VRK2 - VRK serine/threonine kinase 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7444

About VRK2

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:57,907,592-58,159,920 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 12 paralogues. Ubiquitous expression in adrenal (RPKM 6.3), appendix (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate Apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

VRK2 Products (9)

mRNA Protein Name
NM_001130480.2 NP_001123952.1 serine/threonine-protein kinase VRK2 isoform 1
NM_001130481.2 NP_001123953.1 serine/threonine-protein kinase VRK2 isoform 1
NM_001130482.2 NP_001123954.1 serine/threonine-protein kinase VRK2 isoform 2
NM_001130483.2 NP_001123955.1 serine/threonine-protein kinase VRK2 isoform 3
NM_001288836.1 NP_001275765.1 serine/threonine-protein kinase VRK2 isoform 4
NM_001288837.2 NP_001275766.1 serine/threonine-protein kinase VRK2 isoform 1
NM_001288838.2 NP_001275767.1 serine/threonine-protein kinase VRK2 isoform 3
NM_001288839.2 NP_001275768.1 serine/threonine-protein kinase VRK2 isoform 4
NM_006296.7 NP_006287.2 serine/threonine-protein kinase VRK2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16963744 GOA
enables protein domain specific binding IDA
IDA: Inferred from direct assay
22572157 GOA
enables protein kinase binding IDA
IDA: Inferred from direct assay
22572157 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14645249 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
17709393 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
14645249 GOA
involved in regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
20679487 GOA
involved in regulation of interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18286207 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16704422 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
22572157 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
18286207 GOA
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
18286207 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16704422 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
22572157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VRK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (30 - 289)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase VRK2

  • vaccinia related kinase 2

VRK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
VRK2 Q86Y07 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
VRK2 Q86Y07 TMEM88 Homo sapiens Q6PEY1
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 TMEM88 Homo sapiens Q6PEY1
Y2H Array
32296183
Intra
VRK2 Q86Y07 TBXA2R Homo sapiens Q0VAB0
Y2H Array
32296183
Intra
VRK2 Q86Y07 TBXA2R Homo sapiens Q0VAB0
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Pull Down
20679487
Intra
VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Anti Tag CoIP
20679487
Intra
VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Confocal
20679487
Intra
VRK2 Q86Y07 KSR1 Homo sapiens Q8IVT5
Confocal
22752157
Intra
VRK2 Q86Y07 MAP2K1 Homo sapiens Q02750
Pull Down
20679487
Intra
VRK2 Q86Y07 MAP2K1 Homo sapiens Q02750
CoIP
20679487
Intra
VRK2 Q86Y07 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
Intra
VRK2 Q86Y07 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
VRK2 Q86Y07 TMEM205 Homo sapiens Q6UW68
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 TMEM205 Homo sapiens Q6UW68
Y2H Array
32296183
Intra
VRK2 Q86Y07 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra
VRK2 Q86Y07 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
VRK2 Q86Y07 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
VRK2 Q86Y07 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross
VRK2 Q86Y07 ear_ebvb9 Epstein-Barr virus P03182
Confocal
16963744
Cross
VRK2 Q86Y07 ear_ebvb9 Epstein-Barr virus P03182
Pull Down
16963744
Cross: Cross-species interaction Intra: Intraspecies interaction

VRK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89931 VRK2 Antibody (YA9275) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Vaccinia
Pontocerebellar Hypoplasia, Type 8

  • Pontocerebellar Hypoplasia Type 8

  • PCH8

  • Pontocerebellar Hypoplasia Due To Chmp1a Mutation

  • Pontocerebellar Hypoplasia 8

  • Hypoplasia, Pontocerebellar, Type 8
Pontocerebellar Hypoplasia, Type 1a

  • Pontocerebellar Hypoplasia Type 1a

  • PCH1A

  • Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

  • Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

  • Pch1

  • Pontocerebellar Hypoplasia 1a

  • Hypoplasia, Pontocerebellar, Type 1a

  • Pontocerebellar Hypoplasia Type 1
Developmental And Epileptic Encephalopathy 94

  • Epileptic Encephalopathy, Childhood-Onset

  • Eeoc

  • DEE94

  • Childhood Onset Epileptic Encephalopathy

  • Encephalopathy, Epileptic, Childhood-Onset
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Chromosome 2p16.1-P15 Deletion Syndrome

  • 2p15p16.1 Microdeletion Syndrome

  • 2p15-P16.1 Microdeletion Syndrome

  • Del(2)(P15p16.1)

  • Monosomy 2p15p16.1

  • Monosomy 2p15-P16.1
Pontocerebellar Hypoplasia, Type 1e

  • Pontocerebellar Hypoplasia Type 1

  • PCH1E

  • Norman Disease

  • Pch1

  • Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

  • Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

  • Pontocerebellar Hypoplasia Type 1e

  • Pontocerebellar Hypoplasia 1e

  • Doid:0112322

  • Doid:0112330
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

  • Adnfle

  • Autosomal Dominant Sleep-Related Hypermotor Epilepsy

  • Enfl

  • Benign Familial Infantile Seizures 6

  • Benign Familial Infantile Seizures, 6

  • Nocturnal Frontal Lobe Epilepsy-4

  • Enfl1

  • Epilepsy, Nocturnal Frontal Lobe, 1

  • Epilepsy, Nocturnal Frontal Lobe, Type 1
Epilepsy, Myoclonic Juvenile

  • Juvenile Myoclonic Epilepsy

  • Janz Syndrome

  • Jme

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

  • EJM

  • Myoclonic Epilepsy, Juvenile

  • Petit Mal, Impulsive

  • Myoclonic Epilepsy, Juvenile 1

  • Myoclonic Epilepsy, Juvenile, 1

  • Adolescent Myoclonic Epilepsy

  • Juvenile Myoclonus Epilepsy

  • Juvenile Myoclonic Epilepsy 1

  • EJM1

  • Petit Mal Impulsive

  • Susceptibility To Juvenile Myoclonic Epilepsy 1

  • Myoclonic Epilepsy Juvenile

  • Epilepsy, Myoclonic, Juvenile

  • Myoclonic Epilepsy Of Janz

  • Jme - [Juvenile Myoclonic Epilepsy]
Nanophthalmos

  • Nanophthalmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N8692 Dihydrobaicalein Inhibitor 99.94% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus VRK2 MGD MGI:1917172
Rattus norvegicus VRK2 RGD RGD:1311585
Macaca mulatta VRK2 VGNC VGNC:81604
Felis catus VRK2 VGNC VGNC:83479
Canis familiaris VRK2 VGNC VGNC:48303
Bos taurus VRK2 VGNC VGNC:36835
Others VRK2 NCBI