Xpo1 - exportin 1 Gene

Also Known as exp1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85252

Summary

Enables protein domain specific binding activity. Involved in negative regulation of transcription by RNA polymerase II; protein export from nucleus; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including annulate lamellae; kinetochore; and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Apr 2022]

Xpo1 Products (1)

mRNA Protein Name
NM_053490.2 NP_445942.1 exportin-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
27013579 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10438867 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11689633 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to salt IEP
IEP: Inferred from expression pattern
27013579 RGD
involved in cellular response to triglyceride IEP
IEP: Inferred from expression pattern
27013579 RGD
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11689633 RGD
involved in protein export from nucleus IDA
IDA: Inferred from direct assay
11689633 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11689633 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

exportin-1

  • chromosome region maintenance 1 protein homolog

  • exportin 1 (CRM1, yeast, homolog)

  • exportin 1, CRM1 homolog

Xpo1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Xpo1 Q80U96 NS2 Murine minute virus P0DJZ2
Anti Bait CoIP
10438867
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-100423 Eltanexor Inhibitor 99.84% Phase 2
HY-15970 Verdinexor 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111485 Ertabresib 98.34% Unkown
HY-170669 PROTAC XPO1 degrader-1 99.77% Unkown
HY-164710 Biotinylated leptomycin B 99.32% Unkown
HY-144763 XPO1-IN-1 Inducer 98.08% Unkown
HY-W010525 Piperidin-4-ylmethanamine 99.94% Unkown
HY-RS15889 XPO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113902 (2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride Inhibitor / Unkown
HY-161391 CW0134 Modulator / Unkown
HY-161392 CW2158 Modulator / Unkown
HY-170671 E3 ligase Ligand 49 / Unkown
HY-170672 XPO1-ligand-1 Ligand / Unkown
HY-170673 E3 Ligase Ligand-linker Conjugate 156 / Unkown
HY-174132 CW8001 Inhibitor / Unkown
HY-111485R Ertabresib (Standard) / Unkown
HY-163902 SP100030 analogue 1 Inhibitor / Unkown
HY-RS16700 Xpo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23134 Xpo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xpo1 NCBI NCBI:7514