NUMB - NUMB endocytic adaptor protein Gene

Also Known as S171; C14orf41; c14_5527

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8650

About NUMB

Cytogenetic location: 14q24.2-q24.3 Genomic coordinates (GRCh38): 14:73,275,216-73,458,546 (from NCBI)

This gene has 28 transcripts (splice variants), 219 orthologues and 11 paralogues. Ubiquitous expression in lung (RPKM 25.7), gall bladder (RPKM 21.4) and 25 other tissues.

Summary

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

NUMB Products (5)

mRNA	Protein	Name
NM_001005743.2	NP_001005743.1	protein numb homolog isoform 1
NM_001005744.2	NP_001005744.1	protein numb homolog isoform 2
NM_001005745.2	NP_001005745.1	protein numb homolog isoform 4
NM_001320114.2	NP_001307043.1	protein numb homolog isoform 2
NM_003744.6	NP_003735.3	protein numb homolog isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19581412	GOA
involved in positive regulation of cell migration	IGI IGI: Inferred from genetic interaction	19581412	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19581412	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	19581412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUMB Protein Structure

PID

NumbF

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names	Protein Names
protein numb homolog	h-Numb

NUMB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUMB	P49757	REPS1	Homo sapiens	Q96D71	Pull Down	23211419
Intra	NUMB	P49757	REPS1	Homo sapiens	Q96D71	Anti Bait CoIP	23211419
Intra	NUMB	P49757	TP53	Homo sapiens	P04637	Anti Bait CoIP	18172499
Intra	NUMB	P49757	TP53	Homo sapiens	P04637	Anti Tag CoIP	18172499
Intra	NUMB	P49757	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	18172499
Intra	NUMB	P49757	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	18172499
Intra	NUMB	P49757	EPS15	Homo sapiens	P42566	Anti Bait CoIP	23211419
Intra	NUMB	P49757	EPS15	Homo sapiens	P42566	Pull Down	9303539
Intra	NUMB	P49757	EPS15	Homo sapiens	P42566	CoIP	9303539
Intra	NUMB	P49757	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	24561623

Cross: Cross-species interaction Intra: Intraspecies interaction

NUMB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80253	NUMB Antibody (YA258)	WB, ICC/IF, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Maxillary Sinus Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of Maxillary Sinus Adenoid Cystic Carcinoma Of The Maxillary Sinus
Tarp Syndrome	TARPS Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava Pierre Robin Sequence - Congenital Heart Defect - Talipes Pierre Robin Syndrome - Congenital Heart Defect - Talipes Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Tactile Agnosia
Pericoronitis	Operculitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119734	Gossypolone		96.28%	Unkown
HY-N7013	Hydroxy-Epsilon-Sanshool		/	Unkown
HY-N7014	Hydroxyl-γ-isosanshool		/	Unkown
HY-RS09681	NUMB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N12639	β-Sanshool	Activator	/	Unkown
HY-N12768	Rhodojaponin VI	Inhibitor	/	Unkown
HY-RS19926	Numb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26428	Numb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NUMB	MGD	MGI:107423
Macaca mulatta	NUMB	VGNC	VGNC:75557
Felis catus	NUMB	VGNC	VGNC:68596
Canis familiaris	NUMB	VGNC	VGNC:49933
Rattus norvegicus	NUMB	RGD	RGD:620107
Bos taurus	NUMB	VGNC	VGNC:50234
Others	NUMB	NCBI