SFRP1 - secreted frizzled related protein 1 Gene

Also Known as FRP; FRP1; FrzA; FRP-1; SARP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6422

About SFRP1

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,261,962-41,309,473 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 15 paralogues. Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues.

Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with Cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

SFRP1 Products (1)

mRNA	Protein	Name
NM_003012.5	NP_003003.3	secreted frizzled-related protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	17462603	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	10347172	GOA
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	14581477	GOA
enables frizzled binding	IPI IPI: Inferred from physical interaction	1927703	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	9192640	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10347172	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10347172	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18787224	GOA
involved in cellular response to BMP stimulus	IEP IEP: Inferred from expression pattern	16149051	GOA
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	11932307	GOA
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	18941195	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: Inferred from direct assay	17500071	GOA
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	17500071	GOA
involved in cellular response to heparin	IDA IDA: Inferred from direct assay	17500071	GOA
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	11932307	GOA
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	16149051	GOA
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	16149051	GOA
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	9724099	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	16149051	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	9391078	GOA
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	16149051	GOA
involved in dorsal/ventral axis specification	IDA IDA: Inferred from direct assay	9192640	GOA
involved in hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	19778523	GOA
involved in hematopoietic stem cell differentiation	IDA IDA: Inferred from direct assay	19778523	GOA
involved in negative regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	18941195	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10660608	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16532032	GOA
involved in negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	10660608	GOA
involved in negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	9192640	GOA
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	19277043	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11932307	GOA
involved in negative regulation of bone remodeling	IMP IMP: Inferred from mutant phenotype	19072540	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	9391078	GOA
involved in negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17462603	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	9724099	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	19569235	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	10980594	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10347172	GOA
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	19095296	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	19095296	GOA
involved in negative regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	14581477	GOA
involved in negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	19734317	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	10980594	GOA
involved in negative regulation of insulin secretion	IDA IDA: Inferred from direct assay	17994217	GOA
involved in negative regulation of ossification	IDA IDA: Inferred from direct assay	15677765	GOA
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	19254787	GOA
involved in negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	19072540	GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10980594	GOA
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	16149051	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10660608	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19723665	GOA
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	10660608	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9391078	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9724099	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18941195	GOA
involved in positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	24080158	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	10980594	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10980594	GOA
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16288033	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	9391078	GOA
acts upstream of or within positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	12055200	GOA
involved in positive regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	15886250	GOA
involved in positive regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	14581477	GOA
involved in positive regulation of non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19569235	GOA
involved in positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	17035233	GOA
acts upstream of or within positive effect positive regulation of type B pancreatic cell proliferation	IDA IDA: Inferred from direct assay	17994217	GOA
involved in regulation of cell cycle process	IMP IMP: Inferred from mutant phenotype	9724099	GOA
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	20208569	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	9192640	GOA
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	9192640	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14581477	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	9192640	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFRP1 Protein Structure

NTR

0
100
200
300
314 a.a.

Protein Preferred Names	Protein Names
secreted frizzled-related protein 1	SARP-2 frizzled-related protein sFRP-1 secreted apoptosis-related protein 2

SFRP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SFRP1	Q8N474	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	SFRP1	Q8N474	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	SFRP1	Q8N474	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	SFRP1	Q8N474	FZD6	Homo sapiens	O60353	Anti Tag CoIP	10347172

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SFRP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74554	SFRP1 Protein, Human (HEK293, His)	Q8N474 (S32-K314)	≥ 95%, as determined by reducing SDS-PAGE.

SFRP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83566	SFRP1 Antibody (YA3311)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Acute Closed-Angle Glaucoma	Acute Angle-Closure Glaucoma
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Chronic Closed-Angle Glaucoma	Anatomical Narrow Angle Glaucoma Chronic Angle-Closure Glaucoma Chronic Narrow Angle Glaucoma Secondary Angle-Closure Glaucoma - Synechial
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10858	WAY 316606		99.24%	Unkown
HY-117738	Benarthin	Inhibitor	95.79%	Unkown
HY-10860	WAY-362692		99.91%	Unkown
HY-10858A	WAY 316606 hydrochloride		98.04%	Unkown
HY-202887	BCN512	Inhibitor	99.77%	Unkown
HY-RS12772	SFRP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12773	Sfrp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12774	Sfrp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180876	SFRP1 modulator-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SFRP1	VGNC	VGNC:34520
Felis catus	SFRP1	VGNC	VGNC:80004
Mus musculus	SFRP1	MGD	MGI:892014
Rattus norvegicus	SFRP1	RGD	RGD:621074
Canis familiaris	SFRP1	VGNC	VGNC:46080
Macaca mulatta	SFRP1	VGNC	VGNC:77185
Others	SFRP1	NCBI