Adult Familial Myoclonic Epilepsy 27 Epilepsy, Myoclonic, Familial Adult, Type 7
Epilepsy, Familial Adult Myoclonic, 1	FAME1 Benign Adult Familial Myoclonic Epilepsy 1 Bafme1 Fcmte1 Cortical Myoclonic Tremor With Epilepsy, Familial, 1 Familial Adult Myoclonic Epilepsy 1 Familial Cortical Myoclonic Tremor And Epilepsy 1 Epilepsy, Myoclonic, Familial Adult, Type 1
Epilepsy, Familial Adult Myoclonic, 3	FAME3 Fcmte3 Cortical Myoclonic Tremor With Epilepsy, Familial, 3 Familial Adult Myoclonic Epilepsy 3 Familial Cortical Myoclonic Tremor And Epilepsy 3 Epilepsy, Myoclonic, Familial Adult, Type 3
Epilepsy, Familial Adult Myoclonic, 2	FAME2 Benign Adult Familial Myoclonic Epilepsy 2 Bafme2 Fcmte2 Adcme Cortical Myoclonic Tremor With Epilepsy, Familial, 2 Cortical Myoclonus And Epilepsy, Autosomal Dominant Familial Adult Myoclonic Epilepsy 2 Epilepsy, Myoclonic, Benign Adult Familial, Type 2 Autosomal Dominant Cortical Myoclonus And Epilepsy Familial Cortical Myoclonic Tremor And Epilepsy 2 Epilepsy, Myoclonic, Familial Adult, Type 2
Epilepsy, Familial Adult Myoclonic, 6	FAME6 Benign Adult Familial Myoclonic Epilepsy 6 Bafme6 Fcmte6 Cortical Myoclonic Tremor With Epilepsy, Familial, 6 Familial Adult Myoclonic Epilepsy 6 Familial Cortical Myoclonic Tremor And Epilepsy 6 Epilepsy, Myoclonic, Familial Adult, Type 6
Macular Dystrophy, Patterned, 3	Martinique Crinkled Retinal Pigment Epitheliopathy Patterned Macular Dystrophy 3 MDPT3 Mcrpe
Periosteal Chondrosarcoma	Juxtacortical Chondrosarcoma
Mild Cognitive Impairment
Adolescence-Adult Electroclinical Syndrome
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Spondyloepiphyseal Dysplasia Congenita	SEDC Sed Congenita Spondyloepiphyseal Dysplasia, Congenital Type Late Spondyloepiphyseal Dysplasia Sed, Congenital Type Congenital Spondyloepiphyseal Dysplasia Spranger-Wiedemann Disease Spondyloepiphyseal Dysplasia Congenital Type Dysplasia, Spondyloepiphyseal, Congenita Spondyloepiphyseal Dysplasia, Congenita Spondyloepiphyseal Dysplasia Tarda, X-Linked
Heinz Body Anemias	Heinz Body Anemia Heinz Body Anemias, Alpha- HEIBAN Anemia, Heinz Body Acquired Heinz Body Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W105310A	Croconic acid disodium		99.98%	Unkown
HY-162350	TDI-11055		98.18%	Unkown
HY-155412	PFI-6		99.91%	Unkown
HY-181065	LS-170	Inhibitor	/	Unkown
HY-183825	Eleven-Nineteen-Leukemia Protein IN-4	Inhibitor	/	Unkown
HY-RS15920	YEATS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176821	PFI-6N		/	Unkown
HY-RS21976	Yeats2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28493	Yeats2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	YEATS2	VGNC	VGNC:48482
Macaca mulatta	YEATS2	VGNC	VGNC:79502
Mus musculus	YEATS2	MGD	MGI:2447762
Rattus norvegicus	YEATS2	RGD	RGD:1566176
Felis catus	YEATS2	VGNC	VGNC:67134
Bos taurus	YEATS2	VGNC	VGNC:37020