EIF3G - eukaryotic translation initiation factor 3 subunit G Gene

Homo sapiens

Also known as EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta

Gene ID: 8666 | Gene type: protein coding

About EIF3G

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,115,014-10,119,899 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues.

Summary

This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal Caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

EIF3G Products(1)

mRNA	Protein	Name
NM_003755.5	NP_003746.2	eukaryotic translation initiation factor 3 subunit G

EIF3G Protein Structure

eIF3g

RRM_1

0
100
200
300
320 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit G

eukaryotic translation initiation factor 3 RNA-binding subunit

Recombinant EIF3G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700506	EIF3G Protein, Human (His-SUMO)	O75821 (P2-N320)	≥95%

Related Diseases

Diseases

Alias

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Cardiomyopathy, Familial Hypertrophic, 15

Hypertrophic Cardiomyopathy 15	CMH15
Cardiomyopathy, Hypertrophic, 15	Cardiomyopathy Familial Hypertrophic 15
Cardiomyopathy, Familial Hypertrophic 15	Cardiomyopathy, Hypertrophic, Familial, Type 15

Craniotubular Dysplasia, Ikegawa Type

CTDI	Craniotubular Dysplasia Ikegawa Type
Doid:0112340

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04263	EIF3G Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EIF3G	RGD	RGD:1307191
Canis familiaris	EIF3G	VGNC	VGNC:40273
Bos taurus	EIF3G	VGNC	VGNC:28397
Macaca mulatta	EIF3G	VGNC	VGNC:72190
Felis catus	EIF3G	VGNC	VGNC:61783
Mus musculus	EIF3G	MGD	MGI:1858258
Others	EIF3G	NCBI

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