EIF3G - eukaryotic translation initiation factor 3 subunit G Gene

Also Known as EIF3S4; EIF3-P42; eIF3-p44; eIF3-delta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8666

About EIF3G

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,115,014-10,119,899 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in ovary (RPKM 90.1), testis (RPKM 63.4) and 25 other tissues.

Summary

This gene encodes a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex, which is required for initiation of protein translation. An N-terminal Caspase cleavage product of the encoded protein may stimulate degradation of DNA. A mutation in this gene is associated with narcolepsy. [provided by RefSeq, Jul 2016]

EIF3G Products (1)

mRNA Protein Name
NM_003755.5 NP_003746.2 eukaryotic translation initiation factor 3 subunit G

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
25849773 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14688252 GOA
contributes to translation initiation factor activity IDA
IDA: Inferred from direct assay
17581632 GOA
Biological Process GO Annotation Evidence References Source
involved in translational initiation IDA
IDA: Inferred from direct assay
17581632 GOA
involved in viral translational termination-reinitiation IDA
IDA: Inferred from direct assay
21347434 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12426392 GOA
part of eukaryotic translation initiation factor 3 complex IDA
IDA: Inferred from direct assay
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: Inferred from physical interaction
17322308 GOA
NOT located in nucleus IDA
IDA: Inferred from direct assay
12426392 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3G Protein Structure

eIF3g

eIF3g: Eukaryotic translation initiation factor 3 subunit G (54 - 175)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (241 - 303)

  • 0
  • 100
  • 200
  • 300
  • 320 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit G

  • eukaryotic translation initiation factor 3 RNA-binding subunit

EIF3G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EIF3G O75821 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
EIF3G O75821 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
EIF3G O75821 PELO Homo sapiens Q9BRX2
Pull Down
20406461
Intra
EIF3G O75821 PELO Homo sapiens Q9BRX2
Anti Tag CoIP
20406461
Intra
EIF3G O75821 PELO Homo sapiens Q9BRX2
Y2H
20406461
Intra
EIF3G O75821 PELO Homo sapiens Q9BRX2
Anti Bait CoIP
20406461
Intra
EIF3G O75821 PELO Homo sapiens Q9BRX2
BiFC
20406461
Intra
EIF3G O75821 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
EIF3G O75821 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
EIF3G O75821 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
EIF3G O75821 EIF3I Homo sapiens Q13347
Anti Tag CoIP
33961781
Intra
EIF3G O75821 EIF3I Homo sapiens Q13347
Anti Tag CoIP
28514442
Intra
EIF3G O75821 EIF3I Homo sapiens Q13347
Anti Tag CoIP
35271311
Intra
EIF3G O75821 EIF3I Homo sapiens Q13347
Y2H Array
17094969
Intra
EIF3G O75821 EIF3I Homo sapiens Q13347
SLCA
18599441
Intra
EIF3G O75821 AIFM1 Homo sapiens O95831
Pull Down
17094969
Intra
EIF3G O75821 AIFM1 Homo sapiens O95831
Y2H Array
17094969
Intra
EIF3G O75821 EIF3B Homo sapiens P55884
Anti Tag CoIP
33961781
Intra
EIF3G O75821 EIF3B Homo sapiens P55884
Anti Tag CoIP
24396066
Intra
EIF3G O75821 EIF3B Homo sapiens P55884
Anti Tag CoIP
35271311
Intra
EIF3G O75821 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
EIF3G O75821 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
EIF3G O75821 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
EIF3G O75821 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
EIF3G O75821 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
EIF3G O75821 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
EIF3G O75821 ACD Homo sapiens Q96AP0
Pull Down
21044950
Intra
EIF3G O75821 MIF4GD Homo sapiens A9UHW6-2
Y2H Array
32296183
Intra
EIF3G O75821 MIF4GD Homo sapiens A9UHW6-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF3G Proteins

Cat. No. Product Name Accession Purity
HY-P700506 EIF3G Protein, Human (His-SUMO) O75821 (P2-N320) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Cardiomyopathy, Familial Hypertrophic, 15

  • Hypertrophic Cardiomyopathy 15

  • CMH15

  • Cardiomyopathy, Hypertrophic, 15

  • Cardiomyopathy Familial Hypertrophic 15

  • Cardiomyopathy, Familial Hypertrophic 15

  • Cardiomyopathy, Hypertrophic, Familial, Type 15
Craniotubular Dysplasia, Ikegawa Type

  • CTDI

  • Craniotubular Dysplasia Ikegawa Type

  • Doid:0112340
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04263 EIF3G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20917 Eif3g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27434 Eif3g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EIF3G RGD RGD:1307191
Canis familiaris EIF3G VGNC VGNC:40273
Bos taurus EIF3G VGNC VGNC:28397
Macaca mulatta EIF3G VGNC VGNC:72190
Felis catus EIF3G VGNC VGNC:61783
Mus musculus EIF3G MGD MGI:1858258
Others EIF3G NCBI