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Pink1 - PTEN induced putative kinase 1 Gene

Also Known as BRPK; mFLJ00387; 1190006F07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68943

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein kinase activity. Involved in several processes, including negative regulation of apoptotic process; protein stabilization; and regulation of gene expression. Acts upstream of or within several processes, including positive regulation of dopamine secretion; positive regulation of dopaminergic synaptic transmission; and positive regulation of histone deacetylase activity. Located in endoplasmic reticulum and mitochondrial inner membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Parkinson's disease 6. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 6. Orthologous to human PINK1 (PTEN induced kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pink1 Products (1)

mRNA	Protein	Name
NM_026880.2	NP_081156.2	serine/threonine-protein kinase PINK1, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14607334	MGI
enables kinase activity	IDA IDA: Inferred from direct assay	14607334	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14607334	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	31536960	MGI
enables protein serine kinase activity	IMP IMP: Inferred from mutant phenotype	32484300	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14607334	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	24784582	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of catecholamine secretion	IMP IMP: Inferred from mutant phenotype	17563363	MGI
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	24553947	MGI
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	18687901	MGI
involved in cellular response to toxic substance	IMP IMP: Inferred from mutant phenotype	22511790	MGI
acts upstream of dopamine secretion	IMP IMP: Inferred from mutant phenotype	17563363	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17563363	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14607334	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24475098	MGI
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	24553947	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18560593	MGI
acts upstream of or within positive regulation of catecholamine secretion	IMP IMP: Inferred from mutant phenotype	17563363	MGI
acts upstream of or within positive regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	17563363	MGI
acts upstream of or within positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	24652937	MGI
acts upstream of or within positive regulation of synaptic transmission, dopaminergic	IMP IMP: Inferred from mutant phenotype	17563363	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24553947	MGI
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	24553947	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14607334	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19229105	MGI
involved in regulation of hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	24553947	MGI
involved in regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	22511790	MGI
involved in respiratory electron transport chain	IMP IMP: Inferred from mutant phenotype	18687901	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	31536960	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	24652937	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	31536960	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PINK1, mitochondrial	PTEN-induced putative kinase protein 1

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17355B	Dexpramipexole	Activator	99.56%	Yes

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15887	MG 149	Inhibitor	99.60%	Unkown
HY-N3463	Isopimaric acid	Inhibitor	99.88%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pink1	NCBI	NCBI:65018