1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. TGF-beta Superfamily
  4. Bone Morphogenetic Proteins (BMPs)
  5. Bone Morphogenetic Protein 5

Bone Morphogenetic Protein 5

Bone Morphogenetic Protein 5 (BMP-5) is a ligand protein with pleiotropic, belongs to TGFβ family. BMP/TGFβ signaling to involve in vascular and valvular homeostasis, which is a critical process of embryonic development[1]. And BMP/TGFβ signaling can be terminated by inhibitory SMADs including SMAD6 and SMAD7, which are activated and induced by BMP signaling and switch off BMP signaling via multiple mechanisms[2]. BMP-5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis (OA) progression by downregulating activity in the p38/ERK signaling pathway[3]. BMP-5 initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2[4]. BMP-5 also triggers signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation[5]. BMP-5 specific expressing in neural crest progenitor cells is sufficient to induce cell proliferation through the Mek-Erk-Id3 signaling cascade, whereas disruption of this signaling cascade had no effect on cell survival[6].

Cat. No. Product Name / Synonyms Species Source
  • HY-P75472
    BMP-5 Protein, Human (HEK293, hFc)

    Bone morphogenetic protein 5; BMP-5

    Human HEK293
    Bone morphogenetic protein 5 (BMP-5) is a pleiotropic ligand protein belonging to the TGFβ family, which is mainly expressed in the lung and liver. After BMP-5 silencing, the activity of p38/ERK signaling pathway can be down-regulated to inhibit chondrocyte senescence and apoptosis and knee arthritis (OA). Bmp-5 initiates typical BMP signaling cascades by binding to type I receptor BMPR1A and type II receptor BMPR2, or triggers signals through atypical pathways such as MAPK p38 signaling cascades to promote chondrogenic differentiation. The total length of human BMP-5 protein is 454 amino acids (M1-H454), with 4 glycosylation domains. BMP-5 Protein, Human (HEK293, hFc) has a total length of 131 amino acids (Q324-H454), is expressed in HEK293 cells with a N-terminal hFc-tag.
  • HY-P700028AF
    Animal-Free BMP-5 Protein, Human (His)

    Bone morphogenetic protein 5; BMP5

    Human E. coli
    BMP-5 protein is an important member of the TGF-β superfamily and is essential for cartilage and bone formation as well as neurogenesis. It activates canonical BMP signaling through BMPR1A and BMPR2 and phosphorylates SMAD1/5/8 for gene transcription regulation. Animal-Free BMP-5 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free BMP-5 Protein, Human (His) is 138 a.a., with molecular weight of ~16.57 kDa.
Cat. No. Product Name Effect Purity