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56146

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By Targets:	Apoptosis (3) Autophagy (1) c-Met/HGFR (1) FLT3 (1) Furin (1) HIV (1) MicroRNA (8) MMP (1) Notch (1) PAI-1 (1) PKC (1) RABV (1) Ser/Thr Protease (1)
By Research Areas:	Cancer (12) Infection (1) Inflammation/Immunology (1)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) miRNA inhibitors (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18980

Rottlerin 20+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	PKC Autophagy Apoptosis HIV RABV	Infection Cancer
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

HY-153227

SU 5616	c-Met/HGFR	Cancer
SU 5616 is an organic compound. SU 5616 potentially modulates tyrosine kinase signal transduction, and regulates abnormal cell proliferation .

HY-18952A

(Z)-SU5614	FLT3 Apoptosis	Cancer
(Z)-SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3 .

HY-R03301

*mmu-miR-5616-5p mimic*	MicroRNA	Cancer
mmu-miR-5616-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5616-5p mimic mmu-miR-5616-5p mimic

HY-R03300

*mmu-miR-5616-3p mimic*	MicroRNA	Cancer
mmu-miR-5616-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-5616-3p mimic mmu-miR-5616-3p mimic

HY-183626

TM5614 sodium	PAI-1 Ser/Thr Protease Furin MMP Notch Apoptosis	Inflammation/Immunology Cancer
TM5614 sodium is an orally active and specific PAI-1 inhibitor with an IC₅₀ of <6.95 μM. TM5614 sodium blocks the interaction between PAI-1 and serine proteases or LRP-1, and enhances plasmin generation. TM5614 sodium restores macrophage efferocytosis and promotes macrophage polarization. TM5614 sodium alleviates PAI-1-mediated inhibition of Furin, promotes MT1-MMP maturation, activates the NOTCH1 signaling pathway, inhibits proliferation and induces apoptosis. TM5614 sodium promotes skeletal muscle regeneration and alleviates inflammation in a mouse model of skeletal muscle injury. TM5614 sodium can be used in research on skeletal muscle injury-induced inflammation and chronic myeloid leukemia .

HY-RI03300

*mmu-miR-5616-3p inhibitor*	MicroRNA	Cancer
mmu-miR-5616-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5616-3p inhibitor mmu-miR-5616-3p inhibitor

HY-RI03301A

*mmu-miR-5616-5p antagomir*	MicroRNA	Cancer
mmu-miR-5616-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5616-5p antagomir mmu-miR-5616-5p antagomir

HY-R03300A

*mmu-miR-5616-3p agomir*	MicroRNA	Cancer
mmu-miR-5616-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5616-3p agomir mmu-miR-5616-3p agomir

HY-RI03301

*mmu-miR-5616-5p inhibitor*	MicroRNA	Cancer
mmu-miR-5616-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-5616-5p inhibitor mmu-miR-5616-5p inhibitor

HY-RI03300A

*mmu-miR-5616-3p antagomir*	MicroRNA	Cancer
mmu-miR-5616-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5616-3p antagomir mmu-miR-5616-3p antagomir

HY-R03301A

*mmu-miR-5616-5p agomir*	MicroRNA	Cancer
mmu-miR-5616-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-5616-5p agomir mmu-miR-5616-5p agomir

Rottlerin 20+ Cited Publications Mallotoxin; NSC 56346; NSC 94525	Structural Classification Chalcones Flavonoids Classification of Application Fields Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Mallotus philippensis Source Classification Cancer	PKC Autophagy Apoptosis HIV RABV
Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC₅₀ values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation . Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection .

Host:	Mouse (4) Rabbit (1)
Reactivity:	Human (5) Bovine (1) Rat (3) Mouse (4) Rabbit (1) Zebrafish (1) Chicken (1) Dog (1) Pig (1)
Application:	IHC-P (4) ICC/IF (5) IP (1) WB (5) ELISA (4)
Isotype:	IgG2b,IgG/Kappa (1) IgG1 (1) IgG/Kappa (1) IgG2b (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (5)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86454

	YTHDF2 Antibody (YA6146)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	YTHDF2 Antibody (YA6146) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to YTHDF2.

HY-P85954

	Claudin 4 Antibody (YA5646)	IHC-P, WB, ICC/IF, ELISA	Human
	Claudin 4 Antibody (YA5646) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Claudin 4.

HY-P85922

	Myoglobin Antibody (YA5614) MB; MGC13548; MYG_HUMAN; Myoglobin	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Myoglobin Antibody (YA5614) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Myoglobin.

HY-P85454

	PP2A alpha Antibody (YA5146) PPP2CA; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; RP-C	WB, ICC/IF	Human, Mouse, Bovine, Chicken, Dog, Pig, Rabbit, Zebrafish
	PP2A alpha Antibody (YA5146) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PP2A alpha.

HY-P85924

	p57 Kip2 Antibody (YA5616) Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57KIP2; WBS	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	p57 Kip2 Antibody (YA5616) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to p57 Kip2.

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Cat. No.	Product Name		Classification

HY-R03301

*mmu-miR-5616-5p mimic*		MicroRNAs miRNA mimics
mmu-miR-5616-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-R03300

*mmu-miR-5616-3p mimic*		MicroRNAs miRNA mimics
mmu-miR-5616-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

HY-RI03300

*mmu-miR-5616-3p inhibitor*		MicroRNAs miRNA inhibitors
mmu-miR-5616-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03301A

*mmu-miR-5616-5p antagomir*		MicroRNAs miRNA antagomirs
mmu-miR-5616-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03300A

*mmu-miR-5616-3p agomir*		MicroRNAs miRNA agomirs
mmu-miR-5616-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-RI03301

*mmu-miR-5616-5p inhibitor*		MicroRNAs miRNA inhibitors
mmu-miR-5616-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

HY-RI03300A

*mmu-miR-5616-3p antagomir*		MicroRNAs miRNA antagomirs
mmu-miR-5616-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

HY-R03301A

*mmu-miR-5616-5p agomir*		MicroRNAs miRNA agomirs
mmu-miR-5616-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

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56146

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