SGCG - sarcoglycan gamma Gene
Also Known as A4; MAM; DMDA; SCG3; 35DAG; DAGA4; DMDA1; LGMD2C; LGMDR5; SCARMD2; gamma-SG
Species: Homo sapiens
About SGCG
This gene has 1 transcript (splice variant), 214 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in heart (RPKM 31.0), fat (RPKM 8.6) and 2 other tissues.
Summary
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with Dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of Dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal Cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
SGCG Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_000231.3 | NP_000222.2 | gamma-sarcoglycan isoform 1 |
| NM_001378244.1 | NP_001365173.1 | gamma-sarcoglycan isoform 2 |
| NM_001378245.1 | NP_001365174.1 | gamma-sarcoglycan isoform 1 |
| NM_001378246.1 | NP_001365175.1 | gamma-sarcoglycan isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
23414517 | GOA |
SGCG Protein Structure
Sarcoglycan_1: Sarcoglycan complex subunit protein (23 - 284)
- 0
- 100
- 200
- 291 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
gamma-sarcoglycan |
|
SGCG Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SGCG | Q13326 | SPACA1 | Homo sapiens | Q9HBV2 | 32296183 | |
|
Intra
|
SGCG | Q13326 | SPACA1 | Homo sapiens | Q9HBV2 | 32296183 | |
|
Intra
|
SGCG | Q13326 | SPACA1 | Homo sapiens | Q9HBV2 | 32296183 | |
|
Intra
|
SGCG | Q13326 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
SGCG | Q13326 | CLDN5 | Homo sapiens | O00501 | 32296183 | |
|
Intra
|
SGCG | Q13326 | DYSF | Homo sapiens | O75923 | 23414517 |
SGCG Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P87159 | gamma Sarcoglycan Antibody (YA6852) | WB, IP, IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 5 |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy |
|
|
| Limb-Girdle Muscular Dystrophy |
|
|
| Muscular Dystrophy |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2c |
|
|
| Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 6 |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2f |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2d |
|
|
| Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2 |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2a |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2g |
|
|
| Miyoshi Muscular Dystrophy |
|
|
| Myopathy |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2j |
|
|
| Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2 |
|
|
| Combined Oxidative Phosphorylation Deficiency 31 |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2l |
|
|
| Muscular Dystrophy, Becker Type |
|
|
| Muscular Dystrophy-Dystroglycanopathy , Type C, 5 |
|
|
| Cardiomyopathy, Dilated, 1g |
|
|
| Muscular Dystrophy-Dystroglycanopathy , Type C, 1 |
|
|
| Arrhythmogenic Right Ventricular Cardiomyopathy |
|
|
| Muscular Dystrophy, Congenital Merosin-Deficient, 1a |
|
|
| Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2h |
|
|
| Facioscapulohumeral Muscular Dystrophy 1 |
|
|
| Cardiomyopathy, Dilated, 3b |
|
|
| Ullrich Congenital Muscular Dystrophy 1 |
|
|
| Miyoshi Muscular Dystrophy 3 |
|
|
| Muscle Tissue Disease |
|
|
| Myopathy With Extrapyramidal Signs |
|
|
| Muscular Disease |
|
|
| Tibial Muscular Dystrophy |
|
|
| Bethlem Myopathy 1 |
|
|
| Emery-Dreifuss Muscular Dystrophy |
|
|
| Myofibrillar Myopathy |
|
|
| Walker-Warburg Syndrome |
|
|
| Isolated Elevated Serum Creatine Phosphokinase Levels |
|
|
| Congenital Myasthenic Syndrome |
|
|
| Neuromuscular Disease |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | SGCG | VGNC | VGNC:46095 |
| Macaca mulatta | SGCG | VGNC | VGNC:77194 |
| Rattus norvegicus | SGCG | RGD | RGD:1359577 |
| Felis catus | SGCG | VGNC | VGNC:102316 |
| Bos taurus | SGCG | VGNC | VGNC:34539 |
| Mus musculus | SGCG | MGD | MGI:1346524 |
| Others | SGCG | NCBI |