PTH2R - parathyroid hormone 2 receptor Gene

Homo sapiens

Also known as PTHR2

Gene ID: 5746 | Gene type: protein coding

About PTH2R

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:208,359,692-208,494,506 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 42 paralogues. Biased expression in bone marrow (RPKM 1.3), salivary gland (RPKM 0.8) and 10 other tissues.

Summary

The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

PTH2R Products(5)

mRNA	Protein	Name
NM_001309516.2	NP_001296445.1	parathyroid hormone 2 receptor isoform 2
NM_001371905.1	NP_001358834.1	parathyroid hormone 2 receptor isoform 2
NM_001371906.1	NP_001358835.1	parathyroid hormone 2 receptor isoform 2
NM_001371907.1	NP_001358836.1	parathyroid hormone 2 receptor isoform 3
NM_005048.4	NP_005039.1	parathyroid hormone 2 receptor isoform 1 precursor

PTH2R Protein Structure

HRM

7tm_2

0
100
200
300
400
500
550 a.a.

Protein Preferred Names

Protein Names

parathyroid hormone 2 receptor

PTH2 receptor

Related Diseases

Diseases

Alias

Syndromic Intellectual Disability

Chondrodysplasia, Blomstrand Type

Chondrodysplasia Blomstrand Type	BOCD
Blomstrand Lethal Chondrodysplasia	Blomstrand Lethal Osteochondrodysplasia
Blomstrand'S Lethal Chondrodysplasia	Blc
Blomstrand Chondrodysplasia	Blomstrand Osteochondrodysplasia

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Metaphyseal Chondrodysplasia, Jansen Type

Metaphyseal Chondrodysplasia, Murk Jansen Type	Jansen'S Metaphyseal Chondrodysplasia
MCDJ	Murk Jansen Type Metaphyseal Chondrodysplasia
Jansen Type Metaphyseal Chondrodysplasia	Jansen Disease
Jansen Metaphyseal Chondrodysplasia	Jansen Metaphyseal Dysostosis
Metaphyseal Chondrodysplasia Murk Jansen Type	Chondrodysplasia, Metaphyseal, Murk Jansen Type

Benign Chronic Pemphigus

Hailey-Hailey Disease	Pemphigus, Benign Familial
Familial Benign Pemphigus	Benign Familial Pemphigus
Familial Benign Chronic Pemphigus	BCPM
HHD	Benign Chronic Familial Pemphigus Of Hailey-Hailey
Pemphigus, Chronic, Benign

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1852	TIP 39, Tuberoinfundibular Neuropeptide	Activator	99.84%	Unkown
HY-RS11397	PTH2R Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PTH2R	VGNC	VGNC:33516
Canis familiaris	PTH2R	VGNC	VGNC:45156
Macaca mulatta	PTH2R	VGNC	VGNC:76592
Mus musculus	PTH2R	MGD	MGI:2180917
Rattus norvegicus	PTH2R	RGD	RGD:620612
Felis catus	PTH2R	VGNC	VGNC:69151

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