VPS35 - VPS35 retromer complex component Gene

Also Known as MEM3; PARK17

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55737

About VPS35

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,656,132-46,689,178 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 28.7), urinary bladder (RPKM 22.9) and 25 other tissues.

Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

VPS35 Products (1)

mRNA	Protein	Name
NM_018206.6	NP_060676.2	vacuolar protein sorting-associated protein 35

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	27460146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11102511	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	20164305	GOA
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in mitochondrion to lysosome vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in negative regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in negative regulation of late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	23563491	GOA
involved in neurotransmitter receptor transport, endosome to plasma membrane	IDA IDA: Inferred from direct assay	27460146	GOA
involved in positive regulation of dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	27460146	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	26618722	GOA
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in positive regulation of protein localization to cell periphery	IMP IMP: Inferred from mutant phenotype	25533483	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	28892079	GOA
involved in regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in regulation of mitochondrion organization	IGI IGI: Inferred from genetic interaction	26618722	GOA
involved in regulation of protein metabolic process	IDA IDA: Inferred from direct assay	26618722	GOA
involved in regulation of protein metabolic process	IGI IGI: Inferred from genetic interaction	25533483	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	18193037	GOA
involved in regulation of terminal button organization	IMP IMP: Inferred from mutant phenotype	26618722	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	15078903	GOA
involved in transcytosis	IDA IDA: Inferred from direct assay	15247922	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11102511	GOA
located in early endosome	IDA IDA: Inferred from direct assay	18160348	GOA
located in endosome	IDA IDA: Inferred from direct assay	15078903	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	27385586	GOA
colocalizes with mitochondrion	IDA IDA: Inferred from direct assay	26618722	GOA
located in mitochondrion-derived vesicle	IDA IDA: Inferred from direct assay	26618722	GOA
part of retromer complex	IDA IDA: Inferred from direct assay	11102511	GOA
part of retromer, cargo-selective complex	IDA IDA: Inferred from direct assay	20164305	GOA
located in tubular endosome	IDA IDA: Inferred from direct assay	15078903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS35 Protein Structure

Vps35

0
200
400
600
796 a.a.

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 35	hVPS35

VPS35 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	TSA	24747528
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	24152121
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	17891154
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Pull Down	17891154
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Y2H	16732284
Intra	VPS35	Q96QK1	VPS26A	Homo sapiens	O75436	Anti Bait CoIP	11102511
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0-2	Validated Y2H	32296183
Intra	VPS35	Q96QK1	VPS26B	Homo sapiens	Q4G0F5	Anti Tag CoIP	35271311
Intra	VPS35	Q96QK1	VPS26B	Homo sapiens	Q4G0F5	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	TSA	24747528
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Validated Y2H	25416956
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Y2H Prey Pooling	25416956
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	35271311
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	24152121
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	Anti Tag CoIP	17891154
Intra	VPS35	Q96QK1	VPS29	Homo sapiens	Q9UBQ0	GMS	11102511
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	33961781
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	35271311
Intra	VPS35	Q96QK1	TBC1D5	Homo sapiens	Q92609	Anti Tag CoIP	37172566
Cross	VPS35	Q96QK1	Vps29	Mus musculus	Q9QZ88	ITC	24152121
Intra	VPS35	Q96QK1	WASHC2C	Homo sapiens	Q9Y4E1	Anti Tag CoIP	24980502
Intra	VPS35	Q96QK1	WASHC2C	Homo sapiens	Q9Y4E1	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Hereditary Late-Onset Parkinson Disease	Autosomal Dominant Late-Onset Parkinson Disease Lopd Hereditary Late Onset Parkinson Disease
Meier-Gorlin Syndrome 3	MGORS3 Meier-Gorlin Syndrome, Type 3
Glioma
Parkinson Disease 21	PARK21 Parkinson'S Disease 21 Parkinson Disease, Type 21
Kufor-Rakeb Syndrome	Park9 Krppd KRS Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia Autosomal Recessive Parkinson Disease 9 Parkinson Disease 9 Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset Autosomal Recessive Juvenile Onset Parkinson Disease 9 Parkinson Disease Type 9 Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia Park 9 Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis Cln12 Disease Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis Parkinson Disease Autosomal Recessive 9
Early-Onset Parkinson'S Disease	Early-Onset Parkinson Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15
Neuroaxonal Dystrophy	Neuroaxonal Dystrophies
Movement Disease	Movement Disorders Movement Disorder
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Sphingolipidosis	Sphingolipidoses
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11345	VPS35 c-terminal peptide		97.75%	Unkown
HY-RS15685	VPS35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15686	VPS35L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21083	Vps35 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27600	Vps35 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VPS35	VGNC	VGNC:36818
Felis catus	VPS35	VGNC	VGNC:66964
Canis familiaris	VPS35	VGNC	VGNC:48285
Rattus norvegicus	VPS35	RGD	RGD:1589784
Macaca mulatta	VPS35	VGNC	VGNC:78928
Mus musculus	VPS35	MGD	MGI:1890467
Others	VPS35	NCBI