Eleven-Nineteen-Leukemia Protein IN-4
Eleven-Nineteen-Leukemia Protein IN-4 is a ENL YEATS domain inhibitor with an IC50 of 62.0 nM and a Kd of 100.4 nM. Eleven-Nineteen-Leukemia Protein IN-4 downregulates MYC expression and inhibits cancer cell growth; it exerts a synergistic effect with the bromodomain inhibitor JQ-1 (HY-13030). Eleven-Nineteen-Leukemia Protein IN-4 can be used in the research of acute myeloid leukemia.
For research use only. We do not sell to patients.
- Formula: C26H38N4O4Se2
- Molecular Weight:628.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Eleven-Nineteen-Leukemia Protein IN-4 (Compound DC_E35_5d) (72 h) inhibits the viability of MOLM-13 cells (IC50 = 2.5 μM) and MV-4-11 cells (IC50 = 1.9 μM) in a dose-dependent manner[1].
Eleven-Nineteen-Leukemia Protein IN-4 (1 μM; 6 h) reduces the thermal stability of endogenous ENL protein in MOLM-13 cells, but has no effect on GAS41 or YEATS2, confirming its selective target-binding activity[1].
Eleven-Nineteen-Leukemia Protein IN-4 (1 μM; 72 h) reduces the MYC mRNA expression level in MOLM-13 cells by approximately 60% following 72 h of treatment[1].
Eleven-Nineteen-Leukemia Protein IN-4 (0-5000 nM; 72 h) synergizes with JQ-1 to downregulate MYC expression and inhibit the proliferation of MOLM-13 cells, with HSA and Loewe synergy scores of 11.103 and 27.230, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13 acute myeloid leukemia cells
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Concentration:1 μM
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Incubation Time:72 h
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Result:Suppressed MYC mRNA expression by approximately 60% compared to DMSO-treated controls.
Chemical Information
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Molecular Weight 628.52
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Formula C26H38N4O4Se2
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SMILES
C[C@H](OCC1=CC=CC=C1)[C@@H](N)C(NCC[Se][Se]CCNC([C@H](N)[C@@H](OCC2=CC=CC=C2)C)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. 新参考文献 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Eleven-Nineteen-Leukemia Protein IN-4 Related Classifications
HY-183825 Related Classifications
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