BMP5 - bone morphogenetic protein 5 Gene

Homo sapiens

Gene ID: 653 | Gene type: protein coding

About BMP5

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,753,653-55,875,590 (from NCBI)

This gene has 1 transcript (splice variant), 197 orthologues, 31 paralogues and is associated with 70 phenotypes. Biased expression in placenta (RPKM 11.7), lung (RPKM 3.1) and 7 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]

BMP5 Products(3)

mRNA	Protein	Name
NM_001329754.2	NP_001316683.1	bone morphogenetic protein 5 isoform 2 precursor
NM_001329756.2	NP_001316685.1	bone morphogenetic protein 5 isoform 3 precursor
NM_021073.4	NP_066551.1	bone morphogenetic protein 5 isoform 1 preproprotein

BMP5 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
454 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein 5

Recombinant BMP5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75472	BMP-5 Protein, Human (HEK293, hFc)	NP_066551.1 (Q324-H454)	≥95%
HY-P700028AF	Animal-Free BMP-5 Protein, Human (His)	P22003 (A317-H454)	≥95%

Related Diseases

Diseases

Alias

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Cardiomyopathy, Familial Restrictive, 3

RCM3	Restrictive Cardiomyopathy 3
Familial Restrictive Cardiomyopathy 3	Cardiomyopathy, Familial Restrictive 3
Cardiomyopathy, Restrictive, Familial, Type 3

Witkop Syndrome

Tooth And Nail Syndrome	Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome
Tns	Ectodermal Dysplasia 3, Witkop Type
ECTD3	Ectodermal Dysplasia 3, Tooth/Nail Type
Tooth-And-Nail Syndrome	Dysplasia Of Nails With Hypodontia
Nail Dysplasia With Hypodontia	Witkop'S Syndrome
Hypodontia - Dysplasia Of Nails	Hypodontia-Dysplasia Of Nails Syndrome
Hypodontia-Nail Dysgenesis Syndrome	Hypodontia-Nail Dysgenesis

Nephrosclerosis

Renal Sclerosis

Cardiomyopathy, Familial Restrictive, 2

RCM2	Restrictive Cardiomyopathy 2
Familial Restrictive Cardiomyopathy 2	Cardiomyopathy, Restrictive, Familial, Type 2

Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome	Wzs
Pierre Robin Syndrome With Fetal Chondrodysplasia	OSMEDA
Weissenbacher-Zweymüller Syndrome	Heterozygous Osmed
Stickler Syndrome, Type 3	Osmed, Heterozygous
Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly	Stickler Syndrome, Type Iii, Formerly
Stl3, Formerly	Piere-Robin Syndrome
Pierre Robin Malformation	Heterozygous Otospondylomegaepiphyseal Dysplasia
Autosomal Dominant Otospondylomegaepiphyseal Dysplasia	Ad Osmed
Stickler Syndrome Type 3	Stickler Syndrome, Non-Ocular Type
Stickler-Like Syndrome	Stickler Syndrome 3
Stickler Syndrome Non-Ocular Type	Stickler Syndrome Type Iii
Stl3	Weissenbacher-Zweymueller Syndrome
Stickler Syndrome, Type Iii	Pierre Robin Syndrome
Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant

Brachydactyly, Type A2

Brachydactyly Type A2	BDA2
Mohr-Wriedt Type Brachydactyly	Brachymesophalangy Ii
Brachymesophalangy Type 2	Brachymesophalangy 2
Brachydactyly, Mohr-Wriedt Type	Brachydactyly A2

Otosclerosis

Otospongiosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01540	BMP5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BMP5	MGD	MGI:88181
Rattus norvegicus	BMP5	RGD	RGD:1305979
Canis familiaris	BMP5	VGNC	VGNC:38481
Felis catus	BMP5	VGNC	VGNC:60134
Macaca mulatta	BMP5	VGNC	VGNC:70264
Bos taurus	BMP5	VGNC	VGNC:26520
Others	BMP5	NCBI