SLC25A11 - solute carrier family 25 member 11 Gene

Also Known as OGC; PGL6; SLC20A4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8402

About SLC25A11

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,937,130-4,940,046 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues, 49 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 61.1), kidney (RPKM 32.4) and 24 other tissues.

Summary

The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or Other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]

SLC25A11 Products (3)

mRNA	Protein	Name
NM_001165417.2	NP_001158889.1	mitochondrial 2-oxoglutarate/malate carrier protein isoform 2
NM_001165418.2	NP_001158890.1	mitochondrial 2-oxoglutarate/malate carrier protein isoform 3
NM_003562.5	NP_003553.2	mitochondrial 2-oxoglutarate/malate carrier protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC25A11 Protein Structure

Mito_carr

0
100
200
300
314 a.a.

Protein Preferred Names	Protein Names
mitochondrial 2-oxoglutarate/malate carrier protein	OGCP

SLC25A11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC25A11	Q02978	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	SLC25A11	Q02978	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	SLC25A11	Q02978	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	SLC25A11	Q02978	AHCYL1	Homo sapiens	O43865	Validated Y2H	32814053
Intra	SLC25A11	Q02978	AHCYL1	Homo sapiens	O43865	Y2H Array	32814053
Intra	SLC25A11	Q02978	AHCYL1	Homo sapiens	O43865	Y2H Pooling	32814053
Intra	SLC25A11	Q02978	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	SLC25A11	Q02978	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	SLC25A11	Q02978	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	SLC25A11	Q02978	SMIM26	Homo sapiens	A0A096LP01	Anti Tag CoIP	37009826
Intra	SLC25A11	Q02978	CDH1	Homo sapiens	P12830	Y2H Pooling	32814053
Intra	SLC25A11	Q02978	CDH1	Homo sapiens	P12830	Y2H Array	32814053
Intra	SLC25A11	Q02978	CDH1	Homo sapiens	P12830	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Paragangliomas 6	PGL6
Hereditary Paraganglioma-Pheochromocytoma Syndromes	Hereditary Pheochromocytoma-Paraganglioma Hereditary Paraganglioma-Pheochromocytoma Familial Pheochromocytoma-Paraganglioma Paragangliomas 2 Paragangliomas 3 Paragangliomas 4 Sdhx-Related Paraganglioma-Pheochromocytoma Familial Paraganglioma Syndrome Familial Paraganglioma-Pheochromocytoma Syndromes Fpgl Fpgl/Pheo Paragangliomas 1 Paraganglioma
Breast Leiomyosarcoma	Leiomyosarcoma Of The Breast
Oculogyric Crisis
Aromatic L-Amino Acid Decarboxylase Deficiency	Aadc Deficiency Dopa Decarboxylase Deficiency Ddc Deficiency Aromatic Amino Acid Decarboxylase Deficiency Deficiency Of Aromatic-L-Amino-Acid Decarboxylase AADCD Aromatic-L-Amino-Acid Decarboxylase Deficiency Aromatic L-Amino-Acid Decarboxylase Deficiency
Developmental And Epileptic Encephalopathy 39	Hypomyelination, Global Cerebral Agc1 Deficiency Epileptic Encephalopathy, Early Infantile, 39 DEE39 Eiee39 Aspartate-Glutamate Carrier 1 Deficiency Epileptic Encephalopathy With Global Cerebral Demyelination Developmental And Epileptic Encephalopathy, 39 Early Infantile Epileptic Encephalopathy 39 Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency Global Cerebral Hypomyelination Hereditary Central Nervous System Demyelinating Diseases
Lung Giant Cell Carcinoma	Carcinoma, Giant Cell Giant Cell Carcinoma Giant Cell Lung Carcinoma Carcinoma Giant Cell Giant Cell Carcinoma Of Lung
Persistent Generalized Lymphadenopathy	Pgl Persistant Generalized Lymphadenopathy
Postencephalitic Parkinson Disease	Postencephalitic Parkinsonism Parkinson Disease, Postencephalitic
Pancreatic Mucinous Cystadenoma	Pancreatic Mucinous Cystic Neoplasm Pancreatic Mucinous-Cystic Neoplasm
Citrullinemia, Type Ii, Adult-Onset	Citrin Deficiency CTLN2 Citrullinemia Type Ii Adult-Onset Citrullinemia Type 2 Adult-Onset Type Ii Citrullinemia Citrullinemia, Adult-Onset Type Ii Adult-Onset Citrin Deficiency Adult-Onset Citrullinemia Type Ii Citrullinemia Type 2 Citrullinemia 2 Citrullinemia, Type Ii
Hyperphenylalaninemia, Bh4-Deficient, A	6-Pyruvoyl-Tetrahydropterin Synthase Deficiency Pts Deficiency HPABH4A Hyperphenylalaninemia, Tetrahydrobiopterin-Deficient, Due To Pts Deficiency Ptsd Bh4-Deficient Hyperphenylalaninemia A Hyperphenylalaninemia Due To 6-Pyruvoyltetrahydropterin Synthase Deficiency Tetrahydobioperin-Deficient Hyperphenylalaninemia Due To Pts Deficiency Hyperphenylalanemia, Bh4-Deficient, A Hyperphenylalaninemia Due To 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency 6-Pyruvoyltetrahydropterin Synthase Deficiency Hyperphenylalaninemia Tetrahydrobiopterin-Deficient Due To Pts Deficiency Ptpsd Hyperphenylalaninemia, Bh4-Deficient, Type A

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13091	SLC25A11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC25A11	VGNC	VGNC:46291
Macaca mulatta	SLC25A11	VGNC	VGNC:77429
Mus musculus	SLC25A11	MGD	MGI:1915113
Bos taurus	SLC25A11	VGNC	VGNC:34742
Felis catus	SLC25A11	VGNC	VGNC:65253
Rattus norvegicus	SLC25A11	RGD	RGD:708476
Others	SLC25A11	NCBI