RAB1B - RAB1B, member RAS oncogene family Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81876

About RAB1B

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,268,639-66,277,492 (from NCBI)

This gene has 2 transcripts (splice variants), 235 orthologues and 68 paralogues. Ubiquitous expression in prostate (RPKM 64.5), fat (RPKM 64.0) and 25 other tissues.

Summary

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

RAB1B Products (1)

mRNA	Protein	Name
NM_030981.3	NP_112243.1	ras-related protein Rab-1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	20937701	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15796781	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	26209634	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IGI IGI: Inferred from genetic interaction	21680502	GOA
NOT involved in establishment of endothelial intestinal barrier	IMP IMP: Inferred from mutant phenotype	23885123	GOA
involved in positive regulation of glycoprotein metabolic process	IGI IGI: Inferred from genetic interaction	21680502	GOA
involved in regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	20545908	GOA
involved in virion assembly	IGI IGI: Inferred from genetic interaction	21680502	GOA
NOT involved in virion assembly	IMP IMP: Inferred from mutant phenotype	21680502	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in phagophore assembly site membrane	IDA IDA: Inferred from direct assay	20545908	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB1B Protein Structure

Ras

0
100
201 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rab-1B	small GTP-binding protein

RAB1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAB1B	Q9H0U4	OCRL	Homo sapiens	Q01968	FPS	21378754
Intra	RAB1B	Q9H0U4	RABIF	Homo sapiens	P47224	Anti Tag CoIP	28514442
Intra	RAB1B	Q9H0U4	RABIF	Homo sapiens	P47224	Y2H Prey Pooling	32296183
Intra	RAB1B	Q9H0U4	RABIF	Homo sapiens	P47224	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAB1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75993	RAB1B Protein, Human (HEK293, Fc)	Q9H0U4 (M1-G199)	≥ 90%, as determined by reducing SDS-PAGE.

RAB1B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84787	Rab1b Antibody (YA4484)	IHC-P, FC, ELISA	Human
HY-P84787A	Rab1b Antibody (YA4484)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Hypotrichosis 3	HYPT3 Hypotrichosis Simplex Of The Scalp 2 Htss2 Hypotrichosis, Type 3
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Pontiac Fever
Septicemic Plague	Plague, Septicemic
Immunodeficiency 54	Natural Killer Cell Deficiency, Familial Isolated Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency IMD54 Nkcd Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect Nkgcd Familial Isolated Natural Killer Cell Deficiency Primary Immunodeficiency Due To Mcm4 Deficiency
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11529	RAB1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19736	Rab1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26232	Rab1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAB1B	VGNC	VGNC:56276
Rattus norvegicus	RAB1B	RGD	RGD:1642882
Mus musculus	RAB1B	MGD	MGI:1923558
Canis familiaris	RAB1B	VGNC	VGNC:52037