CAMK1D - calcium/calmodulin dependent protein kinase ID Gene

Also Known as CKLiK; CaM-K1; CaMKID

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57118

About CAMK1D

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:12,349,547-12,835,545 (from NCBI)

This gene has 3 transcripts (splice variants), 267 orthologues and 22 paralogues. Broad expression in brain (RPKM 10.9), skin (RPKM 4.6) and 21 other tissues.

Summary

This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and Apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]

CAMK1D Products (3)

mRNA Protein Name
NM_001351032.2 NP_001337961.1 calcium/calmodulin-dependent protein kinase type 1D isoform 3
NM_020397.4 NP_065130.1 calcium/calmodulin-dependent protein kinase type 1D isoform 1
NM_153498.4 NP_705718.1 calcium/calmodulin-dependent protein kinase type 1D isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium/calmodulin-dependent protein kinase activity IDA
IDA: Inferred from direct assay
11050006 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32707033 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of CREB transcription factor activity IDA
IDA: Inferred from direct assay
16324104 GOA
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
15840691 GOA
involved in positive regulation of respiratory burst IMP
IMP: Inferred from mutant phenotype
15840691 GOA
involved in regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
17056143 GOA
involved in regulation of granulocyte chemotaxis IMP
IMP: Inferred from mutant phenotype
15840691 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11050006 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16324104 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK1D Protein Structure

Pkinase

Pkinase: Protein kinase domain (23 - 279)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
Protein Preferred Names Protein Names

calcium/calmodulin-dependent protein kinase type 1D

  • CAMK1D/ANAPC5 fusion

CAMK1D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAMK1D Q8IU85 CAMK1 Homo sapiens Q14012
Pull Down
32707033
Intra
CAMK1D Q8IU85 CAMK1 Homo sapiens Q14012
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CAMK1D Proteins

Cat. No. Product Name Accession Purity
HY-P7715 CAMKI delta/CAMK1D Protein, Human (GST) Q8IU85-1 (M1-K385) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ceroid Lipofuscinosis, Neuronal, 6a

  • Neuronal Ceroid Lipofuscinosis 6

  • CLN6

  • Vlincl

  • Cln6 Disease

  • Ceroid Lipofuscinosis, Neuronal, 6

  • Late-Infantile Neuronal Ceroid Lipofuscinosis

  • CLN6A

  • Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant

  • Neuronal Ceroid Lipofuscinosis 6a

  • Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset

  • Cln6 Disease, Adult Kufs Type A

  • Cln6 Disease, Late Infantile

  • Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant

  • Ceroid Lipofuscinosis Neuronal 6

  • Cln6-Related Neuronal Ceroid Lipofuscinosis

  • Late Infantile Neuronal Ceroid Lipofuscinosis

  • Jansky-Bielschowsky Disease

  • Lincl

  • Late Infantile Ncl

  • Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset

  • Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis

  • Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant

  • Lipofuscinosis, Ceroid, Neuronal, Type 6

  • Ceroid Lipofuscinosis, Neuronal, 5
Wolfram Syndrome 1

  • WFS1

  • Didmoad

  • Wfs

  • Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

  • Wolfram Syndrome
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diabetes Mellitus

  • Diabetes
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148907 CS640 Inhibitor 99.48% Unkown
HY-148913 CS587 Inhibitor 98.18% Unkown
HY-156871 CAMK1D-IN-1 Inhibitor 99.06% Unkown
HY-RS01852 CAMK1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17384 Camk1d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23839 Camk1d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CAMK1D MGD MGI:2442190
Bos taurus CAMK1D VGNC VGNC:58595
Macaca mulatta CAMK1D VGNC VGNC:70579
Rattus norvegicus CAMK1D RGD RGD:1560691
Canis familiaris CAMK1D VGNC VGNC:38678
Felis catus CAMK1D VGNC VGNC:60329
Others CAMK1D NCBI