SLC25A11 - solute carrier family 25 member 11 Gene

Homo sapiens

Also known as OGC; PGL6; SLC20A4

Gene ID: 8402 | Gene type: protein coding

About SLC25A11

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,937,130-4,940,046 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues, 49 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 61.1), kidney (RPKM 32.4) and 24 other tissues.

Summary

The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

SLC25A11 Products(3)

mRNA	Protein	Name
NM_001165417.2	NP_001158889.1	mitochondrial 2-oxoglutarate/malate carrier protein isoform 2
NM_001165418.2	NP_001158890.1	mitochondrial 2-oxoglutarate/malate carrier protein isoform 3
NM_003562.5	NP_003553.2	mitochondrial 2-oxoglutarate/malate carrier protein isoform 1

SLC25A11 Protein Structure

Mito_carr

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

mitochondrial 2-oxoglutarate/malate carrier protein

OGCP

Related Diseases

Diseases

Alias

Paragangliomas 6

PGL6

Hereditary Paraganglioma-Pheochromocytoma Syndromes

Hereditary Pheochromocytoma-Paraganglioma	Hereditary Paraganglioma-Pheochromocytoma
Familial Pheochromocytoma-Paraganglioma	Paragangliomas 2
Paragangliomas 3	Paragangliomas 4
Sdhx-Related Paraganglioma-Pheochromocytoma	Familial Paraganglioma Syndrome
Familial Paraganglioma-Pheochromocytoma Syndromes	Fpgl
Fpgl/Pheo	Paragangliomas 1
Paraganglioma

Breast Leiomyosarcoma

Leiomyosarcoma Of The Breast

Oculogyric Crisis

Aromatic L-Amino Acid Decarboxylase Deficiency

Aadc Deficiency	Dopa Decarboxylase Deficiency
Ddc Deficiency	Aromatic Amino Acid Decarboxylase Deficiency
Deficiency Of Aromatic-L-Amino-Acid Decarboxylase	AADCD
Aromatic-L-Amino-Acid Decarboxylase Deficiency	Aromatic L-Amino-Acid Decarboxylase Deficiency

Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral	Agc1 Deficiency
Epileptic Encephalopathy, Early Infantile, 39	DEE39
Eiee39	Aspartate-Glutamate Carrier 1 Deficiency
Epileptic Encephalopathy With Global Cerebral Demyelination	Developmental And Epileptic Encephalopathy, 39
Early Infantile Epileptic Encephalopathy 39	Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency
Global Cerebral Hypomyelination	Hereditary Central Nervous System Demyelinating Diseases

Lung Giant Cell Carcinoma

Carcinoma, Giant Cell	Giant Cell Carcinoma
Giant Cell Lung Carcinoma	Carcinoma Giant Cell
Giant Cell Carcinoma Of Lung

Persistent Generalized Lymphadenopathy

Pgl	Persistant Generalized Lymphadenopathy

Postencephalitic Parkinson Disease

Postencephalitic Parkinsonism

Parkinson Disease, Postencephalitic

Pancreatic Mucinous Cystadenoma

Pancreatic Mucinous Cystic Neoplasm

Pancreatic Mucinous-Cystic Neoplasm

Citrullinemia, Type Ii, Adult-Onset

Citrin Deficiency	CTLN2
Citrullinemia Type Ii	Adult-Onset Citrullinemia Type 2
Adult-Onset Type Ii Citrullinemia	Citrullinemia, Adult-Onset Type Ii
Adult-Onset Citrin Deficiency	Adult-Onset Citrullinemia Type Ii
Citrullinemia Type 2	Citrullinemia 2
Citrullinemia, Type Ii

Hyperphenylalaninemia, Bh4-Deficient, A

6-Pyruvoyl-Tetrahydropterin Synthase Deficiency	Pts Deficiency
HPABH4A	Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To Pts Deficiency
Ptsd	Bh4-Deficient Hyperphenylalaninemia A
Hyperphenylalaninemia Due To 6-Pyruvoyltetrahydropterin Synthase Deficiency	Tetrahydobioperin-Deficient Hyperphenylalaninemia Due To Pts Deficiency
Hyperphenylalanemia, Bh4-Deficient, A	Hyperphenylalaninemia Due To 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
6-Pyruvoyltetrahydropterin Synthase Deficiency	Hyperphenylalaninemia Tetrahydrobiopterin-Deficient Due To Pts Deficiency
Ptpsd	Hyperphenylalaninemia, Bh4-Deficient, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13091	SLC25A11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC25A11	VGNC	VGNC:46291
Macaca mulatta	SLC25A11	VGNC	VGNC:77429
Mus musculus	SLC25A11	MGD	MGI:1915113
Bos taurus	SLC25A11	VGNC	VGNC:34742
Felis catus	SLC25A11	VGNC	VGNC:65253
Rattus norvegicus	SLC25A11	RGD	RGD:708476

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