TRPM3 - transient receptor potential cation channel subfamily M member 3 Gene

Homo sapiens

Also known as GON-2; MLSN2; LTRPC3

Gene ID: 80036 | Gene type: protein coding

About TRPM3

Cytogenetic location: 9q21.12-q21.13 Genomic coordinates (GRCh38): 9:70,529,060-71,446,971 (from NCBI)

This gene has 28 transcripts (splice variants), 224 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.0), brain (RPKM 0.8) and 2 other tissues.

Summary

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TRPM3 Products(23)

mRNA	Protein	Name
NM_001007470.3	NP_001007471.1	transient receptor potential cation channel subfamily M member 3 isoform c
NM_001007471.4	NP_001007472.2	transient receptor potential cation channel subfamily M member 3 isoform k
NM_001366141.2	NP_001353070.1	transient receptor potential cation channel subfamily M member 3 isoform i
NM_001366142.2	NP_001353071.1	transient receptor potential cation channel subfamily M member 3 isoform j
NM_001366143.2	NP_001353072.1	transient receptor potential cation channel subfamily M member 3 isoform w
NM_001366144.2	NP_001353073.1	transient receptor potential cation channel subfamily M member 3 isoform l
NM_001366145.2	NP_001353074.1	transient receptor potential cation channel subfamily M member 3 isoform m
NM_001366146.2	NP_001353075.1	transient receptor potential cation channel subfamily M member 3 isoform n
NM_001366147.2	NP_001353076.1	transient receptor potential cation channel subfamily M member 3 isoform o
NM_001366148.2	NP_001353077.1	transient receptor potential cation channel subfamily M member 3 isoform p
NM_001366149.2	NP_001353078.1	transient receptor potential cation channel subfamily M member 3 isoform q
NM_001366150.2	NP_001353079.1	transient receptor potential cation channel subfamily M member 3 isoform r
NM_001366151.2	NP_001353080.1	transient receptor potential cation channel subfamily M member 3 isoform s
NM_001366152.2	NP_001353081.1	transient receptor potential cation channel subfamily M member 3 isoform t
NM_001366153.2	NP_001353082.1	transient receptor potential cation channel subfamily M member 3 isoform u
NM_001366154.2	NP_001353083.1	transient receptor potential cation channel subfamily M member 3 isoform v
NM_020952.6	NP_066003.3	transient receptor potential cation channel subfamily M member 3 isoform a
NM_024971.7	NP_079247.5	transient receptor potential cation channel subfamily M member 3 isoform b
NM_206944.5	NP_996827.3	transient receptor potential cation channel subfamily M member 3 isoform d
NM_206945.5	NP_996828.3	transient receptor potential cation channel subfamily M member 3 isoform e
NM_206946.5	NP_996829.3	transient receptor potential cation channel subfamily M member 3 isoform f
NM_206947.5	NP_996830.3	transient receptor potential cation channel subfamily M member 3 isoform g
NM_206948.4	NP_996831.1	transient receptor potential cation channel subfamily M member 3 isoform h

TRPM3 Protein Structure

Ion_trans

0
300
600
900
1200
1500
1707 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily M member 3

long transient receptor potential channel 3

Related Diseases

Diseases

Alias

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Retinal Dystrophy And Iris Coloboma With Or Without Congenital Cataract

Familial Progressive Retinal Dystrophy-Iris Coloboma-Congenital Cataract Syndrome	Retinal Dystrophy And Iris Coloboma With Or Without Cataract
RDICC

Autosomal Dominant Non-Syndromic Intellectual Disability

Luminal Breast Carcinoma B

Luminal B Breast Carcinoma

Dentin Sensitivity

Sensitive Dentin

Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes	ASGD5
Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes

Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix

Familial Episodic Pain Syndrome

Feps

Episodic Pain Syndrome, Familial, 1

FEPS1	Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement
Familial Episodic Pain Syndrome 1

Hyperhidrosis, Gustatory

Frey Syndrome	Gustatory Sweating
Auriculotemporal Nerve Syndrome	Gustatory Hyperhidrosis
Frey'S Syndrome	Sweating, Gustatory
HYPRG	Baillarger Syndrome
Hyperhidrosis Gustatory	Auriculotemporal Syndrome

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Otosclerosis

Otospongiosis

Mucolipidosis Iv

Mucolipidosis Type Iv	ML4
Sialolipidosis	Mucolipidosis Type 4
Ganglioside Sialidase Deficiency	Mliv
Ml Iv	Berman Syndrome
Ganglioside Neuraminidase Deficiency	Ml 4
Mucolipidosis 4	Type Iv Mucolipidosis
Gangliosidoses

Chronic Fatigue Syndrome

Myalgic Encephalomyelitis	Postviral Fatigue Syndrome
Cfs	Myalgic Encephalitis
Encephalomyelitis, Myalgic	Chronic Fatigue
Fatigue Syndrome, Chronic	Benign Myalgic Encephalomyelitis
Akureyri	Akureyri Disease
Cfs - [Chronic Fatigue Syndrome]	Epidemic Neuromyasthenia
Myalgic Encephalomyelitis Syndrome	Me - [Myalgic Encephalomyelitis]
Pvfs - [Postviral Fatigue Syndrome]	Neuromyasthenia
Iceland Disease	Icelandic Disease

Kabuki Syndrome 1

Kabuki Syndrome	Niikawa-Kuroki Syndrome
Kabuki Make-Up Syndrome	Kms
KABUK1	Kabuki Make Up Syndrome
Nks	Kabuki Makeup Syndrome
Kabuki Syndrome, Type 1

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (9)

Cat. No.	Product Name	Purity	Rare Diseases
HY-17386	Rosiglitazone	99.90%	Yes
HY-B0151	Pregnenolone	99.87%	Unkown
HY-14600	Rosiglitazone maleate	99.88%	Yes
HY-110189	Pregnenolone monosulfate sodium	≥98.0%	Unkown
HY-17386A	Rosiglitazone hydrochloride	99.31%	Yes
HY-B1739	Pregnenolone monosulfate	99.22%	Unkown
HY-17386B	Rosiglitazone potassium	/	Unkown
HY-14600R	Rosiglitazone maleate (Standard)	/	Unkown
HY-B0151R	Pregnenolone (Standard)	/	Unkown

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110220	CIM0216	Agonist	99.91%	Unkown
HY-108451	Ononetin	Antagonist	≥98.0%	Unkown
HY-B0151S2	Pregnenolone-d4-1		99%	Unkown
HY-W089922	D-erythro-Sphingosine hydrochloride	Activator	≥97.0%	Unkown
HY-110189S	Pregnenolone monosulfate sodium-13C2,d2		/	Unkown
HY-110189S1	Pregnenolone monosulfate-d4 sodium		/	Unkown
HY-17386S	Rosiglitazone-d3		/	Unkown
HY-B0151S	Pregnenolone-d4		/	Unkown
HY-B0151S1	Pregnenolone-13C2,d2		/	Unkown
HY-RS15113	TRPM3 Human Pre-designed siRNA Set A		/	Unkown
HY-17386S1	Rosiglitazone-d4		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRPM3	VGNC	VGNC:79104
Canis familiaris	TRPM3	VGNC	VGNC:47874
Rattus norvegicus	TRPM3	RGD	RGD:1304888
Felis catus	TRPM3	VGNC	VGNC:66589
Bos taurus	TRPM3	VGNC	VGNC:55085
Mus musculus	TRPM3	MGD	MGI:2443101

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