Sfrp1 - secreted frizzled-related protein 1 Gene

Also Known as sFRP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84402

About Sfrp1

Primary_assembly 16: 68,575,763-68,614,286 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 223 orthologues, 15 paralogues and is associated with 10 phenotypes. Biased expression in Kidney (RPKM 136.3), Spleen (RPKM 19.3) and 9 other tissues.

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of osteoclast differentiation; and osteoblast differentiation. Predicted to be located in cell surface; collagen-containing extracellular matrix; and cytosol. Predicted to be active in extracellular space. Orthologous to human SFRP1 (secreted Frizzled related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp1 Products (1)

mRNA Protein Name
NM_001276712.2 NP_001263641.2 secreted frizzled-related protein 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to prostaglandin E stimulus IEP
IEP: Inferred from expression pattern
16149051 RGD
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
16149051 RGD
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
16149051 RGD
involved in negative regulation of osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
17540629 RGD
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
16149051 RGD
involved in regulation of ossification IMP
IMP: Inferred from mutant phenotype
15677765 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sfrp1 Protein Structure

CRD_SFRP1

CRD_SFRP1: cd07443 (51 - 174)

NTR_Sfrp1_like

NTR_Sfrp1_like: cd03580 (182 - 305)

  • 0
  • 100
  • 200
  • 300
  • 314 a.a.
Protein Preferred Names Protein Names

secreted frizzled-related protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10858 WAY 316606 99.24% Unkown
HY-117738 Benarthin Inhibitor 95.79% Unkown
HY-10860 WAY-362692 99.91% Unkown
HY-10858A WAY 316606 hydrochloride 98.04% Unkown
HY-202887 BCN512 Inhibitor 99.77% Unkown
HY-RS12772 SFRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12773 Sfrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12774 Sfrp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180876 SFRP1 modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfrp1 NCBI NCBI:6422