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BMP5 - bone morphogenetic protein 5 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 653

About BMP5

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,753,653-55,875,590 (from NCBI)

This gene has 1 transcript (splice variant), 197 orthologues, 31 paralogues and is associated with 70 phenotypes. Biased expression in placenta (RPKM 11.7), lung (RPKM 3.1) and 7 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]

BMP5 Products (3)

mRNA	Protein	Name
NM_001329754.2	NP_001316683.1	bone morphogenetic protein 5 isoform 2 precursor
NM_001329756.2	NP_001316685.1	bone morphogenetic protein 5 isoform 3 precursor
NM_021073.4	NP_066551.1	bone morphogenetic protein 5 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables BMP receptor binding	IDA IDA: Inferred from direct assay	7811286	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30097509	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	11580864	GOA
involved in negative regulation of aldosterone biosynthetic process	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of cortisol biosynthetic process	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19584291	GOA
involved in negative regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	19584291	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	11580864	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15516325	GOA
involved in positive regulation of dendrite development	IDA IDA: Inferred from direct assay	11580864	GOA
involved in positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	11865031	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15516325	GOA
involved in type B pancreatic cell development	IDA IDA: Inferred from direct assay	11865031	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP5 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
454 a.a.

Protein Preferred Names	Protein Names
bone morphogenetic protein 5

BMP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BMP5	P22003	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	BMP5	P22003	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	BMP5	P22003	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BMP5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75472	BMP-5 Protein, Human (HEK293, hFc)	NP_066551.1 (Q324-H454)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700028AF	Animal-Free BMP-5 Protein, Human (His)	P22003 (A317-H454)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Cardiomyopathy, Familial Restrictive, 3	RCM3 Restrictive Cardiomyopathy 3 Familial Restrictive Cardiomyopathy 3 Cardiomyopathy, Familial Restrictive 3 Cardiomyopathy, Restrictive, Familial, Type 3
Witkop Syndrome	Tooth And Nail Syndrome Hypoplastic Enamel-Onycholysis-Hypohidrosis Syndrome Tns Ectodermal Dysplasia 3, Witkop Type ECTD3 Ectodermal Dysplasia 3, Tooth/Nail Type Tooth-And-Nail Syndrome Dysplasia Of Nails With Hypodontia Nail Dysplasia With Hypodontia Witkop'S Syndrome Hypodontia - Dysplasia Of Nails Hypodontia-Dysplasia Of Nails Syndrome Hypodontia-Nail Dysgenesis Syndrome Hypodontia-Nail Dysgenesis
Nephrosclerosis	Renal Sclerosis
Cardiomyopathy, Familial Restrictive, 2	RCM2 Restrictive Cardiomyopathy 2 Familial Restrictive Cardiomyopathy 2 Cardiomyopathy, Restrictive, Familial, Type 2
Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant	Weissenbacher-Zweymuller Syndrome Wzs Pierre Robin Syndrome With Fetal Chondrodysplasia OSMEDA Weissenbacher-Zweymüller Syndrome Heterozygous Osmed Stickler Syndrome, Type 3 Osmed, Heterozygous Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly Stickler Syndrome, Type Iii, Formerly Stl3, Formerly Piere-Robin Syndrome Pierre Robin Malformation Heterozygous Otospondylomegaepiphyseal Dysplasia Autosomal Dominant Otospondylomegaepiphyseal Dysplasia Ad Osmed Stickler Syndrome Type 3 Stickler Syndrome, Non-Ocular Type Stickler-Like Syndrome Stickler Syndrome 3 Stickler Syndrome Non-Ocular Type Stickler Syndrome Type Iii Stl3 Weissenbacher-Zweymueller Syndrome Stickler Syndrome, Type Iii Pierre Robin Syndrome Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant
Brachydactyly, Type A2	Brachydactyly Type A2 BDA2 Mohr-Wriedt Type Brachydactyly Brachymesophalangy Ii Brachymesophalangy Type 2 Brachymesophalangy 2 Brachydactyly, Mohr-Wriedt Type Brachydactyly A2
Otosclerosis	Otospongiosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01540	BMP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19119	Bmp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25609	Bmp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BMP5	MGD	MGI:88181
Rattus norvegicus	BMP5	RGD	RGD:1305979
Canis familiaris	BMP5	VGNC	VGNC:38481
Felis catus	BMP5	VGNC	VGNC:60134
Macaca mulatta	BMP5	VGNC	VGNC:70264
Bos taurus	BMP5	VGNC	VGNC:26520
Others	BMP5	NCBI