VPS26A - VPS26 retromer complex component A Gene

Homo sapiens

Also known as HB58; PEP8A; VPS26; Hbeta58

Gene ID: 9559 | Gene type: protein coding

About VPS26A

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,124,178-69,174,412 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 20.4), esophagus (RPKM 15.7) and 25 other tissues.

Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

VPS26A Products(5)

mRNA	Protein	Name
NM_001035260.3	NP_001030337.1	vacuolar protein sorting-associated protein 26A isoform 2
NM_001318944.2	NP_001305873.1	vacuolar protein sorting-associated protein 26A isoform 3
NM_001318945.2	NP_001305874.1	vacuolar protein sorting-associated protein 26A isoform 4
NM_001318946.2	NP_001305875.1	vacuolar protein sorting-associated protein 26A isoform 5
NM_004896.5	NP_004887.2	vacuolar protein sorting-associated protein 26A isoform 1

VPS26A Protein Structure

Vps26

0
100
200
300
327 a.a.

Protein Preferred Names

Protein Names

vacuolar protein sorting-associated protein 26A

VPS26 retromer complex comonent A

Related Diseases

Diseases

Alias

Ritscher-Schinzel Syndrome

3c Syndrome	Ccc Dysplasia
Craniocerebellocardiac Dysplasia	Cranio-Cerebello-Cardiac Dysplasia

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15679	VPS26A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VPS26A	MGD	MGI:1353654
Canis familiaris	VPS26A	VGNC	VGNC:48280
Felis catus	VPS26A	VGNC	VGNC:66960
Rattus norvegicus	VPS26A	RGD	RGD:1359254
Macaca mulatta	VPS26A	VGNC	VGNC:78775
Bos taurus	VPS26A	VGNC	VGNC:36814

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