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RNF112 - ring finger protein 112 Gene

Also Known as BFP; ZNF179

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7732

About RNF112

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,411,232-19,417,276 (from NCBI)

This gene has 5 transcripts (splice variants), 129 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues.

Summary

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RNF112 Products (1)

mRNA	Protein	Name
NM_007148.5	NP_009079.2	RING finger protein 112

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in neuron differentiation	IDA IDA: Inferred from direct assay	28684796	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	28684796	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF112 Protein Structure

zf-C3HC4

GBP

0
100
200
300
400
500
600
631 a.a.

Protein Preferred Names	Protein Names
RING finger protein 112	brain finger protein

RNF112 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RNF112	Q9ULX5	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	PARK7	Homo sapiens	Q99497	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PARK7	Homo sapiens	Q99497	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PARK7	Homo sapiens	Q99497	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	RNF112	Q9ULX5	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRKN	Homo sapiens	O60260-5	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRKN	Homo sapiens	O60260-5	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	PRKN	Homo sapiens	O60260-5	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	ELAVL4	Homo sapiens	P26378-2	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	ELAVL4	Homo sapiens	P26378-2	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	ELAVL4	Homo sapiens	P26378-2	Y2H Array	32814053
Intra	RNF112	Q9ULX5	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	RNF112	Q9ULX5	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	RNF112	Q9ULX5	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	RNF112	Q9ULX5	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	RNF112	Q9ULX5	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	RNF112	Q9ULX5	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PHYH	Homo sapiens	O14832	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PHYH	Homo sapiens	O14832	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PHYH	Homo sapiens	O14832	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	GRN	Homo sapiens	P28799	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	GRN	Homo sapiens	P28799	Y2H Array	32814053
Intra	RNF112	Q9ULX5	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	RNF112	Q9ULX5	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	RNF112	Q9ULX5	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	RNF112	Q9ULX5	DBH	Homo sapiens	P09172	Y2H Array	32814053
Intra	RNF112	Q9ULX5	DBH	Homo sapiens	P09172	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Bilateral Generalized Polymicrogyria	Bilateral Generalised Polymicrogyria
Acute Diarrhea
Miller Fisher Syndrome	Cranial Variant Of Gbs Fisher'S Syndrome Miller-Fisher Variant Of Guillain-Barre Syndrome Miller-Fisher Syndrome Cranial Variant Of Guillain-Barré Syndrome Cranial Variant Of Guillain-Barre Syndrome Fisher Syndrome
Gummatous Syphilis
Bilateral Frontal Polymicrogyria
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
Yaws	Frambesia Frambesia Tropica Bouba Frambosie Polypapilloma Tropicum Thymosis Endemic Treponematoses Treponema Pertenue Infection Pian Framboesia Framboesia Tropica Castellani Infection By Treponema Pertenue Parangi Framboesioma Chancre Of Yaws Primary Framboesia Initial Lesions Of Yaws Mother Yaw Initial Framboesia
Loeys-Dietz Syndrome 2	LDS2 Aat3 Marfan Syndrome Type 2 Aortic Aneurysm, Familial Thoracic 3 Marfan Syndrome Type Ii Loeys-Dietz Syndrome Type 2 Mfs2 Marfan Syndrome, Type Ii, Formerly Familial Throacic Aortic Aneurysm 3 Familial Aortic Aneurysm Thoracic Type 3 Taad2 Thoracic Aortic Aneurysms And Dissection 2 Aneurysm, Aortic, Thoracic, Familial, Type 3 Loeys-Dietz Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12037	RNF112 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF112	MGD	MGI:106611
Canis familiaris	RNF112	VGNC	VGNC:45622
Rattus norvegicus	RNF112	RGD	RGD:3986
Macaca mulatta	RNF112	VGNC	VGNC:76724
Bos taurus	RNF112	VGNC	VGNC:34011
Felis catus	RNF112	VGNC	VGNC:64664
Others	RNF112	NCBI